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US6010700A
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Polypeptides p57 or p9.5 of Borna disease virus and their use for diagnosis and immunization
Assignee: Individual
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Filing: 1997-02-21
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Granted: 2000-01-04
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Expires: 2017-02-21
Abstract
Abstract The invention involves polypeptides which correspond to amino acid sequences of protein p57 or protein p9.5 of Borna disease virus. These polypeptides, as well as DNA and RNA fragments are used in test kits and vaccines.
Inventors
- 👤 Jurgen A. Richt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:31
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61P; A61P25/00; A61P31/00; A61P31/12; A61K; A61K39/00; A61K48/00; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/00022; Y; Y10; Y10S; Y10S435/00; Y10S435/975
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
40 words
A method of detecting antibody indicative of infection by Borna disease virus, comprising contacting a sample with a polypeptide comprising the sequence of the C-terminal region of p57, under conditions for antibody binding, and detecting antibodies bound to said polypeptide.
Claim 2
Independent Claim
40 words
A method of detecting antibody indicative of infection by Borna disease virus, comprising contacting a sample with a polypeptide comprising the sequence of the C-terminal region of p57, under conditions for antibody binding, and detecting antibodies bound to said polypeptide.
Claim 3
Dependent Claim
12 words
The method of claim 1, wherein the polypeptide comprises SEQ ID NO:3.
Claim 4
Dependent Claim
10 words
The method of claim 1, wherein the sample is serum.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein the detecting is performed using ELISA, Western blot, RIA, or dot blot.
Claim 6
Dependent Claim
38 words
A test kit useful in determining an antibody directed against Borna disease virus, comprising a polypeptide comprising the sequence of the C-terminal region of p57 and a labeled substance specific for complexes of said antibody and said polypeptide.
Claim 7
Dependent Claim
38 words
A test kit useful in determining an antibody directed against Borna disease virus, comprising a polypeptide comprising the sequence of the C-terminal region of p57 and a labeled substance specific for complexes of said antibody and said polypeptide.
Claim 8
Dependent Claim
13 words
The test kit of claim 5, wherein the polypeptide comprises SEQ ID NO:3.
Claim 9
Dependent Claim
23 words
The test kit of claim 6, wherein the kit comprises the components for performing an ELISA, Western blot, RIA, or dot blot test.
Claim 10
Dependent Claim
22 words
The test kit of claim 6, wherein the labeled substance is a labeled antibody which specifically binds the antibody to be determined.
Claim 11
Dependent Claim
23 words
The test kit of claim 8, wherein the label is an enzyme which can catalyze a reaction resulting in a colored end product.
Claim 12
Dependent Claim
16 words
An isolated polypeptide comprising the sequence of SEQ ID NO. 1 or SEQ ID NO. 3.
Claim 13
Dependent Claim
16 words
An isolated polypeptide comprising the sequence of SEQ ID NO. 1 or SEQ ID NO. 3.
Claim 14
Dependent Claim
9 words
An immunogenic composition comprising the polypeptide of claim 10.
Claim 15
Dependent Claim
16 words
An isolated polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 3.
Claim 16
Dependent Claim
16 words
An isolated polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 3.
Claim 17
Independent Claim
53 words
A method for inducing antibodies to a Borna Disease Virus in a subject comprising the step of immunizing the subject with a composition comprising a polypeptide consisting of the sequence set forth in SEQ ID NO: 3 fused to a non-BDV polypeptide in an amount sufficient to induce antibody production in said subject.
Claim 18
Independent Claim
53 words
A method for inducing antibodies to a Borna Disease Virus in a subject comprising the step of immunizing the subject with a composition comprising a polypeptide consisting of the sequence set forth in SEQ ID NO: 3 fused to a non-BDV polypeptide in an amount sufficient to induce antibody production in said subject.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-01-03 | 2003-07-05 | 2004-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-01-03 | 2007-07-05 | 2008-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-01-03 | 2011-07-05 | 2012-01-04 | $7700.00 | Window Closed / Lapsed |