US6151523A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus and procedure for measuring volumes and global and segmental corporal composition in human beings
Assignee: NTE Sener SA
•
Filing: 1998-03-04
•
Granted: 2000-11-21
•
Expires: 2018-03-04
Abstract
Abstract Apparatus and procedure for measuring volumes and global and segmental corporal composition in human beings, by means of measuring the electrical impedance at various frequencies, determining in this manner, the ratio between the intracellular water and the extracellular water volumes, the contents of total and extracellular water in each segment and the contents of the segmental lean mass. The apparatus is made up of a computer (11) which controls an electronic box (12), fed through a feeding source (14), various electrodes (13) coming out from said electronic box (12) which are placed on the body under research.
Inventors
- 👤 Javier Rosell Ferrer
- 👤 Pere Riu Costa
- 👤 Ramon Pallas Areny
- 👤 Jordi Elvira Canas
- 👤 Ramon Bragos Bardia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:47
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4869; A61B5/05; A61B5/053; A61B5/0537; A61B5/4872
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
553 words
A method for measuring volumes and global and segmental corporal composition in human beings comprising: measuring the electrical impedance at a plurality of locations corresponding to a plurality of predeteremined segments of a human body, using a minimum of four frequencies in the range of 1 kHz to 1 MHz, estimating the ratio between the total water and extracellular water volumes, both at global and segmental levels, by determining the k quotient between the impedance module at low frequency Z(BF), placed between 1 kHz and 50 kHz, and the impedance module at high frequency Z(AF), placed between 100 kHz to 10 MHz, said quotient being independent from the conditions of the measurement contour, adjusting said quotient by the least squares method, both at global and segmental levels, by the following electrical impedance expression (Z) based on the frequency (f); ##EQU20## thus determining the values R.sub.∞, R 0 , f c and α, wherein R 28 represents the resistance at infinite frequency, R 0 represents the resistance at zero frequency, f c represents the frequency at which the maximum of lm(Z) occurs and α represents the dispersion of the cells of the biological system, with which the following values are calculated: a) the ratio between the intracellular water and extracellular water volumes, given by; ##EQU21## b) the total water content of a segment i (TBW seg ,i), given by: ##EQU22## and the content of a segment i in extracellular water (ECW seg ,i) which is determined by: ##EQU23## wherein H is the height of the body in cm, K TBW is a constant of proportionality for the total water (TBW), K ECW is a constant of proportionality for the extracellular water, Ko TBWseg ,i is the independent term for segment i, Ko ECWseg ,i, is the independent term for the extracellular water (ECW) for segment i, and L' seg ,i and L' seg ,i are geometric terms to be determined for each segment I, wherein the real value (Z(∞)) corresponds to the real value of an impedance over 100 kHz and below 1 MHz for segment i, but preferably at R∞, and the real value (Z(10 kHz)) corresponds to the real value of an impedance over 10 kHz and below 50 kHz for segment i, but preferably at R 0 ; c) the content of segment i in the intracellular water which is determined by means of the subtraction of ECW seg ,i from TBW seg ,i ; d) the volume of total and extracellular water at the global level which shall be determined by the sum of the respective values of segments i; e) the content of the segmental or regional MM seg ,i and global lean mass by means of the equation ##EQU24## N and M being terms which are introduced from the lineal regression between the ratio: ##EQU25## and the value of the amount of lean mass measured by means of an alternative method and which depend on the type of human race, and D 2 eq ,seg,i, a geometric parameter of segment i; and obtaining the global value of the amount of lean mass from the sum of all the values MM seg ,i and the global fatty mass from the difference between the weight of the human body studied and the weight of the amount of global lean matter.
