US6496560B1
Expired / Lapsed
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Motion correction for perfusion measurements
Assignee: Koninklijke Philips NV
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Filing: 2001-11-21
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Granted: 2002-12-17
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Expires: 2021-11-21
Abstract
Abstract A CT scanner ( 10 ) for obtaining a medical diagnostic image of a subject includes a stationary gantry ( 12 ), and a rotating gantry ( 14 ) rotatably supported on the stationary gantry ( 12 ) for rotation about the subject. A plurality of temporally displaced volume images are gathered, divided into slices, and stored in slice memories ( 54 1 , 54 2 , . . . 54 n ). A slice comparitor ( 58 ) compares each slice to a selected reference slice. The slices are transformed by a slice transformer ( 60 ) to align the slices thereby correcting for movement of the subject over the scan period.
Inventors
- 👤 Zhongmin Steve Lin
- 👤 Shalabh Chandra
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:46
CPC Classifications
A; A61; A61B; A61B6/00; A61B6/50; A61B6/507; A61B6/02; A61B6/03; A61B6/032; A61B6/40; A61B6/4064; A61B6/4085; A61B6/52; A61B6/5258; A61B6/5264; G; G01; G01N; G01N23/00; G01N23/02; G01N23/04; G01N23/046; G06; G06T; G06T7/00; G06T7/20; G06T7/246; G06T7/30; G06T7/33; G01N2223/00; G01N2223/40; G01N2223/419; G01N2223/60; G01N2223/612; G06T2207/00; G06T2207/30; G06T2207/30004; G06T2207/30016
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
68 words
A method of compensating for motion of a subject undergoing a tissue perfusion analysis including: gathering a plurality of volume images of a region of interest over a period of time; selecting a corresponding central slice image in each volume image; determining movement in two dimensions for each central slice image relative to a reference central slice image; correcting the volume images in accordance with the determined movement.
Claim 2
Independent Claim
68 words
A method of compensating for motion of a subject undergoing a tissue perfusion analysis including: gathering a plurality of volume images of a region of interest over a period of time; selecting a corresponding central slice image in each volume image; determining movement in two dimensions for each central slice image relative to a reference central slice image; correcting the volume images in accordance with the determined movement.
Claim 3
Dependent Claim
60 words
The method as set forth in claim 1 , wherein the movement determining step further includes: generating a movement function that describes movement of the central slice image over the plurality of volume images; and the correcting step includes: correcting for movement in each volume image by applying the movement function of the corresponding slice images of the volume image.
Claim 4
Dependent Claim
39 words
The method as set forth in claim 2 , wherein the central slice images of the volume images are aligned, then other slice images of the volume images are aligned utilizing the movement function as a map of alignment.
Claim 5
Dependent Claim
42 words
The method as set forth in claim 1 , further including after selecting a central slice image: selecting a subregion of the selected central slice image and wherein the movement determining step is performed on the subregion of the corresponding slice images.
Claim 6
Dependent Claim
46 words
The method as set forth in claim 4 , wherein the step of selecting a subregion includes: selecting at least a portion of a top of a skull of the subject; and, selecting at least a portion of a side of the skull of the subject.
Claim 7
Dependent Claim
31 words
The method as set forth in claim 1 , wherein the step of selecting the subregion includes a user designating the subregion on a display of the selected central slice image.
Claim 8
Dependent Claim
34 words
The method as set forth in claim 1 , further including: transforming other slice images in each volume image with a two dimensional linear interpolation to align the other slices with the central slice.
Claim 9
Dependent Claim
53 words
The method as set forth in claim 7 , the step of selecting a subregion includes: comparing a transformed other slice image to the central slice image of the same volume image and computing a similarity measure, the similarity measure providing a quantitative measure of difference in positions of the compared slice images.
Claim 10
Dependent Claim
26 words
The method as set forth in claim 8 , further including: shifting the transformed other image if the similarity measure is outside of a preselected tolerance.
