Patent US4392493A successfully refreshed from Google Patents.
US6059714A
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US
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Radioactive medical devices
Assignee: Implant Sciences Corp
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Filing: 1999-03-26
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Granted: 2000-05-09
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Expires: 2019-03-26
Abstract
Abstract An implantable medical device according to the present invention comprises a body, such as a stent or a wire, having a radioisotope or non-radioactive precursor isotope associated with the body. The isotope preferably is disposed on the body using an efficient deposition method, such as an effusion cell. The method reduces the waste of costly isotopes and reduces the buildup of hazardous material in the apparatus. A metal layer may be deposited simultaneously with or subsequent to deposition of the isotope to encapsulate the radioactive isotope.
Inventors
- 👤 Anthony J. Armini
- 👤 Stephen N. Bunker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:49
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002; G; G21; G21G; G21G4/00; G21G4/04; G21G4/06; G21G4/08; A61N2005/1019
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
39 words
A method for manufacturing a radioactive medical device, comprising heating a radioactive isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 2
Independent Claim
39 words
A method for manufacturing a radioactive medical device, comprising heating a radioactive isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein the layer of atoms disposed on the body is less than about 250 Å thick.
Claim 4
Dependent Claim
29 words
The method of claim 1, wherein the radioactive isotope is selected from the group consisting of 32 P, 90 Y, 103 Pd, 125 I, 131 Cs, and 169 Yb.
Claim 5
Dependent Claim
36 words
The method of claim 1, wherein the intensity of radioactivity of the atoms disposed on the body is measured using a nuclear radiation detector substantially simultaneously to disposing the layer of the atoms on the body.
Claim 6
Dependent Claim
28 words
The method of claim 1, further comprising disposing an adhesion layer onto the body prior to disposing the layer of the atoms of the isotope on the body.
Claim 7
Dependent Claim
14 words
The method of claim 1, further comprising disposing a metal layer onto the body.
Claim 8
Dependent Claim
23 words
The method of claim 6, wherein disposing the metal layer occurs substantially simultaneously with depositing the layer of the atoms onto the body.
Claim 9
Dependent Claim
33 words
The method of claim 6, wherein disposing the metal layer is performed by a method selected from the group consisting of thermal boat evaporation, electron beam evaporation, sputtering, and a second effusion cell.
Claim 10
Dependent Claim
36 words
The method of claim 6, wherein said metal layer comprises a biocompatible material including one or more materials from the group consisting of titanium, titanium alloy, gold, copper, tantalum, stainless steel, cobalt-chrome alloy, platinum, and palladium.
Claim 11
Dependent Claim
28 words
The method of claim 6, further comprising disposing an adhesion layer onto the body prior to disposing the layer of the atoms of the isotope on the body.
Claim 12
Dependent Claim
13 words
The method of claim 6, wherein the metal layer encapsulates the radioactive isotope.
Claim 13
Independent Claim
39 words
A method for manufacturing a medical device, comprising heating a non-radioactive precursor isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 14
Independent Claim
39 words
A method for manufacturing a medical device, comprising heating a non-radioactive precursor isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 15
Dependent Claim
21 words
The method of claim 12, wherein the layer of atoms disposed on the body is less than about 250 Å thick.
Claim 16
Dependent Claim
32 words
The method of claim 12, wherein the non-radioactive precursor isotope is selected from the group consisting of 31 P, 89 Y, 102 Pd, 185 Re, 187 Re, 130 Ba, and 168 Yb.
Claim 17
Dependent Claim
33 words
The method of claim 12, further comprising exposing the body having the layer of atoms disposed thereon to a source of thermal neutrons under conditions sufficient to activate the atoms of the isotope.
Claim 18
Dependent Claim
28 words
The method of claim 12, further comprising disposing an adhesion layer onto the body prior to disposing the layer of the atoms of the isotope on the body.
Claim 19
Dependent Claim
14 words
The method of claim 12, further comprising disposing a metal layer onto the body.
Claim 20
Dependent Claim
23 words
The method of claim 17, wherein disposing a metal layer occurs substantially simultaneously with disposing the layer of the atoms onto the body.
Claim 21
Dependent Claim
33 words
The method of claim 17, wherein said metal layer comprises one or more materials selected from the group consisting of titanium, titanium alloy, gold, copper, tantalum, stainless steel, cobalt-chrome alloy, platinum, and palladium.
Claim 22
Dependent Claim
33 words
The method of claim 17, wherein disposing a metal layer is performed by a method selected from the group consisting of thermal boat evaporation, electron beam evaporation, sputtering, and a second effusion cell.
Claim 23
Dependent Claim
20 words
The method of claim 17, wherein the metal layer does not comprise a material which neutron activates to long-lived radioisotopes.
Claim 24
Dependent Claim
14 words
The method of claim 17, wherein the metal layer encapsulates the non-radioactive precursor isotope.
Claim 25
Dependent Claim
36 words
A medical device manufactured by heating a non-radioactive precursor isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 26
Dependent Claim
36 words
A medical device manufactured by heating a non-radioactive precursor isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 27
Dependent Claim
28 words
The medical device of claim 23, which is rendered radioactive by exposing the device to a source of thermal neutrons under conditions sufficient to activate the precursor isotope.
Claim 28
Dependent Claim
36 words
A radioactive medical device manufactured by heating a radioactive isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
Claim 29
Dependent Claim
36 words
A radioactive medical device manufactured by heating a radioactive isotope in an effusion cell under conditions sufficient to vaporize atoms of the isotope; and disposing a layer of the atoms of the isotope on a body.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-05-09 | 2003-11-08 | 2004-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-05-09 | 2007-11-08 | 2008-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-05-09 | 2011-11-08 | 2012-05-09 | $7700.00 | Window Closed / Lapsed |