Abstract Novel aromatic carboxylic amides of the general formula: ##STR1## wherein each of R 1 and R 2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R 3 and R 4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3 with the proviso that when .[.Xs.]. .Iadd.X's .Iaddend.are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof. These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, .[.anticaria.]. .Iadd.urticaria .Iaddend.and atopic dermatitis. The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##STR2## where R 1 , R 2 , R 3 , R 4 , X and n have the same meanings given above, with an aminobenzoic acid of the formula: ##STR3## and, if desired, converting the resulting amide into the corresponding salts.
into an alkylene group..]. .[.2. A compound of claim 1 selected from the group consisting of a nucleus-substituted cinnamic amide of the general formula:.]. ##STR13## .[.wherein R 1 , R 2 , X and n have the same meanings as given
Claim 2
Dependent Claim
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above, and therapeutically acceptable salts thereof..]. .[.3. A compound of claim 2 wherein both R 1 and R 2 are hydrogen atoms..]. .[.4. A compound of claim 2 wherein at least one of R 1 and R 2 is an alkyl group having 1-4 carbon atoms..]. .[.5. A compound of claim 1 selected from the group consisting of a nucleus-substituted phenylpropionamide of the general formula:.]. ##STR14## ps .[.wherein R 1 , R 2 , X and n have the same meanings as given
Claim 3
Dependent Claim
40 words
above, and therapeutically acceptable salts thereof..]. .[.6. A compound of claim 5 wherein both R 1 and R 2 are hydrogen atoms..]. .[.7. A compound of claim 5 wherein at least one of R 1 and R 2 is an
Claim 4
Dependent Claim
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alkyl group having 1-4 carbon atoms..]. .Iadd.8. A compound comprising N-(3',4'-dimethoxycinnamoyl)-anthranilic acid. .Iaddend. .Iadd.9. A compound comprising N-(3',4'-dimethoxy-β-methylcinnamoyl)-anthranilic acid. .Iaddend. .Iadd.10. A compound comprising N-(3'-methoxy-4'-n-propoxycinnamoyl)-anthranilic acid. .Iaddend.