US6135955A
Expired / Lapsed
US
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Apparatus and methods for determining spatial coordinates of radiolabeled tissue using gamma-rays and associated characteristic x-rays
Assignee: CARE WIDE MEDICAL PRODUCTS Corp
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Filing: 1997-10-27
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Granted: 2000-10-24
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Expires: 2017-10-27
Abstract
Abstract A system and method for diagnostic testing of structures within a body, e.g., organs within the body of a living being, which has been provided with a radioactive imaging agent, e.g., a radiotracer, to cause the structure to produce gamma rays, associated characteristic x rays, and a continuum of Compton-scattered photons. The system includes a radiation receiving device, e.g., a hand-held probe or camera, an associated signal processor, and an analyzer. The radiation receiving device is arranged to be located adjacent the body and the structure for receiving gamma rays and characteristic x rays emitted from the structure and for providing a processed electrical signal representative thereof. The processed electrical signal includes a first portion representing the characteristic x rays received and a second portion representing the gamma rays received. In a preferred embodiment of the invention the signal processor removes the signal corresponding to the Compton-scattered photons from the electrical signal in the region of the full-energy gamma ray and the characteristic x ray. The analyzer is arranged to selectively use the x-ray portion of said processed signal to provide near-field information about the structure, to selectively use both the x-ray and the gamma-ray portions of said processed signal to provide near-field and far-field information about the structure, and to selectively use the gamma-ray portion of said processed signal to provide extended field information about the structure.
Inventors
- 👤 Norman Madden
- 👤 Richard Pehl
- 👤 Robert G. Carroll
- 👤 Louis McKellar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:27
CPC Classifications
A; A61; A61B; A61B6/00; A61B6/48; A61B6/482; A61B6/40; A61B6/4057; A61B6/42; A61B6/4208; A61B6/4258; G; G01; G01T; G01T1/00; G01T1/16; G01T1/161; A61B90/00; A61B90/39; A61B2090/392
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
203 words
A system for determining the density of a mass of tissue of interest, said system comprising radiation detecting means, signal processing means and signal analyzing means, wherein the tissue of interest is intervening between the radiation detecting means and underlying tissue which has been provided with at least one radiolabelled tracer producing gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton scattered photons, said radiation detecting means being positionable to a location adjacent the intervening tissue of interest for detecting the photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through the intervening tissue, said radiation detecting means providing an electrical signal representative of the received photons, said signal processing means processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed electrical signal including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received, said analyzing means, comprising spectral line shape analyzing means, being arranged for analyzing at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.
Claim 2
Independent Claim
203 words
A system for determining the density of a mass of tissue of interest, said system comprising radiation detecting means, signal processing means and signal analyzing means, wherein the tissue of interest is intervening between the radiation detecting means and underlying tissue which has been provided with at least one radiolabelled tracer producing gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton scattered photons, said radiation detecting means being positionable to a location adjacent the intervening tissue of interest for detecting the photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through the intervening tissue, said radiation detecting means providing an electrical signal representative of the received photons, said signal processing means processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed electrical signal including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received, said analyzing means, comprising spectral line shape analyzing means, being arranged for analyzing at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.
Claim 3
Dependent Claim
55 words
The system of claim 1 wherein said processed signal includes at least one asymmetrical portion and wherein said spectral line shape analyzing means determines the degree of asymmetry of at least a selected one of said first and second portions of said processed signal to provide the indication of the density of the intervening tissue.
Claim 4
Dependent Claim
94 words
The system of claim 1 wherein said processed signal has a shape and wherein spectral line shape analyzing means comprising means defining plural reference shapes, at least one of said reference shapes representing at least a selected one of said first and second portions of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, said spectral line shape analyzing means comparing the shape of the at least one portion of said processed signal to at least one of said plural reference shapes.
Claim 5
Dependent Claim
122 words
The system of claim 1 wherein said processor signal has a shape and wherein said spectral line shape analyzing means comprises means defining plural reference shapes, at least one of said reference shapes representing the gamma-ray portion of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and at least another of said reference shapes representing the characteristic x-ray portion of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, said spectral line shape analyzing means comparing the shape of the at least one portion of said processed signal to at least one of said plural reference shapes.
Claim 6
Independent Claim
180 words
A method for determining the density of a mass of tissue of interest, wherein the tissue of interest is intervening between an exterior or exposed tissue plane and tissue underlying the tissue plane, comprising: a) providing the underlying tissue with a radiotracer that produces gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton-scattered photons; b) providing radiation detecting means adjacent the tissue of interest for detecting photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through intervening tissue and for providing an electrical signal representative of the received photons; c) processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed signal having a shape and including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received; and d) analyzing the spectral line shape of at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.
Claim 7
Independent Claim
180 words
A method for determining the density of a mass of tissue of interest, wherein the tissue of interest is intervening between an exterior or exposed tissue plane and tissue underlying the tissue plane, comprising: a) providing the underlying tissue with a radiotracer that produces gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton-scattered photons; b) providing radiation detecting means adjacent the tissue of interest for detecting photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through intervening tissue and for providing an electrical signal representative of the received photons; c) processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed signal having a shape and including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received; and d) analyzing the spectral line shape of at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.
Claim 8
Dependent Claim
50 words
The method of claim 5 wherein said processed signal includes at least one asymmetrical portion and wherein said step d) is accomplished by determining the degree of asymmetry of the at least a selected portion of said processed signal to provide the indication of the density of the intervening tissue.
Claim 9
Dependent Claim
80 words
The method of claim 6 additionally comprising providing data defining plural reference shapes, with at least one of said reference shapes representing at least a selected one of said first and second portions of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and wherein the shape of the at least one portion of said processed signal is compared to at least one of said plural reference shapes.
Claim 10
Dependent Claim
107 words
The method of claim 6 additionally comprising providing data defining plural reference shapes, with at least one of said reference shapes representing the gamma-ray portion of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and at least another of said reference shapes representing the characteristic x-ray portion of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and wherein the shape of the at least one portion of said processed signal is compared to at least one of said plural reference shapes.
References Cited (Backward Citations)
US3936646A
Cited
US3843881A
Cited
US3955088A
Cited
US4124804A
Cited
US4150289A
Cited
US4340818A
Cited
US4419585A
Cited
US4489426A
Cited
US4782840A
Cited
US4873632A
Cited
US4671256A
Cited
US4682604A
Cited
US4868856A
Cited
US4949365A
Cited
US4893013A
Cited
US4801803A
Cited
US5165410A
Cited
US5003980A
Cited
US4995396A
Cited
US4959547A
Cited
US5036210A
Cited
US5068883A
Cited
US5148040A
Cited
US5519221A
Cited
US5694933A
Cited
US5813985A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-24 | 2004-04-24 | 2004-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-24 | 2008-04-24 | 2008-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-24 | 2012-04-24 | 2012-10-24 | $7700.00 | Window Closed / Lapsed |