US6340477B1
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Bone matrix composition and methods for making and using same
Assignee: Lifenet Health
•
Filing: 2000-04-27
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Granted: 2002-01-22
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Expires: 2020-04-27
Abstract
Abstract The invention is directed to a bone matrix composition for use in the repair and healing of osseous tissue. The composition can be used in load-bearing and non-load bearing applications, including for example, orthopaedic applications including spinal applications, and oral-facial applications including dental applications. The composition includes one or more non-liquid semi-synthetic polymers; and particulate bone including allogenic, autogenic, or xenogenic bone, where the bone is cancellous, corticocancellous bone, and/or cortical bone. The composition may also optionally contain one or more pharmaceutically active agents. The composition can be formulated as a gel, putty, a paste, a cake, or solid.
Inventors
- 👤 Billy G. Anderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:57
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61K; A61K35/00; A61K35/12; A61K35/32; A61L24/00; A61L24/0005; A61L27/14; A61L27/26; A61L27/3641; A61L27/3645; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/44; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30057; A61F2002/30059; A61F2002/30667; A61F2002/30677; A61F2310/00; A61F2310/00005; A61F2310/00359; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 70
Claim 1
Independent Claim
34 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; and water.
Claim 2
Dependent Claim
34 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; and water.
Claim 3
Dependent Claim
40 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more pharmaceutically active agents.
Claim 4
Dependent Claim
40 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more pharmaceutically active agents.
Claim 5
Dependent Claim
76 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 9.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount of from about 20.0%v/v to about 90.0%v/v; and optionally containing one or more pharmaceutically active agents.
Claim 6
Dependent Claim
76 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 9.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount of from about 20.0%v/v to about 90.0%v/v; and optionally containing one or more pharmaceutically active agents.
Claim 7
Dependent Claim
16 words
A bone matrix composition, consisting essentially of: one or more non-liquid cellulosics; particulate bone; and water.
Claim 8
Dependent Claim
16 words
A bone matrix composition, consisting essentially of: one or more non-liquid cellulosics; particulate bone; and water.
Claim 9
Dependent Claim
28 words
The composition of claim 4 , wherein said one or more non-liquid cellulosics are present in an amount of from 0.1 wt % to about 9.0 wt %.
Claim 10
Dependent Claim
31 words
The composition of claim 4 , said one or more non-liquid cellulosics are selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose.
Claim 11
Dependent Claim
34 words
The composition of any one of claims 1 , 2 , 3 , or 4 , said particulate bone comprising one or members selected from the group consisting of: allogenic bone and xenogenic bone.
Claim 12
Dependent Claim
50 words
The composition of claim 7 , said particulate bone comprising one or members selected from the group consisting of: demineralized cortical bone, demineralized cancellous bone, demineralized corticocancellous bone, non-demineralized cortical bone, non-demineralized cancellous bone, non-demineralized corticocancellous bone, partially demineralized cortical bone, partially demineralized cancellous bone, and partially demineralized corticocancellous bone.
Claim 13
Dependent Claim
74 words
The composition of claim 3 , said one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, is present in an amount of from about 0.1 wt % to about 9.0 wt %; particulate bone is present in an amount of from about 35.0%v/v to about 65.0%v/v; and water is present in an amount of from about 30.0%v/v to about 70.0%v/v.
Claim 14
Dependent Claim
94 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: mixing said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form said composition.
Claim 15
Dependent Claim
94 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: mixing said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form said composition.
Claim 16
Dependent Claim
128 words
A solid composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 17
Dependent Claim
128 words
A solid composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 18
Dependent Claim
13 words
The solid composition of claim 11 , said step of removing comprising freeze-drying.
Claim 19
Dependent Claim
29 words
The solid composition of claim 11 , said process further comprising: performing any one or more of said steps of combining, mixing, and removing, under positive or negative pressure.
Claim 20
Independent Claim
65 words
A method for producing a solid composition, comprising: combining particulate bone with one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; mixing water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition.
Claim 21
Independent Claim
65 words
A method for producing a solid composition, comprising: combining particulate bone with one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; mixing water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition.
Claim 22
Dependent Claim
12 words
The method of claim 14 , said step of removing comprising freeze-drying.
Claim 23
Dependent Claim
27 words
The method of claim 14 , further comprising: mixing said non-liquid particulate mixture and/or said matrix composition, with one or more pharmaceutically active agents prior to removing.
Claim 24
Independent Claim
56 words
A method for producing a bone matrix composition, comprising: combining particulate bone with one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing water with said non-liquid particulate mixture to form said bone matrix composition.
Claim 25
Independent Claim
56 words
A method for producing a bone matrix composition, comprising: combining particulate bone with one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing water with said non-liquid particulate mixture to form said bone matrix composition.
Claim 26
Dependent Claim
25 words
The method of claim 17 , further comprising: mixing said non-liquid particulate mixture and/or said bone matrix composition, with one or more pharmaceutically active agents.
Claim 27
Dependent Claim
119 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form a bone matrix composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 28
Dependent Claim
119 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form a bone matrix composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 29
Dependent Claim
96 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid cellulosics to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form a bone matrix composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 30
Dependent Claim
96 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents, produced by the process comprising: combining said particulate bone with said one or more non-liquid cellulosics to produce a non-liquid particulate mixture; and mixing said water with said non-liquid particulate mixture to form a bone matrix composition, wherein said one or more pharmaceutically active agents are optionally added during any one or more of said steps of combining and mixing.