Claim 2
Independent Claim
553 words
A method for measuring volumes and global and segmental corporal composition in human beings comprising: measuring the electrical impedance at a plurality of locations corresponding to a plurality of predeteremined segments of a human body, using a minimum of four frequencies in the range of 1 kHz to 1 MHz, estimating the ratio between the total water and extracellular water volumes, both at global and segmental levels, by determining the k quotient between the impedance module at low frequency Z(BF), placed between 1 kHz and 50 kHz, and the impedance module at high frequency Z(AF), placed between 100 kHz to 10 MHz, said quotient being independent from the conditions of the measurement contour, adjusting said quotient by the least squares method, both at global and segmental levels, by the following electrical impedance expression (Z) based on the frequency (f); ##EQU20## thus determining the values R.sub.∞, R 0 , f c and α, wherein R 28 represents the resistance at infinite frequency, R 0 represents the resistance at zero frequency, f c represents the frequency at which the maximum of lm(Z) occurs and α represents the dispersion of the cells of the biological system, with which the following values are calculated: a) the ratio between the intracellular water and extracellular water volumes, given by; ##EQU21## b) the total water content of a segment i (TBW seg ,i), given by: ##EQU22## and the content of a segment i in extracellular water (ECW seg ,i) which is determined by: ##EQU23## wherein H is the height of the body in cm, K TBW is a constant of proportionality for the total water (TBW), K ECW is a constant of proportionality for the extracellular water, Ko TBWseg ,i is the independent term for segment i, Ko ECWseg ,i, is the independent term for the extracellular water (ECW) for segment i, and L' seg ,i and L' seg ,i are geometric terms to be determined for each segment I, wherein the real value (Z(∞)) corresponds to the real value of an impedance over 100 kHz and below 1 MHz for segment i, but preferably at R∞, and the real value (Z(10 kHz)) corresponds to the real value of an impedance over 10 kHz and below 50 kHz for segment i, but preferably at R 0 ; c) the content of segment i in the intracellular water which is determined by means of the subtraction of ECW seg ,i from TBW seg ,i ; d) the volume of total and extracellular water at the global level which shall be determined by the sum of the respective values of segments i; e) the content of the segmental or regional MM seg ,i and global lean mass by means of the equation ##EQU24## N and M being terms which are introduced from the lineal regression between the ratio: ##EQU25## and the value of the amount of lean mass measured by means of an alternative method and which depend on the type of human race, and D 2 eq ,seg,i, a geometric parameter of segment i; and obtaining the global value of the amount of lean mass from the sum of all the values MM seg ,i and the global fatty mass from the difference between the weight of the human body studied and the weight of the amount of global lean matter.
Claim 3
Dependent Claim
42 words
A method according the claim 1, comprising determining the volume of total and extracellular water at the global level using an RSI (right side impedance) as if it was a segment conveniently considering the specific parameters of the TBW and ECW formulas.
Claim 4
Dependent Claim
172 words
An apparatus for measuring the electrical impedance for the method of claim 1 comprising a backplane which interconnects an electrical source and four signal generator boards, wherein a first signal generator board generates at least two of said frequencies as well as reference signals for demodulation, a second board for patient interface converts the tension signals generated into current, a third detection signal board is made up of a differential amplifier and a gain amplifier with selectable gains via software and a fourth A/D obtention board is provided with an A/D converter for sampling for data obtention, wherein said electrical source is adapted to be connected to the human body under study by means of a multiplexor which permits any pair of electrodes to be connected to the said source, by connecting each one of the electrodes to an input buffer, whilst each one of their outputs is connected to a multiplexor circuit which feeds a differential amplifier, and wherein the control of the system is conducted by means of a microcontroller.
Claim 5
Dependent Claim
27 words
Apparatus according to claim 3, further comprising an accelerometer which measures acceleration to which the body has been subjected, in a synchronized manner with the impedance measure.
Claim 6
Dependent Claim
139 words
A process for measuring the volume and global and segmental corporal compositions in human beings, comprising: measuring the electrical impedance at a plurality of locations corresponding to a plurality of predetermined segments of a human body, using various frequencies within the range between 1 kHz and 1 MHz; estimating the ratio between total water and extracellular water volumes, both at global and segmental levels; adjusting the estimated ratio at both global and segmental levels using the least squares method, wherein preselected parameters can be used to determine the ratio between intracellular and extracellular water volumes, the total water content of one or more predetermined segments, the intracellular water content of said one or more predetermined segments, and the volume of total and extracellular water at the global level, by adding and/or substracting the values associated with said predetermined segments.
Claim 7
Dependent Claim
139 words
A process for measuring the volume and global and segmental corporal compositions in human beings, comprising: measuring the electrical impedance at a plurality of locations corresponding to a plurality of predetermined segments of a human body, using various frequencies within the range between 1 kHz and 1 MHz; estimating the ratio between total water and extracellular water volumes, both at global and segmental levels; adjusting the estimated ratio at both global and segmental levels using the least squares method, wherein preselected parameters can be used to determine the ratio between intracellular and extracellular water volumes, the total water content of one or more predetermined segments, the intracellular water content of said one or more predetermined segments, and the volume of total and extracellular water at the global level, by adding and/or substracting the values associated with said predetermined segments.
Claim 8
Dependent Claim
30 words
The process of claim 5, wherein said parameters are used to determine the ratio, at both global and segmental levels, of lean mass to fatty mass within said human being.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-11-21 | 2004-05-22 | 2004-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-11-21 | 2008-05-22 | 2008-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-11-21 | 2012-05-22 | 2012-11-21 | $7700.00 | Window Closed / Lapsed |