US5948639A
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TGF-β pathway genes
Assignee: Millennium Pharmaceuticals Inc
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Filing: 1997-04-10
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Granted: 1999-09-07
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Expires: 2017-04-10
Abstract
Abstract The invention provides isolated nucleic acids molecules, designated EMI1 nucleic acid molecules, which encode proteins involved in growth factor, e.g., TGF-β, cell signaling. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing EMI1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an EMI1 gene has been introduced or disrupted. The invention still further provides isolated EMI1 proteins, fusion proteins, antigenic peptides and anti-EMI1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
Inventors
- 👤 Carlos J. Gimeno
- 👤 Dean A. Falb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:56
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4702; C07K14/4703; A; A01; A01K; A01K2217/00; A01K2217/05; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
17 words
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
Claim 2
Dependent Claim
17 words
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
Claim 3
Dependent Claim
17 words
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3 or the complement thereof.
Claim 4
Dependent Claim
17 words
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3 or the complement thereof.
Claim 5
Dependent Claim
27 words
An isolated nucleic acid molecule comprising the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98375 or the complement thereof.
Claim 6
Dependent Claim
27 words
An isolated nucleic acid molecule comprising the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98375 or the complement thereof.
Claim 7
Dependent Claim
21 words
An isolated nucleic acid molecule comprising the coding region of the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
Claim 8
Dependent Claim
21 words
An isolated nucleic acid molecule comprising the coding region of the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
Claim 9
Dependent Claim
18 words
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO-2, or the complement thereof.
Claim 10
Dependent Claim
18 words
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO-2, or the complement thereof.
Claim 11
Dependent Claim
16 words
An isolated nucleic acid molecule encoding a SEQ ID NO:2 fusion protein, or the complement thereof.
Claim 12
Dependent Claim
16 words
An isolated nucleic acid molecule encoding a SEQ ID NO:2 fusion protein, or the complement thereof.
Claim 13
Dependent Claim
22 words
An isolated nucleic acid molecule comprising a naturally-occurring allelic variant of the nucleotide sequence of SEQ ID NO:1, or the complement thereof.
Claim 14
Dependent Claim
22 words
An isolated nucleic acid molecule comprising a naturally-occurring allelic variant of the nucleotide sequence of SEQ ID NO:1, or the complement thereof.
Claim 15
Dependent Claim
21 words
A vector comprising the isolated nucleic acid molecule of any one of claims 1, 2, 3, 4, 5, 6, or 7.
Claim 16
Dependent Claim
11 words
The vector of claim 8, which is a recombinant expression vector.
Claim 17
Dependent Claim
11 words
A host cell containing the recombinant expression vector of claim 9.
Claim 18
Dependent Claim
9 words
A host cell containing the vector of claim 8.
Claim 19
Dependent Claim
32 words
A method for expressing a polypeptide, comprising transforming a host cell with the vector of claim 8, and culturing said host cell in a suitable medium such that said polypeptide is expressed.
Claim 20
Dependent Claim
17 words
The method of claim 12, further comprising isolating said polypeptide from the medium of the host cell.
Claim 21
Dependent Claim
18 words
An isolated nucleic acid molecule consisting of the nulcleotide sequence of SEQ ID NO:1, or the complement thereof.
Claim 22
Dependent Claim
18 words
An isolated nucleic acid molecule consisting of the nulcleotide sequence of SEQ ID NO:1, or the complement thereof.
Claim 23
Dependent Claim
18 words
An isolated nucleic acid molecule consisting of the nucleotide sequence of SEQ ID NO:3, or the complement thereof.
Claim 24
Dependent Claim
18 words
An isolated nucleic acid molecule consisting of the nucleotide sequence of SEQ ID NO:3, or the complement thereof.
Claim 25
Dependent Claim
28 words
An isolated nucleic acid molecule consisting of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98375, or the complement thereof.
Claim 26
Dependent Claim
28 words
An isolated nucleic acid molecule consisting of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98375, or the complement thereof.
Claim 27
Dependent Claim
23 words
An isolated nucleic acid molecule consisting of a naturally-occurring allelic variant of the nucleotide sequence of SEQ ID NO:1, or the complement thereof.
Claim 28
Dependent Claim
23 words
An isolated nucleic acid molecule consisting of a naturally-occurring allelic variant of the nucleotide sequence of SEQ ID NO:1, or the complement thereof.
References Cited (Backward Citations)
No citation records indexed.
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| 3.5 Years (Year 4) | 2002-09-06 | 2003-03-08 | 2003-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-09-06 | 2007-03-08 | 2007-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-09-06 | 2011-03-08 | 2011-09-07 | $7700.00 | Window Closed / Lapsed |