Cyclic ketal derivatives

Abstract

Abstract Compounds are described of formula (Ia), (Ib), wherein R1 represents a hydrogen atom, a hydroxyl group or a group selected from -OCOCH=CHCH(CH¿3?)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3 [where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)-, -CH=CHC(OH)(CH3)-, -CH2CH(OH)CH2- or -CH2CH2CH(CH3)-]; R?2¿ represents a hydroxyl group, a group -OCOR7 or a group -OCO¿2R?7 (where R7 is a group selected from C¿1-8?alkyl, aryl, arylC1-4alkyl and C3-8cycloalkyl); R?3¿ represents a group selected from (a) (where R8 is a hydrogen atom or an acetyl group), -C(CH¿3?)=CHCH(CH2R?9)CH¿2Ph (where R9 is a hydrogen or a hydroxyl group), -C(CH¿2?OH)=CHCH(CH3)CH2Ph, -C(=CH2)CH(OH)CH(CH2OH)CH2Ph, -C(=CH2)CH(NHCOCH3)CH(CH3)CH2Ph, -C(CH2NHCOCH3)=CHCH(CH3)CH2Ph and (b); R?4, R5 and R6¿ may each independently represent a hydrogen atom or a methyl group; and salts thereof. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.

Inventors

• 👤 Philip James Sidebottom
• 👤 Michael George Lester
• 👤 Panayiotis Alexandrou Procopiou
• 👤 Nigel Stephen Watson
• 👤 Stefano Biondi
• 👤 Michael Vincent John Ramsay
• 👤 David George Hubert Livermore
• 👤 Barry Clive Ross

Bibliographic Details