Patent EP0006544B1 successfully refreshed from Google Patents.
EP0006544B1
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EP
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Implantable material for bone replacement based on calcium phosphate ceramics in a matrix and method of preparing same
Assignee: Battelle-Institut
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Filing: 1979-06-15
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Granted: 1981-11-04
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Expires: 1999-06-15
Abstract
Abstract An implantable bone replacement material (body) based on completely or partially resorbable particles incorporated in a matrix material. The particles are composed of bioactive sintered calcium phosphate ceramic material having a CaO:P2O5 composition ratio between 3:1 and 4:1. The replacement material (body) consists of a metal containing calcium phosphate ceramic material in the form of a monolayer of particles in the peripheral areas of the material (body) which serve as interfaces to the body tissue. The metal is compatible with body tissue. The ceramic particles have a size range between about 500 mu m and a few millimeters. The calcium phosphate particles are located so that they lie exposed on the upper surface of the material (body). Other embodiments and processes are also disclosed.
Inventors
- 👤 Helmut Dr. Heide
- 👤 Eva Dr. Poeschel
- 👤 Ulrich Roth
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 15:43
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61C; A61C8/00; A61C8/0012; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/28; A61L27/30; A61L27/32; A61L27/40; A61L27/42; A61L27/427; C; C08; C08K; C08K3/00; C08K3/02; C08K3/08; C08K3/32; A61C8/0013; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30032; A61F2002/3006; A61F2002/30062; A61F2/30767; A61F2002/30929; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0014; A61F2250/003; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00023; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61L2430/00; A61L2430/02; Y; Y10; Y10T; Y10T428/00; Y10T428/12; Y10T428/12014; Y10T428/12021
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
125 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4 : 1, characterized in that the material consists of a solid core of a metal (1, 1') compatible with body tissue containing calcium phosphate ceramic material in the form of a monolayer of particles in its peripheral areas which serve as interfaces to the body tissue, the particles (2) having a size range between about 500 um and a few millimeters, and the calcium phosphate particles (2) being located so that they are exposed on the outer surface of the material.
Claim 2
Dependent Claim
125 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4 : 1, characterized in that the material consists of a solid core of a metal (1, 1') compatible with body tissue containing calcium phosphate ceramic material in the form of a monolayer of particles in its peripheral areas which serve as interfaces to the body tissue, the particles (2) having a size range between about 500 um and a few millimeters, and the calcium phosphate particles (2) being located so that they are exposed on the outer surface of the material.
Claim 3
Dependent Claim
40 words
A bone replacement material as claimed in Claim 1 wherein additional calcium phosphate ceramic material (3) in fine-grained form i. e. with a particle size range between about 20 and 100 µm, is incorporated in the peripheral areas (Figure 4).
Claim 4
Dependent Claim
62 words
A bone replacement material as claimed in Claim 1 wherein additional fine-grained calcium phosphate ceramic material (3), with a particle size range between about 20 and 100 gm, is present in approximately uniform distribution throughout the whole matrix metal (1) and wherein the volume of fine-grained calcium phosphate ceramic (3) in the metal (1) is between 10 and 30 percent (Figure 2).
Claim 5
Dependent Claim
107 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4 : 1, characterized in that the calcium phosphate ceramic is incorporated in a matrix which is made form metal (1) compatible with body tissue, the ceramic being in the form of uniformly distributed particles (3) in a size range between 20 and 100 gm, and the volume of the calcium phosphate ceramic in the metal being between 10 and 30 percent (Figure 3).
Claim 6
Dependent Claim
107 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4 : 1, characterized in that the calcium phosphate ceramic is incorporated in a matrix which is made form metal (1) compatible with body tissue, the ceramic being in the form of uniformly distributed particles (3) in a size range between 20 and 100 gm, and the volume of the calcium phosphate ceramic in the metal being between 10 and 30 percent (Figure 3).
Claim 7
Dependent Claim
108 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4: 1, characterized in that the material consists of a solid core (1') of a metal compatible with body tissue, and having a coating (6-9) of the metal with fine-grained inclusions of calcium phosphate ceramic material, the coating having been applied to the core by spraying, and the coating (6-9) containing between 10 and 40 volume percent of the calcium phosphate ceramic material (Figure 5).
Claim 8
Dependent Claim
108 words
An implantable bone replacement material based on completely or partially resorbable particles incorporated in a matrix material, the particles being made of bioactive sintered calcium phosphate ceramic material having a CaO : P 2 0 5 composition ratio between 3 : 1 and 4: 1, characterized in that the material consists of a solid core (1') of a metal compatible with body tissue, and having a coating (6-9) of the metal with fine-grained inclusions of calcium phosphate ceramic material, the coating having been applied to the core by spraying, and the coating (6-9) containing between 10 and 40 volume percent of the calcium phosphate ceramic material (Figure 5).
Claim 9
Dependent Claim
55 words
Bone replacement material as claimed in Claim 5 wherein the coating (6-9) has a multilayer structure and wherein the volume of the calcium phosphate ceramicmaterial in the metal of the individual layers of the coating rises from zero percent in the first layer (6) to between 30 and 40 percent in the outermost layer (9).
Claim 10
Dependent Claim
40 words
A process for the production of the bone replacement material of Claim 1, comprising affixing or pasting spherical calcium phosphate particles (2') to the inner wall of a mold (4), pouring or casting the matrix metal (1) into the mold.
Claim 11
Dependent Claim
24 words
Process as claimed in Claim 7 wherein melting of the calcium phosphate particles (2') is prevented by rapid cooling of the mold during casting.
Claim 12
Dependent Claim
44 words
Process as claimed in Claim 7 or 8 wherein the material is mechanically worked after its removal from the mold (4) in order to expose the calcium phosphate particles (2') at the periphery, the calcium phosphate particles serving as interfaces to the body tissue.
Claim 13
Dependent Claim
46 words
Process for the production of the bone replacement material of Claim 1 comprising affixing or pasting the calcium phosphate particles (2') to the inner wall of a mold (5), adding the matrix metal (1) in powder form and compacting by hot pressing or hot isostatic pressing.
Claim 14
Dependent Claim
26 words
Process as claimed in Claim 10 wherein between 10 and 30 volume percent of fine-grained calcium phosphate ceramic material is mixed with the matrix metal powder.
Claim 15
Dependent Claim
60 words
Process for the production of the bone replacement material of Claim 1 comprising affixing or pasting the calcium phosphate particles (2') to a core made of matrix metal, and placing it in a viscoelastic mold (5) together with matrix metal powder which fills the empty spaces, then precompacting and finally sintering the materials, or directly sintering by hot isostatir pressing.
Claim 16
Dependent Claim
33 words
Process for the production of the bone replacement material according to Claim 4, comprising compacting a finely dispersed mixture of metal powder and fine-grained calcium phosphate by hot pressing or hot isostatic pressing.
Claim 17
Dependent Claim
43 words
Process for the production of the bone replacement material according to Claim 5 or 6, comprising applying the coating, which consists of calcium phosphate ceramic material and metal that is compatible with body tissue, one layer after another by flame or plasma spraying.
References Cited (Backward Citations)
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