Patent US3208872A successfully refreshed from Google Patents.
Patent EP0169105A2 successfully refreshed from Google Patents.
EP0169105A2
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EP
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Controlled porosity osmotic pump
Assignee: Merck and Co Inc
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Filing: 1985-06-12
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Granted: —
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Expires: 2005-06-12
Abstract
Abstract (57) The instant invention is directed to an osmotic pump comprising: (a) at least one active agent surrounded by (b) a water insoluble wall, having a fluid permeability of 6.96 x 10 -18 to 6.96 x 10 -14 cm 3 sec/g and a reflection coefficient of less than 1, prepared from: (i) a polymer permeable to water but impermeable to solute, and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.
Inventors
- 👤 Gaylen M. Zentner
- 👤 Gerald S. Rork
- 👤 Kenneth J. Himmelstein
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
82 words
An osmotic pump, comprising: (A) at least one active agent surrounded by (B) a water insoluble wall, having a fluid permeability of 6.96 x 10 -18 to 6.96 x 10 -14 cm sec/g and a reflection coefficient of less than 1, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.
Claim 2
Dependent Claim
82 words
An osmotic pump, comprising: (A) at least one active agent surrounded by (B) a water insoluble wall, having a fluid permeability of 6.96 x 10 -18 to 6.96 x 10 -14 cm sec/g and a reflection coefficient of less than 1, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.
Claim 3
Dependent Claim
60 words
The osmotic pump of Claim 1, wherein said pore forming additive comprises: (a) 0.1 to 50%, by weight, solid additive, based on the total weight of (i) and (ii), and/or (b) 0.1 to 40%, by weight, liquid additive, based on the total weight of (i) and (ii), not to exceed a total weight % of pore forming additive of 60%.
Claim 4
Dependent Claim
14 words
The osmotic pump of Claim 1, wherein said reflection coefficient is 0 to 0.08.
Claim 5
Dependent Claim
42 words
The osmotic pump of Claim 1, further comprising: (C) 0 to 50 parts per 100 parts of (i) and (ii) of plasticizer and flux regulating additives and (D) 0 to 40 parts per 100 parts of (i) and (ii), of surfactant additive.
Claim 6
Dependent Claim
36 words
The osmotic pump of Claim 1, wherein said water insolube wall is 1 to 1,000 microns thick and wherein 5 to 95% of the resulting wall pores are -between 10 angstroms and 100 microns in diameter.
Claim 7
Dependent Claim
28 words
The osmotic pump of claim 5 wherein said wall is 20 to 500 microns thick and said wall pores are between 10 angstroms and 25 microns in diameter.
Claim 8
Dependent Claim
16 words
The osmotic pump of claim 1, wherein at least 0.05 ng of active agent are used.
Claim 9
Dependent Claim
16 words
The osmotic pump of Claim 7, wherein at least 1 microgram of active agent is used.
Claim 10
Dependent Claim
37 words
The osmotic pump of Claim 1, wherein said polymer is selected from the group consisting of cellulose esters, acylated polysaccharides, polyurethane, polymers of acrylic and methacrylic acid and esters thereof, poly (ortho ester)s, polyacetals and mixtures thereof.
References Cited (Backward Citations)
No citation records indexed.
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