Patent CA1239092A successfully refreshed from Google Patents.
CA1239092A
Expired / Lapsed
CA
⏱️ 0.0 years remaining
Ultrasound contrast agents containing microparticles and gas micro-bubbles
Assignee: Bayer Pharma AG
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Filing: 1984-04-11
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Granted: 1988-07-12
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Expires: 2004-04-11
Abstract
Abstract ABSTRACT An ultrasound contrast agent containing micro-particles and gaseous micro-bubbles is described which contains microparticles of a solid surface-active substance, and optionally microparticles of a solid non-surface-active substance, in a liquid carrier. In the case of ultrasound images, after intra-venous administration it permits the contrasting of the left-hand side of the heart, the myocardium and other organs, such as the liver, the spleen, the kidneys and the right-hand side of the heart.
Inventors
- 👤 Jurgen Hilmann
- 👤 Lothar Lange
- 👤 Ingfried Zimmermann
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-10-23 17:17
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223; A61B; A61B90/00; A61B90/39; A61B2090/3925
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
32 words
A contrast agent for use in the ultrasound diagno-sis of the human or animal body, which comprises microparticles of a solid surface-active substance and micro-bubbles of a gas in a liquid carrier.
Claim 2
Dependent Claim
32 words
A contrast agent for use in the ultrasound diagno-sis of the human or animal body, which comprises microparticles of a solid surface-active substance and micro-bubbles of a gas in a liquid carrier.
Claim 3
Dependent Claim
20 words
A contrast agent as claimed in claim 1, wherein the liquid carrier also contains microparticles of a solid non-sur-face-active substance.
Claim 4
Dependent Claim
73 words
A contrast agent as claimed in claim 1, wherein the solid surface-active substance is a lecithin, a polyoxyethylene fatty acid ester, gylcerine polyethylene glycol ricinoieate, cholesterol, a polyoxyethylenepolyoxypropylene polymer, a saccha-rose ester, a xyloglyceride, a saturated or unsaturated (C4-C20)-fatty alcohol, a saturated or unsaturated (C4-C20)-fatty acid or a metal salt thereof, a mono- or di- or tri-glyceride or a fatty acid ester, or a mixture of any two or more of such substances.
Claim 5
Dependent Claim
37 words
A contrast agent as claimed in claim 3, wherein the solid surface active substance is magnesium stearate, ascorbyl palmitate, saccharose monopalmitate, saccharose monostearate or saccharose distearate, or a mixture of any two or more of such substances.
Claim 6
Dependent Claim
42 words
A contrast agent as claimed in claim 2, wherein the solid non-surface active substance is a cyclodextrine, a mono-saccharide, a disaccharide, a trisaccharide, a polyol or an inor-ganic or organic salt, or a mixture of any two or more of such substances.
Claim 7
Dependent Claim
29 words
A contrast agent as claimed in claim 2, wherein the solid non-surface-active substance is galactose, lactose or ? -cyclodextrine, or a mixture of two or more of such substances.
Claim 8
Dependent Claim
28 words
A contrast agent as claimed in claim 1, wherein the microparticles of the solid surface-active substance are present in a quantity of from 0.01 to 10% by weight.
Claim 9
Dependent Claim
28 words
A contrast agent as claimed in claim 7, wherein the microparticles of the solid surface-active substance are present in a quantity of from 0.01 to 5% by weight.
Claim 10
Dependent Claim
28 words
A contrast agent as claimed in claim 8, wherein the microparticles of the solid surface-active substance are present in a quantity of from 0.04 to 1% by weight.
Claim 11
Dependent Claim
28 words
A contrast agent as claimed in claim 2, wherein the microparticles of the solid non-surface-active substance are pre-sent in a quantity of from 5 to 50% by weight.
Claim 12
Dependent Claim
28 words
A contrast agent as claimed in claim 10, wherein the microparticles of the solid non-surface-active substance are present in a quantity of from 9 to 40% by weight.
Claim 13
Dependent Claim
35 words
A contrast agent as claimed in claim 2, 3 or 4, wherein the ratio by weight of the microparticles of the surface-active substance to the microparticles of the non-surface-active substance is from 0.01 to 5:100.
Claim 14
Dependent Claim
36 words
A contrast agent as claimed in claim 1, wherein the liquid carrier is water, a physiological electrolyte solution, an aqueous solution of a monohydric or polyhydric alcohol, or an aqueous solution of a mono- or di-saccharide.
Claim 15
Dependent Claim
23 words
A contrast agent as claimed in claim 13, wherein the liquid carrier is an aqueous solution of glycerine, polyethy-lene glycol or propylene glycol.
Claim 16
Dependent Claim
26 words
A contrast agent as claimed in claim 13, wherein the liquid carrier is physiological sodium chloride solution, 10% aqueous lactose solution or 20% aqueous galactose solution.
Claim 17
Dependent Claim
23 words
A contrast agent as claimed in claim 1, 3 or 4, which comprises microparticles of magnesium stearate in a 20% aqueous galactose solution.
Claim 18
Dependent Claim
21 words
A contrast agent as claimed in claim 2, 3 or 4, which comprises microparticles of ascorbyl palmitate and galac-tose in water.
Claim 19
Dependent Claim
25 words
A contrast agent as claimed in claim 2, 3 or 4, which comprises microparticles of ascorbyl palmitate and ? -cyclodextrine in physiological sodium chloride solution.
