US6120474A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood component-recovering apparatus and a method for recovering blood components using the same
Assignee: Nissho Corp
•
Filing: 1998-12-14
•
Granted: 2000-09-19
•
Expires: 2018-12-14
Abstract
Abstract The present invention provides a blood component-recovering apparatus and a method for high-yield recovery of leukocytes captured in a filter of the blood component-recovering apparatus. The blood component-recovering apparatus includes a housing accommodating (a) a filtration portion charged with (b) a filter which is capable of passing erythrocytes but capturing leukocytes and (c) a pressing member for pressing the filter, the housing being provided in the sidewall thereof with (d) a blood flow inlet and (e) a blood flow outlet communicating with the filtration portion. The housing of the blood component-recovering apparatus is further provided in the upper wall thereof with (f) a means capable of transferring, or moving, the pressing member vertically. The pressing member of the blood component-recovering apparatus is transferred downward while a blood containing blood components is passed through the filtration portion. The pressing member is then transferred upward to increase the volume of the filtration portion, and a washing solution is then passed through the filter to recover leukocytes.
Inventors
- 👤 Morihiro Okuda
- 👤 Nobuo Takagi
- 👤 Daisuke Fukuta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:19
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
64 words
A blood component-recovering apparatus comprising a housing in which is accommodated (a) a filtration portion charged with (b) a filter which is capable of passing erythrocytes but of capturing leukocytes and (c) a pressing member for pressing said filter, said housing being provided in the sidewall thereof with (d) a blood flow inlet and (e) a blood flow outlet communicating with said filtration portion.
Claim 2
Dependent Claim
64 words
A blood component-recovering apparatus comprising a housing in which is accommodated (a) a filtration portion charged with (b) a filter which is capable of passing erythrocytes but of capturing leukocytes and (c) a pressing member for pressing said filter, said housing being provided in the sidewall thereof with (d) a blood flow inlet and (e) a blood flow outlet communicating with said filtration portion.
Claim 3
Dependent Claim
31 words
The blood component-recovering apparatus of claim 1, wherein the housing is provided in the upper wall thereof with (f) a means capable of moving the pressing member in a vertical direction.
Claim 4
Dependent Claim
64 words
The blood component-recovering apparatus of claim 1, wherein (c) the pressing member is capable of being arranged in a downward position while a blood containing blood components is passed through the filtration portion, and of being transferred to an upward position to increase the volume of said filtration portion, and to allow a washing solution to be passed through said filter to recover leukocytes.
Claim 5
Dependent Claim
140 words
The blood component-recovering apparatus according to claim 1, wherein (f) the means capable of moving the pressing member in a vertiacl direction comprises (g) a bolt portion including (h) a rod-shaped member having (i) a male screw formed on the sidewall thereof extending in a longitudinal direction above the pressing member; (j) a hole through which the rod-shaped member can be transferred vertically and being formed in the bottom of (k) a concave portion provided on the upper wall of the housing; and (l) a nut portion comprising a cylinder portion and a grasping portion, said cylinder portion having (m) a female screw formed on the inner wall thereof and having an outer diameter which permits said cylinder portion to be inserted into said concave portion and being capable of being screw-engaged with the male screw in said bolt portion.
Claim 6
Dependent Claim
115 words
The blood component-recovering apparatus according to claim 1, wherein (f) the means capable of moving the pressing member in a vertical direction comprises (n) a rod-shaped member extending in a longitudinal direction above the pressing member and having (o) a lock portion at the bottom and (p) a male screw formed on the sidewall thereof; (q) a chamber provided on the pressing member, having (r) a first hole through which said rod-shaped member penetrates and accommodating said lock portion; and (s) a female screw formed on the inner wall of (t) a second hole provided on the upper wall of housing and being capable of being screw-engaged with the male screw of said rod-shaped member.
Claim 7
Dependent Claim
42 words
The blood component-recovering apparatus according to claim 4 or 5, wherein the pressing member is in the form of a disk provided in a side edge thereof with (u) an O-ring capable of sliding liquidtightly along the inner wall of the housing.
Claim 8
Dependent Claim
23 words
The blood component-recovering apparatus according to claim 1, wherein the housing comprises (v) an upper lid portion and (w) a lower lid portion.
