Patent EP0080716A2 successfully refreshed from Google Patents.
EP0080716A2
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EP
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Perfluoro compound and emulsion thereof
Assignee: Tanabe Pharma Corp
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Filing: 1982-11-26
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Granted: —
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Expires: 2002-11-26
Abstract
Abstract A novel compound of the formula, wherein R denotes a lower perfluoroalkyl group, ℓ is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.
Inventors
- 👤 Kazumasa Yokoyama
- 👤 Chikara Riverside-Shirokita Mansion Fukaya
- 👤 Yoshio Tsuda
- 👤 Taizo Ono
- 👤 Yoshio Arakawa
- 👤 Tadakazu Suyama
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/44; C07D209/52; C07D215/00; C07D215/02; C07D215/16; C07D215/18; C07D217/00; C07D217/22; C07D221/00; C07D221/02; C07D221/04; C25; C25B; C25B3/00; C25B3/01; C25B3/05; C25B3/09; C25B3/11; C25B3/20; C25B3/27; C25B3/28
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
54 words
A perfluoro compound represented by the formula, wherein R denotes a lower perfluoroalkyl group, ℓ is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group.
Claim 2
Dependent Claim
54 words
A perfluoro compound represented by the formula, wherein R denotes a lower perfluoroalkyl group, ℓ is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group.
Claim 3
Dependent Claim
31 words
The perfluoro compound of Claim 1, wherein the condensed ring skeleton A+B is perhydro-quinoline, -isoquinoline, -indole, -isoindole, -cyclopenta[b]-pyrrole, -pyridine or -isopyri d i ne , all of which has been perfluorinated.
Claim 4
Dependent Claim
82 words
A process for producing a perfluoro compound represented by the formula, wherein R denotes a lower perfluoroalkyl group, i is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, comprising reacting a perhydro compound of the formula, wherein R, ℓ, m, n and rings A and B are same as above, with fluorine.
Claim 5
Dependent Claim
82 words
A process for producing a perfluoro compound represented by the formula, wherein R denotes a lower perfluoroalkyl group, i is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, comprising reacting a perhydro compound of the formula, wherein R, ℓ, m, n and rings A and B are same as above, with fluorine.
Claim 6
Dependent Claim
22 words
The process according to Claim 3, wherein the reaction is carried out with fluorine in nascent state in electrolysis of hydrogen fluoride.
Claim 7
Dependent Claim
46 words
A stable emulsion in a physiologically acceptable aqueous medium of a perfluoro compound capable of carrying oxygen, having a particle size of less than 0.3 u, which comprises at least one compound having 8-12 carbon atoms defined in Claim 1, an emulsifying agent and an adjuvant.
Claim 8
Dependent Claim
31 words
The stable emulsion of Claim 5, wherein the emulsifying agent is a high molecular weight nonionic surfactant having a molecular weight of 2,000 to 20,000, and the adjuvant is a phospholipid.
Claim 9
Dependent Claim
28 words
The stable emulsion of Claim 6, wherein the adjuvant is, in addition, at least one fatty acid having 8 to 22 carbon atoms or physiologically acceptable salt thereof.
Claim 10
Dependent Claim
21 words
The stable emulsion of Claim 5, wherein the emulsion contains at least one plasma expander selected from hydroxyethyl starch and dextran.
Claim 11
Dependent Claim
19 words
The stable emulsion of Claim 5, 6, 7 or 8, wherein the perfluoro compound is perfluoro-N-methyldecahydroquinoline or perfluoro-N-methyldecahydro- isoquinoline.
Claim 12
Dependent Claim
28 words
The use of the perfluoro compound in Claim 1 in the form of an aqueous emulsion as blood substitute and as perfusion fluid for preservation of internal organs.
References Cited (Backward Citations)
No citation records indexed.
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