Patent EP0109653A2 successfully refreshed from Google Patents.
EP0109653A2
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EP
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Process for preparing urokinase complex
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1983-11-15
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Granted: —
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Expires: 2003-11-15
Abstract
Abstract This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ℓ, m and n are each 0 or 1 provided that ℓ, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.
Inventors
- 👤 Wasei Miyazaki
- 👤 Tsuneo Sato
- 👤 Yasuo Nakayama
- 👤 Tadao Sato
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:16
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/44; C07D207/444; C07D207/448; C07D207/452; C07D207/46; C12; C12N; C12N11/00; C12N11/02; C12N11/06; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6456; C12N9/6462; C12Y; C12Y304/00; C12Y304/21; C12Y304/21073; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
79 words
A process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented - by the formula wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ℓ, m and n are each 0 or 1 provided that 1, m and n are not 0 at the same time.
Claim 2
Dependent Claim
79 words
A process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented - by the formula wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ℓ, m and n are each 0 or 1 provided that 1, m and n are not 0 at the same time.
Claim 3
Dependent Claim
34 words
A process as defined in claim 1 wherein the protein coupling reagent is a compound of the formula wherein A and B each represent lower alkylene, ℓ and m each are 0 or 1.
Claim 4
Dependent Claim
18 words
A process as defined in claim 1 wherein the protein adsorbable by fibrin is a plasmin heavy chain.
Claim 5
Dependent Claim
17 words
A process as defined in claim 1 wherein urokinase is low molecular weight-urokinase or high molecular weight-urokinase.
Claim 6
Dependent Claim
20 words
A process as defined in claims 1 or 2 wherein A represents alkylene groups having 1 to 6 carbon atoms.
Claim 7
Dependent Claim
44 words
A process as defined in claim 1 wherein B represents alkylene groups having 1 to 6 carbon atoms which may optionally be substituted with alkylthio having 1 to 6 carbon atoms or with phenyl-alkylthio wherein the alkyl moiety has 1 to 6 carbon atoms.
Claim 8
Dependent Claim
13 words
A fibrin-adsorbable protein-urokinase complex prepared by a process as defined in claim 1.
Claim 9
Dependent Claim
25 words
A pharmaceutical composition containing the fibrin-adsorbable protein-urokinase complex prepared by a process as defined in claim 1 in combination with a pharmaceutically acceptable, non-toxic carrier.
References Cited (Backward Citations)
No citation records indexed.
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