Claim 9
Dependent Claim
83 words
The blood component-recovering apparatus according to claim 7, wherein (v) said upper lid portion accommodates (x) a spring body for pressing (a) said filtration portion and (c) said pressing member is connected to the end of said spring body and is capable of being positioned in the inside of (w) said lower lid portion, and (w) said lower lid portion accommodates said filter, is provided with (d) a blood inlet and (e) a blood outlet and is engageable with the upper lid portion.
Claim 10
Dependent Claim
67 words
The blood component-recovering apparatus according to claim 7, wherein (v) said upper lid portion accommodates (x) a spring body for pressing (a) said filtration portion, and (w) siad lower lid portion accommodates (b) said filtration portion and (c) a pressing member arranged on the filtration portion and is provided with (d) a blood inlet and (e) a blood outlet and is engageable with the upper lid portion.
Claim 11
Dependent Claim
88 words
The blood component-recovering apparatus according to claim 9 or 10, wherein an outer wall of the lower lid portion is provided with a protruding portion, and a sidewall of the upper lid portion is provided with a hole portion consisting of a first hole extending lengthwise in a longitudinal direction and at least one second hole extending lengthwise in a latitudinal direction to and communicating with said lengthwise long hole, and the protruding portion being slideable along said first hole and of being locked with said second hole.
Claim 12
Dependent Claim
37 words
The blood component-recovering apparatus according to claim 1, wherein the filter is accommodated in a bag made of flexible resin, and said bag is connected to a blood flow inlet tube and a blood flow outlet tube.
Claim 13
Dependent Claim
40 words
The blood component-recovering apparatus according to claim 1, wherein the filter comprises a fiber aggregate of fibers having a fiber diameter of 25 μm or less said fiber aggregate having a bulk density of 0.05 to 0.50 g/cm 3 .
Claim 14
Dependent Claim
50 words
The blood component-recovering apparatus according to claim 1, wherein the filter comprises a multi-layer fiber aggregate, and at least one layer comprises a fiber aggregate of fibers having a fiber diameter of 25 μm or less said fiber aggregate having a bulk density of 0.05 to 0.50 g/cm 3 .
Claim 15
Dependent Claim
52 words
The blood component-recovering apparatus according to claim 1, wherein the inner volume of the filtration portion in the blood component-recovering apparatus when said pressing means is in an upward position is at least 1.10-fold relative to the inner volume of the filtration portion when said pressing means is in a downward position.
Claim 16
Independent Claim
53 words
A method of recovering blood components, which comprises passing a blood containing blood components through a filtration portion charged with a filter which is capable of passing erythrocytes but capturing leukocytes, thereafter enlarging the inner volume of said filtration portion, and then passing a washing solution through said filtration portion to recover leukocytes.
Claim 17
Independent Claim
53 words
A method of recovering blood components, which comprises passing a blood containing blood components through a filtration portion charged with a filter which is capable of passing erythrocytes but capturing leukocytes, thereafter enlarging the inner volume of said filtration portion, and then passing a washing solution through said filtration portion to recover leukocytes.
Claim 18
Dependent Claim
37 words
The method of recovering blood components according to claim 15, wherein the filter is accommodated in a bag made of flexible resin and said bag is connected to a blood inlet tube and a blood outlet tube.
Claim 19
Dependent Claim
42 words
The method of recovering blood components according to claim 15, wherein the filter comprises a fiber aggregate of fibers having a fiber diameter of 25 μm or less, said fiber aggregate having a bulk density of 0.05 to 0.50 g/cm 3 .
Claim 20
Dependent Claim
52 words
The method of recovering blood components according to claim 15, wherein the filter comprises a multi-layer fiber aggregate, and at least one layer comprises a fiber aggregate of fibers having a fiber diameter of 25 μm or less said fiber aggregate having a bulk density of 0.05 to 0.50 g/cm 3 .
Claim 21
Dependent Claim
48 words
The method of recovering blood components according to claim 15, wherein the inner volume of the filtration portion in the blood component-recovering apparatus after being enlarged is at least 1.10-fold relative to the inner volume of the filtration portion before blood is passed through the blood component-recovering apparatus.
Claim 22
Dependent Claim
17 words
The method of recovering blood components according to claim 15, wherein said blood is umbilical cord blood.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-19 | 2004-03-20 | 2004-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-19 | 2008-03-20 | 2008-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-19 | 2012-03-20 | 2012-09-19 | $7700.00 | Window Closed / Lapsed |