Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
74 words
A process of purifying a composition labeled with technetium-99m and containing unbound reduced technetium and/or pertechnetate impurities, which process is characterised by contacting the labeled composition with a solid particulate substrate capable of binding a technetate ion and also capable of retaining unbound reduced technetium impurity, the substrate being furnished with stannous phthalate precipitated from a saturated solution and a secondary antioxidant, and following contact with the substrate the purified labeled composition is recovered.
Claim 2
Dependent Claim
74 words
A process of purifying a composition labeled with technetium-99m and containing unbound reduced technetium and/or pertechnetate impurities, which process is characterised by contacting the labeled composition with a solid particulate substrate capable of binding a technetate ion and also capable of retaining unbound reduced technetium impurity, the substrate being furnished with stannous phthalate precipitated from a saturated solution and a secondary antioxidant, and following contact with the substrate the purified labeled composition is recovered.
Claim 3
Dependent Claim
16 words
The process according to claim 1, characterised in that the secondary antioxidant present is gentisic acid.
Claim 4
Dependent Claim
16 words
The process according to claim 1, characterised in that the secondary antioxidant present is ascorbic acid.
Claim 5
Dependent Claim
16 words
The process according to claim 1, characterised in that the particulate substrate used is cross-linked dextran.
Claim 6
Dependent Claim
20 words
The process according to any of claims 1 to 4, used to purify a composition comprising 99m TC-labeled methylene diphosphonate.
Claim 7
Dependent Claim
20 words
The process according to any of claims 1 to 4, used to purify a composition comprising 99m Tc-labeled diethylenediaminepentaacetic acid.
Claim 8
Dependent Claim
25 words
The process according to any of claims 1 to 4, used to purify a composition comprising a 99m Tc - lab e l ed protein.
Claim 9
Dependent Claim
51 words
Apparatus for purifying a composition labeled with technetium-99m, which comprises a closed container having an inert non-oxidizing atmosphere and containing a solid particulate substrate capable of binding technetate ion and capable of retaining unbound reduced technetium impurity, the substrate containing stannous phthalate precipitated from a saturated solution and a secondary antioxidant.
Claim 10
Dependent Claim
51 words
Apparatus for purifying a composition labeled with technetium-99m, which comprises a closed container having an inert non-oxidizing atmosphere and containing a solid particulate substrate capable of binding technetate ion and capable of retaining unbound reduced technetium impurity, the substrate containing stannous phthalate precipitated from a saturated solution and a secondary antioxidant.
Claim 11
Dependent Claim
15 words
The apparatus according to claim 8, characterised in that the secondary antioxidant is gentistic acid.
Claim 12
Dependent Claim
15 words
The apparatus according to claim 8, characterised in that the secondary antioxidant is ascorbic acid.
Claim 13
Independent Claim
19 words
The apparatus according to any one of claims 8, 9 and 10, wherein the particulate substrate is cross-linked dextran.
Claim 14
Dependent Claim
46 words
The process according to any of claims 1 to 7, or the apparatus according to any of claims 8 to 11, characterised in that the stannous ion concentration in the substrate is from 2 x 10 -3 to 0.1 x 10 -3 milli- equivalents per millilitre.