Patent WO1993006791A1 successfully refreshed from Google Patents.
WO1995033062A2
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WO
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Method for introducing foreign matter into higher eukaryotic cells
Assignee: Boehringer Ingelheim International GmbH
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Filing: 1995-05-26
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Granted: —
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Expires: 2015-05-26
Abstract
Abstract The toxicity problems arising when foreign matter is introduced into higher eukaryotic cells, especially with transfection with DNA, are obviated by expression in the cell of gene products that block the apoptosis induced by the transfection process and/or by treating the cells with anti-inflammatory substances. Preferred anti-apoptosis genes are Bcl-2, E1B 19K or an anti-apoptotic gene of the CELO avian adenovirus; used as preferred anti-inflammatory substance in the adenovirus VA1, which is introduced into the cell in the form of VA1 DNA. These measures help to achieve a long-lasting gene expression.
Inventors
- 👤 Matthew Cotten
- 👤 Adam Baker
- 👤 Susanna Chiocca
Bibliographic Details
Application Number
—
Jurisdiction
WO
Data Source
google_patents
Last Synchronized
2026-10-22 23:20
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61P; A61P43/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4702; C07K14/4747; C07K14/52; C07K14/54; C07K14/5412; C07K14/5421; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/87; C12N2710/00; C12N2710/00011; C12N2710/10011; C12N2710/10211; C12N2710/10222; C12N2710/10311; C12N2710/10322
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