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EP0135125A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

NMR imaging utilizing chemical shift reagents

Assignee: EIDP Inc
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Filing: 1984-08-10
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Granted: —
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Expires: 2004-08-10
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Abstract

Abstract The subject invention is a process for NMR diagnostic imaging comprising introducing into a mammalian body a chemical shift reagent in an amount capable of altering the resonance frequency of atomic nuclei of diagnostic interest, and thereafter depicting the resulting shift in resonance frequency on a composite NMR signal spatial representation.

Inventors

  • 👤 Eric Thor Fossel

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 15:19
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; G01R33/483; G01R33/485

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 47 words
A process for NMR diagnostic imaging comprising introducing into a mammalian body a chemical shift reagent in an amount capable of altering the resonance frequency of atomic nuclei of diagnostic interest, and thereafter depicting the resulting shift in resonance frequency on a composite NMR signal spatial representation.
Claim 2
Dependent Claim 47 words
A process for NMR diagnostic imaging comprising introducing into a mammalian body a chemical shift reagent in an amount capable of altering the resonance frequency of atomic nuclei of diagnostic interest, and thereafter depicting the resulting shift in resonance frequency on a composite NMR signal spatial representation.
Claim 3
Dependent Claim 31 words
The process of claim 1 wherein the chemical shift reagent is selected from the group consisting of Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu.
Claim 4
Dependent Claim 30 words
The process of Claim 1 where in the chemical shift reagent is selected from the group consisting of Pr, Nd, Pm, Sm, Tb, Dy, Ho, Er, Tm, Yb and Lu.
Claim 5
Dependent Claim 23 words
The process of Claim 1 wherein the chemical shift reagent is selected from the group consisting of Tb, Tm, Pr, Yb and Lu.
Claim 6
Dependent Claim 18 words
The process of Claims 1,2,3 or 4 wherein the chemical shift reagent is in an inorganic salt form.
Claim 7
Dependent Claim 21 words
The process of Claim 1,2,3 or 4 wherein the chemical shift reagent is in a form complexed with a metal chelator.
Claim 8
Dependent Claim 23 words
The process of claim 6 wherein the metal chelator is selected from the group consisting of NTA, EDTA, HETDA, DTPA and N-hydroxyethylimino-diacetic acid.
Claim 9
Dependent Claim 21 words
The process of Claim 1,2,3 or 4 wherein the chemical shift reagent is complexed to a target seeking biologically active molecule.
Claim 10
Dependent Claim 18 words
The process of Claim 8 wherein the target seeking biologically active molecule is an antibody or antibody fragment.

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