Patent EP0146398A2 successfully refreshed from Google Patents.
EP0146398A2
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Method of producing biodegradable prothesis and products therefrom
Assignee: Southern Research Institute
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Filing: 1984-12-18
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Granted: —
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Expires: 2004-12-18
Abstract
Abstract Method of producing biodegradable prostheses comprising a composite of resorbable fibers reinforcing a biodegradable polymer matrix and the use thereof in medical applications such as bone plates and other orthopedic devices. The fibers include ceramic powders, β-TCP and CaAI and a biodegradable glass, CMP.
Inventors
- 👤 Richard L. Dunn
- 👤 Robert A. Casper
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 09:22
CPC Classifications
C; C08; C08K; C08K7/00; C08K7/02; C08K7/04; C08K7/08; A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
41 words
A method of producing a biodegradable prosthesis, comprising the steps of a) encasing an effective amount of resorbable fibers in a matrix of a biodegradable synthetic polymer to form a composite; and b) forming said composite to the desired prosthetic shape.
Claim 2
Independent Claim
41 words
A method of producing a biodegradable prosthesis, comprising the steps of a) encasing an effective amount of resorbable fibers in a matrix of a biodegradable synthetic polymer to form a composite; and b) forming said composite to the desired prosthetic shape.
Claim 3
Dependent Claim
14 words
A method as defined in Claim 1 wherein said fibers are calcium phosphate fibers.
Claim 4
Dependent Claim
17 words
A method as defined in Claim 2 wherein said calcium phosphate fibers are comprised of 0-tricalcium phosphate.
Claim 5
Dependent Claim
17 words
A method as defined in Claim 2 wherein said calcium phosphate fibers are comprised of calcium metaphosphate.
Claim 6
Dependent Claim
13 words
A method as defined in Claim 2 wherein said fibers are CaAl fibers.
Claim 7
Dependent Claim
16 words
A method a defined in Claim 1 wherein said effective amount ranges from 10-90% by volume.
Claim 8
Dependent Claim
17 words
A method as defined in Claim 1 wherein said effective amount I is preferably 30-80% by volume.
Claim 9
Dependent Claim
19 words
A method as defined in Claim 1 wherein the aspect ratio of said fibers ranges from 10:1 to 1,000,000:1.
Claim 10
Dependent Claim
48 words
A method a defined in Claim 1 wherein said polymer is selected from the group consisting of polycaprolactone, poly(L-lactide), poly(L-lactide-co-glycolide), poly(DL-lactide), polyglycolide, 95:5 poly(DL-iactide-coglycolide), 90:10 poly(DL-lactide-co- glycolide), 85:15 poly(DL-lactide-co-glycolide), 75:25 poly(DL- lactide-co-glycolide), 50:50 poly(DL-lactide-co-glycolide), 90:10 poly(DL-lactide-co-caprolactone), 75:25 poly(DL-lactide-co- caprolactone), 50:50 poly(DL-lactide-co-caprolactone), polydioxanone, polyesteramides, copolyoxalates, polycarbonates, and poly(glutamic-co-leucine). t
Claim 11
Independent Claim
53 words
A method of producing a biodegradable fracture-fixation appliance reinforcement, comprising the steps of a) preparing resorbable calcium phosphate fibers having an aspect ratio of 10:1 to 1,000,000:1; b) incorporating from 10-90% by volume of said fibers within a nontoxic biodegradable polymer to form a composite; and c) fabricating said reinforcement from said composite.
Claim 12
Independent Claim
53 words
A method of producing a biodegradable fracture-fixation appliance reinforcement, comprising the steps of a) preparing resorbable calcium phosphate fibers having an aspect ratio of 10:1 to 1,000,000:1; b) incorporating from 10-90% by volume of said fibers within a nontoxic biodegradable polymer to form a composite; and c) fabricating said reinforcement from said composite.
Claim 13
Independent Claim
67 words
A method of producing a biodegradable prosthesis, comprising the steps of: a) preparing a film of a biodegradable, nontoxic polymer; b) incorporating an effective amount of resorbable calcium phosphate fibers into said film; c) repeating steps (a) and (b) a preselected number of times so as to form a composite having a predetermined number of layers of said film; and d) shaping said composite into said prothesis.