Claim 11
Dependent Claim
39 words
The method as set forth in claim 8 , wherein the similarity measure yields a measure of the similarity between a field of view of the central slice image to a field of view of the other slice image.
Claim 12
Dependent Claim
32 words
The method as set forth in claim 1 , further including: limiting motion of the region of interest of the subject to motion in two dimensions with an external subject restraint device.
Claim 13
Dependent Claim
87 words
A diagnostic imaging device for performing tissue perfusion investigations that compensates for subject motion, the device including: an imaging region for receiving a region of interest of a subject; a reconstruction processor for converting data gathered by the device into a series of volume image representations of the region of interest; a slice comparitor that compares at least portions of reference in each of the volume images with each other and relative movement of the reference slices; a transformer that aligns the reference slices with each other.
Claim 14
Dependent Claim
87 words
A diagnostic imaging device for performing tissue perfusion investigations that compensates for subject motion, the device including: an imaging region for receiving a region of interest of a subject; a reconstruction processor for converting data gathered by the device into a series of volume image representations of the region of interest; a slice comparitor that compares at least portions of reference in each of the volume images with each other and relative movement of the reference slices; a transformer that aligns the reference slices with each other.
Claim 15
Dependent Claim
38 words
The diagnostic imaging apparatus as set forth in claim 12 , wherein the slice transformer adjusts a first slice so coordinates of a subregion in the first slice match coordinates of a corresponding subregion in a second slice.
Claim 16
Dependent Claim
38 words
The diagnostic imaging device as set forth in claim 13 , wherein the image transformer adjusts subsequent, slices so coordinates of the subregion in each of the slices match the coordinates of the subregion in the first slice.
Claim 17
Dependent Claim
32 words
The diagnostic imaging device as set forth in claim 12 , further including: a function generator that generates a movement function in time that describes the relative movement of the reference slices.
Claim 18
Dependent Claim
29 words
The diagnostic imaging apparatus as set forth in claim 15 , wherein the movement function is applied to the volume images to align the volume images with each other.
Claim 19
Dependent Claim
42 words
The diagnostic imaging device as set forth in claim 12 , further including: an external restraint for restraining a region of interest of the subject against movement within the imaging region, limiting possible motion of the region of interest to two dimensions.
Claim 20
Dependent Claim
106 words
A computed tomography device for performing perfusion studies comprising: a source of penetrating radiation that produces radiation for transmission into an imaging region of the device; a detection means that detects the radiation after it traverses the imaging region; a reconstruction means that reconstructs the detected radiation into temporally displaced volume images of a region of interest of a subject in the imaging region; a means for tracking movement of a corresponding volume image subregion across the plurality of volume images; a means for determining a movement correction for each of the plurality of subregions; a means for applying the movement corrections to the volume images.
Claim 21
Dependent Claim
106 words
A computed tomography device for performing perfusion studies comprising: a source of penetrating radiation that produces radiation for transmission into an imaging region of the device; a detection means that detects the radiation after it traverses the imaging region; a reconstruction means that reconstructs the detected radiation into temporally displaced volume images of a region of interest of a subject in the imaging region; a means for tracking movement of a corresponding volume image subregion across the plurality of volume images; a means for determining a movement correction for each of the plurality of subregions; a means for applying the movement corrections to the volume images.
Claim 22
Dependent Claim
19 words
The computed tomography device as set forth in claim 18 , wherein the subregion is a single imaging slice.
Claim 23
Dependent Claim
21 words
The computed tomography device as set forth in claim 18 , wherein the subregion is a user-selected portion of a slice.
Claim 24
Dependent Claim
19 words
The computed tomography device as set forth in claim 18 , wherein the subregion is a two dimensional subsection.
References Cited (Backward Citations)
US5602891A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-12-16 | 2006-06-17 | 2006-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-12-16 | 2010-06-17 | 2010-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-12-16 | 2014-06-17 | 2014-12-17 | $7700.00 | Window Closed / Lapsed |