Claim 31
Dependent Claim
53 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 32
Dependent Claim
53 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose; hydroxy ethyl cellulose; and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 33
Dependent Claim
33 words
A bone matrix composition, consisting essentially of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 34
Dependent Claim
33 words
A bone matrix composition, consisting essentially of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 35
Dependent Claim
36 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 36
Dependent Claim
36 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more pharmaceutically active agents.
Claim 37
Dependent Claim
27 words
The composition of any one of claims 20 or 23 , wherein said one or more non-liquid semi-synthetic polymers comprise one or more water-soluble, non-liquid, semi-synthetic polymers.
Claim 38
Dependent Claim
31 words
The composition of any one of claims 2 , 3 , 11 , 21 , 22 , or 23 , said one or more pharmaceutically active agents comprise bone marrow cells.
Claim 39
Dependent Claim
33 words
The composition of any one of claims 2 , 3 , 11 , 21 , 22 , or 23 , said one or more pharmaceutically active agents comprise one or more angiogenic factors.
Claim 40
Dependent Claim
49 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 41
Dependent Claim
49 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 42
Dependent Claim
84 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 9.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount from about 20.0%v/v to about 90%v/v; and optionally containing one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 43
Dependent Claim
84 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 9.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount from about 20.0%v/v to about 90%v/v; and optionally containing one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 44
Dependent Claim
139 words
A solid composition, consisting essentially of one: or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose; particulate bone; water; and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, to produce a non-liquid particulate mixture; mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more angiogenic factors are optionally added during any one or more of said steps of combining and mixing.
Claim 45
Dependent Claim
139 words
A solid composition, consisting essentially of one: or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose; particulate bone; water; and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, to produce a non-liquid particulate mixture; mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more angiogenic factors are optionally added during any one or more of said steps of combining and mixing.
Claim 46
Dependent Claim
65 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 47
Dependent Claim
65 words
A bone matrix composition, consisting essentially of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 48
Dependent Claim
42 words
A bone matrix composition, consisting essentially of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 49
Dependent Claim
42 words
A bone matrix composition, consisting essentially of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 50
Dependent Claim
45 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 90 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 51
Dependent Claim
45 words
A bone matrix composition, consisting essentially of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 90 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 52
Dependent Claim
48 words
The bone matrix composition of any one of claims 1 - 6 , 9 - 22 , or 23 , said particulate bone consists of: non-demineralized particulate bone, and optionally one or more members selected from the group consisting of partially demineralized particulate bone and demineralized particulate bone.
Claim 53
Dependent Claim
36 words
The bone matrix composition of claim 8 , said particulate bone consists of non-demineralized particulate bone, and optionally one or more members selected from the group consisting of partially demineralized particulate bone and demineralized particulate bone.
Claim 54
Dependent Claim
36 words
The bone matrix composition of claim 8 , said particulate bone consists of: non-demineralized particulate bone, and optionally one or more members selected from the group consisting of partially demineralized particulate bone and demineralized particulate bone.
Claim 55
Dependent Claim
33 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; and water.
Claim 56
Dependent Claim
33 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; and water.
Claim 57
Dependent Claim
48 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 58
Dependent Claim
48 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose; particulate bone; water; and one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 59
Dependent Claim
83 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 90.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount from about 20.0%v/v to about 90%v/v; and optionally containing one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 60
Dependent Claim
83 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: methyl cellulose, carboxy methyl cellulose, hydroxy propyl cellulose, and hydroxy ethyl cellulose, in an amount of from about 0.1 wt % to about 90.0 wt %; particulate bone in an amount of from about 20.0%v/v to about 90.0%v/v; water in an amount from about 20.0%v/v to about 90%v/v; and optionally containing one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 61
Dependent Claim
138 words
A solid composition, consisting of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose; particulate bone; water; and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and ethyl cellulose, to produce a non-liquid particulate mixture, mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more angiogenic factors are optionally added during any one or more of said steps of combining and mixing.
Claim 62
Dependent Claim
138 words
A solid composition, consisting of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose; particulate bone; water; and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid, produced by the process comprising: combining said particulate bone with said one or more non-liquid members selected from the group consisting of carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and ethyl cellulose, to produce a non-liquid particulate mixture, mixing said water with said non-liquid particulate mixture to form a matrix composition, and removing water from said matrix composition to form said solid composition, wherein said one or more angiogenic factors are optionally added during any one or more of said steps of combining and mixing.
Claim 63
Dependent Claim
64 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 64
Dependent Claim
64 words
A bone matrix composition, consisting of: one or more non-liquid members selected from the group consisting of: carboxy methyl cellulose, hydroxy propyl cellulose, hydroxy ethyl cellulose, and methyl cellulose, in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 65
Dependent Claim
41 words
A bone matrix composition, consisting of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 66
Dependent Claim
41 words
A bone matrix composition, consisting of: carboxy methyl cellulose in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 67
Dependent Claim
44 words
A bone matrix composition, consisting of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 68
Dependent Claim
44 words
A bone matrix composition, consisting of: one or more non-liquid semi-synthetic polymers in an amount of from 0.1 wt % to 9.0 wt %; particulate bone; water, and optionally one or more angiogenic factors selected from the group consisting of nicotine and nicotinic acid.
Claim 69
Dependent Claim
38 words
The bone matrix composition of any one of claims 1 - 6 , 9 - 10 , 19 - 23 , 36 - 38 , 40 - 41 or 42 , said particulate bone consists of dry bone.
Claim 70
Dependent Claim
15 words
The bone matrix composition of claim 8 , said particulate bone consists of dry bone.
References Cited (Backward Citations)
US5284655A
Cited
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