US6849262B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular coating composition
Assignee: Artivion Inc
•
Filing: 2002-02-07
•
Granted: 2005-02-01
•
Expires: 2022-02-07
Abstract
Abstract This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.
Inventors
- 👤 Jeremy Ollerenshaw
- 👤 Umit Yuksel
- 👤 Kirby S. Black
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:44
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/08; A61L31/10; A61L27/00; A61L27/28; A61L27/34; A61L27/36; A61L27/3604; A61L27/3625; A61L27/3683; A61L31/005; A61P; A61P9/00; A61P9/14; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
95 words
A method of inhibiting restenosis following vascular intervention comprising applying to a site of vascular injury resulting from said intervention a first composition comprising about 27-53% by weight of a water soluble globular protein and a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said globular protein, and allowing said composition to cure so that a coating is produced at said site of vascular injury that inhibits restenosis.
Claim 2
Independent Claim
95 words
A method of inhibiting restenosis following vascular intervention comprising applying to a site of vascular injury resulting from said intervention a first composition comprising about 27-53% by weight of a water soluble globular protein and a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said globular protein, and allowing said composition to cure so that a coating is produced at said site of vascular injury that inhibits restenosis.
Claim 3
Dependent Claim
11 words
The method according to claim 1 wherein said intervention is angioplasty.
Claim 4
Dependent Claim
14 words
The method according to claim 1 wherein said globular protein is albumin or hemoglobulin.
Claim 5
Dependent Claim
13 words
The method according to claim 3 wherein said globular protein is bovine albumin.
Claim 6
Dependent Claim
11 words
The method according to claim 1 wherein said aldehyde is glutaraldehyde.
Claim 7
Dependent Claim
18 words
The method according to claim 1 wherein said globular protein is bovine albumin and said aldehyde is glutaraldehyde.
Claim 8
Dependent Claim
14 words
The method according to claim 1 wherein said coating further comprising a therapeutic agent.
Claim 9
Dependent Claim
33 words
The method according to claim 7 wherein said therapeutic agent is selected from the group consisting of an anti-thrombotic agent, a thrombolytic agent, a vasodilating agent, a growth modulating factor and an antibiotic.
Claim 10
Independent Claim
96 words
A method of providing structural support to a surface of a hollow or tubular organ comprising: i) coating said surface with a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said structural support is provided.
Claim 11
Independent Claim
96 words
A method of providing structural support to a surface of a hollow or tubular organ comprising: i) coating said surface with a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said structural support is provided.
Claim 12
Dependent Claim
13 words
The method according to claim 9 wherein said proteinaceous material a globular protein.
Claim 13
Dependent Claim
14 words
The method according to claim 9 wherein said proteinaceous material is albumin or hemoglobin.
Claim 14
Dependent Claim
11 words
The method according to claim 9 wherein said aldehyde is glutaraldehyde.
Claim 15
Dependent Claim
18 words
The method according to claim 9 wherein said proteinaceous material is bovine albumin and said aldehyde is glutaraldehyde.
Claim 16
Dependent Claim
45 words
The method according to claim 9 wherein said surface is selected from the group consisting of the surface of a vein, artery ureter, urethrae, bronchi, biliary duct, pancreatic duct, gut, eye, nasal passage, sinus, capsular joint, esophagus, lymphatic system, trachea, spermatic tube and fallopian tube.
Claim 17
Dependent Claim
21 words
The method according to claim 9 wherein said surface is coated with said second composition and then with said first composition.
Claim 18
Independent Claim
83 words
A method of occluding a tissue lumen comprising: i) introducing into said lumen a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said lumen is occluded.
Claim 19
Independent Claim
83 words
A method of occluding a tissue lumen comprising: i) introducing into said lumen a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said lumen is occluded.
Claim 20
Dependent Claim
13 words
The method according to claim 16 wherein said proteinaceous material a globular protein.
Claim 21
Dependent Claim
14 words
The method according to claim 16 wherein said proteinaceous material is albumin or hemoglobin.
Claim 22
Dependent Claim
11 words
The method according to claim 16 wherein said aldehyde is glutaraldehyde.
Claim 23
Dependent Claim
18 words
The method according to claim 16 wherein said proteinaceous material is bovine albumin and said aldehyde is glutaraldehyde.
Claim 24
Dependent Claim
20 words
The method according to claim 16 wherein said second composition is introduced into said lumen prior to said first composition.
Claim 25
Dependent Claim
92 words
A composition comprising a support and cells adhered thereto, wherein said support is produced by a method comprising: i) contacting a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said support is thereby produced.
Claim 26
Dependent Claim
92 words
A composition comprising a support and cells adhered thereto, wherein said support is produced by a method comprising: i) contacting a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the product of step (i) to cure so that said support is thereby produced.
Claim 27
Dependent Claim
13 words
The method according to claim 22 wherein said proteinaceous material a globular protein.
Claim 28
Dependent Claim
14 words
The method according to claim 22 wherein said proteinaceous material is albumin or hemoglobin.
Claim 29
Dependent Claim
11 words
The method according to claim 22 wherein said aldehyde is glutaraldehyde.
Claim 30
Dependent Claim
18 words
The method according to claim 22 wherein said proteinaceous material is bovine albumin and said aldehyde is glutaraldehyde.
Claim 31
Independent Claim
80 words
A method of providing structural support to a surface of a hollow or tubular organ comprising: i) applying to said surface a coating comprising a water soluble proteinaceous material and a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the coating of step (i) to cure so that said structural support is provided.
Claim 32
Independent Claim
80 words
A method of providing structural support to a surface of a hollow or tubular organ comprising: i) applying to said surface a coating comprising a water soluble proteinaceous material and a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and ii) allowing the coating of step (i) to cure so that said structural support is provided.
Claim 33
Dependent Claim
13 words
The method according to claim 27 wherein said proteinaceous material a globular protein.
Claim 34
Dependent Claim
14 words
The method according to claim 27 wherein said proteinaceous material is albumin or hemoglobin.
Claim 35
Dependent Claim
11 words
The method according to claim 27 wherein said aldehyde is glutaraldehyde.
References Cited (Backward Citations)
US4247406A
Cited
US4979959A
Cited
US5213580A
Cited
US5800538A
Cited
US5830504A
Cited
US5385606A
Cited
US5914345A
Cited
US6372229B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2008-02-01 | 2008-08-02 | 2009-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2012-02-01 | 2012-08-02 | 2013-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2016-02-01 | 2016-08-02 | 2017-02-01 | $7700.00 | Window Closed / Lapsed |