Claim 20
Dependent Claim
23 words
A contrast agent as claimed in claim 1, 3 or 4, which comprises microparticles of ascorbyl palmitate in a 10% aqueous lactose solution.
Claim 21
Dependent Claim
21 words
A contrast agent as claimed in claim 2, 3 or 4, which comprises microparticles of saccharose monopalmitate and galactose in water.
Claim 22
Dependent Claim
21 words
A contrast agent as claimed in claim 2, 3 or 4, which comprises microparticles of saccharose monosterate and galactose in water.
Claim 23
Dependent Claim
21 words
A contrast agent as claimed in claim 2, 3 or 4, which comprises microparticles of saccharose distearate and galactose in water.
Claim 24
Dependent Claim
24 words
A contrast agent as claimed in claim 1, 2 or 3, wherein the microparticles have a median particle size of from 1 to 3µm.
Claim 25
Dependent Claim
30 words
A liquid medium for use in making up the contrast agent claimed in claim 1, which comprises a suspension of microparticles of a solid surface-active substance in a liquid carrier.
Claim 26
Dependent Claim
21 words
A liquid medium as claimed in claim 24, wherein the liquid carrier also contains microparticles of a solid non-sur-face active carrier.
Claim 27
Dependent Claim
24 words
A liquid medium as claimed in claim 24, which con-tains from 0.01 to 10% by weight of the microparticles of the solid surface-active substance.
Claim 28
Dependent Claim
24 words
A liquid medium as claimed in claim 26, which con-tains from 0.01 to 5% by weight of the microparticles of the solid surface-active substance.
Claim 29
Dependent Claim
24 words
A liquid medium as claimed in claim 27, which con-tains from 0.04 to 1% by weight of the microparticles of the solid surface-active substance.
Claim 30
Dependent Claim
25 words
A liquid medium as claimed in claim 25, which con-tains from 5 to 50% by weight of the microparticles of the solid non-surface-active solid substance.
Claim 31
Dependent Claim
24 words
A liquid medium as claimed in claim 29, which con-tains from 9 to 40% by weight of the microparticles of the solid non-surface-active substance.
Claim 32
Dependent Claim
22 words
A liquid medium as claimed in claim 24, wherein the surface-active substance is a substance(s) as claimed in claim 3 or 4.
Claim 33
Dependent Claim
22 words
A liquid medium as claimed in claim 25, wherein the non-surface-active substance is a substance(s) as claimed in claim 5 or 6.
Claim 34
Dependent Claim
22 words
A liquid medium as claimed in claim 24, wherein the liquid carrier is a liquid as claimed in claim 13 or 14.
Claim 35
Dependent Claim
25 words
A liquid medium as claimed in claim 24, 25 or 26, wherein the microparticles have a median particle size of from 1 to 3 µm.
Claim 36
Dependent Claim
43 words
A diagnostic kit for use in the ultrasound diagnosis of the human or animal body, which comprises (A) a container which contains a liquid carrier, and (B) a second container which contains microparticles of a solid surface-active substance, and a solid non-surface-active substance.
Claim 37
Dependent Claim
43 words
A diagnostic kit for use in the ultrasound diagnosis of the human or animal body, which comprises (A) a container which contains a liquid carrier, and (B) a second container which contains microparticles of a solid surface-active substance, and a solid non-surface-active substance.
Claim 38
Dependent Claim
20 words
A kit as claimed in claim 35 in which the second container also contains microparticles of a solid non-surface-active substance.
Claim 39
Dependent Claim
24 words
A diagnostic kit as claimed in claim 35, wherein the containers A and B each has a volume of from 5 to 10 ml.
Claim 40
Dependent Claim
32 words
A diagnostic kit as claimed in claim 36, wherein the ratio by weight of the microparticles of the surface-active substance to the microparticles of the non-surface-active substance is from 0.01 to 5:100.
Claim 41
Dependent Claim
25 words
A diagnostic kit as claimed in claim 35, 36 or 37, wherein the surface-active substance is a substance(s) as claimed in claim 3 or 4.
Claim 42
Dependent Claim
22 words
A diagnostic kit as claimed in claim 36, wherein the non-surface-active substance is a substance(s) as claimed in claim 5 or 6.
Claim 43
Dependent Claim
22 words
A diagnostic kit as claimed in claim 35, wherein the liquid carrier is a liquid as claimed in claim 13 or 14.
Claim 44
Dependent Claim
27 words
A diagnostic kit as claimed in claim 35, 36 or 37 which also comprises an injection syringe for transfer-ring the contents of container (A) to container (B).
Claim 45
Dependent Claim
24 words
A diagnostic kit as claimed in claim 35, 36 or 37, wherein each of the containers (A) and (B) is a phial or ampoule.
Claim 46
Dependent Claim
25 words
A diagnostic kit as claimed in claim 35, 36 or 37, wherein the microparticles have a median particle size of from 1 to 3 µm.
Claim 47
Dependent Claim
28 words
A ampoule or phial for use in ultrasound diag-nosis of the human or animal body, which contains a contrast agent as claimed in claim 1, 2 or 3.
Claim 48
Dependent Claim
35 words
A process for the preparation of a contrast agent as claimed in claim 1, wherein microparticles of a solid surface-active substance are mixed with a liquid carrier and agitated until a homogeneous suspension is formed.
Claim 49
Dependent Claim
22 words
A process as claimed in claim 46 in which microparticles of a solid non-surface-active substance are also mixed with the liquid carrier.
References Cited (Backward Citations)
No citation records indexed.
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