Claim 14
Independent Claim
67 words
A method of producing a biodegradable prosthesis, comprising the steps of: a) preparing a film of a biodegradable, nontoxic polymer; b) incorporating an effective amount of resorbable calcium phosphate fibers into said film; c) repeating steps (a) and (b) a preselected number of times so as to form a composite having a predetermined number of layers of said film; and d) shaping said composite into said prothesis.
Claim 15
Dependent Claim
36 words
A method as defined in Claim 11. wherein said preparing step includes dissolving said polymer in a suitable nontoxic solvent, spin casting the dissolved polymer to form said film, and removing said solvent from said film.
Claim 16
Dependent Claim
39 words
A method as defined in Claim 12 wherein said solvent is selected from the group consisting of p-dioxane, dimethyl sulfoxide, dichloromethane, chloroform, toluene, xylane, THF, acetone, hexafluoroisopropanol, hexafluoroacetone sesquihydrate, tetrachloroethane, n-cresol, ketones, esters, partially chlorinated hydrocarbons, water and benzene.
Claim 17
Dependent Claim
36 words
A biodegradable prosthesis, comprising a) a biodegradable polymer matrix; and b) bioabsorbable fibers incorporated within said matrix in an amount ranging from 10-90% by volume and said fibers having an aspect ratio of 10:1 to 1,000,000:1.
Claim 18
Dependent Claim
36 words
A biodegradable prosthesis, comprising a) a biodegradable polymer matrix; and b) bioabsorbable fibers incorporated within said matrix in an amount ranging from 10-90% by volume and said fibers having an aspect ratio of 10:1 to 1,000,000:1.
Claim 19
Dependent Claim
48 words
A biodegradable prosthesis as defined in Claim 14 wherein said polymer is selected from the group consisting of polycaprolactone, poly(L-lactide), poly(L-lactide-co-glycolide), poly(DL-lactide), polyglycolide, 95:5 poly(DL-lactide- co-glycolide), 90:10 poly(DL-lactide-co-glycolide), 85:15 poly(DLlactide-co-glycolide), 75:25 poly(DL-lactide-co-glycolide), 50:50 poly(DL-lactide-co- glycolide), 90:10 poly(DL- lactide-co-caprolactone), 75:25 poly(DL-lactide-co-caprolactone), 50:50 poly(DL-lactide-co-caprolactone), polydioxanone, polyesteramides, copolyoxalates, polycarbonates, and poly(glutamic-co-leucine).
Claim 20
Dependent Claim
14 words
A biodegradable prosthesis as defined in Claim 14 wherein said fibers are ceramic fibers.
Claim 21
Dependent Claim
14 words
A biodegradable prosthesis as defined in Claim 14 wherein said fibers are glass fibers.
Claim 22
Dependent Claim
17 words
A biodegradable prosthesis as defined in Claim 14 wherein said fibers are comprised of 8- tricalcium phosphate.
Claim 23
Dependent Claim
16 words
A biodegradable prosthesis as defined in Claim 14 wherein said fibers are comprised of calcium metaphosphate.
Claim 24
Dependent Claim
13 words
A biodegradable prosthesis as defined in Claim 14 wherein said fibers are CaAl.
Claim 25
Dependent Claim
33 words
A biodegradable prothesis as defined in Claim 14 wherein said matrix is a film of said polymer and said prosthesis comprises a predetermined number of alternating layers of said film and said fibers.
Claim 26
Independent Claim
34 words
A method of repairing fractured bone segments in animals, comprising the step of surgically implanting adjacent said bone segments a biodegradable prosthesis formed of a composite of resorbable fibers reinforcing a biodegradable polymer matrix.
Claim 27
Independent Claim
34 words
A method of repairing fractured bone segments in animals, comprising the step of surgically implanting adjacent said bone segments a biodegradable prosthesis formed of a composite of resorbable fibers reinforcing a biodegradable polymer matrix.
References Cited (Backward Citations)
No citation records indexed.
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