Abstract There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.
A system for sensing insulin demand of a patient, comprising: stimulating means for delivering stimulating pulses to the pancreas of said patient; sensing means for sensing the electrical responses of said pancreas to said stimulating pulses and obtaining signals representative of said responses; processing means for processing said signals and deriving therefrom a measure of the insulin demand of said patient; insulin means for delivering insulin to said patient; and delivery control means for controlling said insulin means to deliver insulin as a function of said insulin demand measure.
Claim 2
Independent Claim
89 words
A system for sensing insulin demand of a patient, comprising: stimulating means for delivering stimulating pulses to the pancreas of said patient; sensing means for sensing the electrical responses of said pancreas to said stimulating pulses and obtaining signals representative of said responses; processing means for processing said signals and deriving therefrom a measure of the insulin demand of said patient; insulin means for delivering insulin to said patient; and delivery control means for controlling said insulin means to deliver insulin as a function of said insulin demand measure.
Claim 3
Dependent Claim
34 words
The system as described in claim 1, wherein said system is implantable, and further comprising external means for communicating to said implantable system commands for stimulating said pancreas and obtaining said insulin demand measure.