US5873366A
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US
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Method for transmyocardial revascularization
Assignee: Individual
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Filing: 1996-11-07
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Granted: 1999-02-23
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Expires: 2016-11-07
Abstract
Abstract A method for performing transmyocardial revascularization (TMR) uses a cardioplegic agent to briefly stop the heartbeat long enough to create 10 to 40 carefully placed transmyocardial blood flow channels using a laser. The cardioplegic agent used may be adenosine or an adenosine triphosphate-sensitive potassium channel opener, such as aprikalim, or a standard hyperkalemic cardioplegic agent. The temporarily induced motionlessness of the heart allows accurate and efficient placement of the blood flow channels, while the short duration of the cardioplegic effect obviates the need for cardiopulmonary bypass. The blood flow channels can be formed from the exterior or the interior of the heart. Preferably, the TMR procedure is performed using an infrared laser, such as a CO 2 laser with an articulated-arm waveguide or a pulsed Nd:YAG laser with a flexible fiberoptic delivery system, or a near infrared laser, such as a holmium:YAG or erbium laser with a flexible fiberoptic delivery system, because of their ability to efficiently ablate clearly defined passages through myocardial tissue without inducing significant thermal damage to the surrounding myocardium. The laser delivery device or a separate probe can be used to verify the depth of the blood flow channels and their connection with the ventricular chamber. The heart resumes beating spontaneously after reperfusion, with no need for defibrillation or cardioversion. The TMR procedure can be performed by a cardiac or thoracic surgeon using standard open-chest surgical techniques or using a minimally invasive surgical approach or by an interventional cardiologist using a percutaneous transluminal intravascular approach.
Inventors
- 👤 Nicholas Chim
- 👤 Marilyn M. Chou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:52
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B17/00; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B2017/00247; A61B17/22; A61B2017/22082; A61B2018/00315; A61B2018/00345; A61B2018/00351; A61B2018/00392
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
80 words
A method of performing transmyocardial revascularization on heart comprising the steps of: (a) temporarily stopping the heart from beating by inducing a brief period of asystole with a duration of less than approximately one minute; (b) creating at least one blood flow channel within a wall of the heart during said brief period of asystole, said at least one blood flow channel having a fluid connection with a chamber of the heart; and (c) allowing the heart to resume beating.
Claim 2
Independent Claim
80 words
A method of performing transmyocardial revascularization on heart comprising the steps of: (a) temporarily stopping the heart from beating by inducing a brief period of asystole with a duration of less than approximately one minute; (b) creating at least one blood flow channel within a wall of the heart during said brief period of asystole, said at least one blood flow channel having a fluid connection with a chamber of the heart; and (c) allowing the heart to resume beating.
Claim 3
Dependent Claim
37 words
The method of claim 1 wherein step (a) comprises infusing the heart with a cardioplegic agent having a short half life to induce a brief period of asystole with a duration of less than approximately one minute.
Claim 4
Dependent Claim
20 words
The method of claim 2 wherein said brief period of asystole has a duration of less than approximately twenty seconds.
Claim 5
Dependent Claim
29 words
The method of claim 2 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a concentration sufficient to induce asystole in the heart.
Claim 6
Dependent Claim
26 words
The method of claim 4 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a dosage of approximately 0.15-0.25 mg/kg.
Claim 7
Dependent Claim
43 words
The method of claim 2 further comprising the step of: (d) probing said at least one blood flow channel during said period of asystole to verify the fluid connection between said at least one blood flow channel and the chamber of the heart.
Claim 8
Dependent Claim
16 words
The method of claim 1 wherein steps (a), (b) and (c) are performed without cardiopulmonary bypass.
Claim 9
Dependent Claim
22 words
The method of claim 1 wherein step (b) comprises creating a multiplicity of blood flow channels within the wall of the heart.
Claim 10
Dependent Claim
34 words
The method of claim 1 wherein step (b) comprises irradiating an exterior surface of the heart with laser energy to create said at least one blood flow channel within the wall of the heart.
Claim 11
Dependent Claim
34 words
The method of claim 1 wherein step (b) comprises irradiating an interior surface of the heart with laser energy to create said at least one blood flow channel within the wall of the heart.
Claim 12
Dependent Claim
40 words
The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with laser energy delivered through a fiberoptic laser delivery device to create said at least one blood flow channel within the wall of the heart.
Claim 13
Dependent Claim
34 words
The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with infrared laser energy to create said at least one blood flow channel within the wall of the heart.
Claim 14
Dependent Claim
20 words
The method of claim 12 wherein step (b) further comprises generating said infrared laser energy with a CO 2 laser.
Claim 15
Dependent Claim
34 words
The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with near-infrared laser energy to create said at least one blood flow channel within the wall of the heart.
Claim 16
Dependent Claim
19 words
The method of claim 14 wherein step (b) further comprises generating said near-infrared laser energy with a holmium:YAG laser.
Claim 17
Dependent Claim
22 words
The method of claim 1 wherein step (c) comprises reperfusing the heart with oxygenated blood to induce the heart to resume beating.
Claim 18
Independent Claim
108 words
A method of performing transmyocardial revascularization on a heart comprising the steps of: (a) temporarily stopping the heart from beating by infusing the heart with a cardioplegic agent having a short half life to induce a brief period of asystole which has a duration of less than approximately one minute; (b) creating a multiplicity of blood flow channels within a wall of the heart by irradiating a surface of the heart with laser energy during said period of asystole, said blood flow channels having a fluid connection with a chamber of the heart; and (c) reperfusing the heart with oxygenated blood to induce the heart to resume beating.
Claim 19
Independent Claim
108 words
A method of performing transmyocardial revascularization on a heart comprising the steps of: (a) temporarily stopping the heart from beating by infusing the heart with a cardioplegic agent having a short half life to induce a brief period of asystole which has a duration of less than approximately one minute; (b) creating a multiplicity of blood flow channels within a wall of the heart by irradiating a surface of the heart with laser energy during said period of asystole, said blood flow channels having a fluid connection with a chamber of the heart; and (c) reperfusing the heart with oxygenated blood to induce the heart to resume beating.
Claim 20
Dependent Claim
29 words
The method of claim 17 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a concentration sufficient to induce asystole in the heart.
Claim 21
Dependent Claim
26 words
The method of claim 18 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a dosage of approximately 0.15-0.25 mg/kg.
Claim 22
Dependent Claim
37 words
The method of claim 17 further comprising the step of: (d) probing said blood flow channels during said period of asystole to verify the fluid connection between said blood flow channels and the chamber of the heart.
Claim 23
Dependent Claim
20 words
The method of claim 17 wherein said brief period of asystole has a duration of less than approximately twenty seconds.
Claim 24
Dependent Claim
16 words
The method of claim 18 wherein steps (a), (b) and (c) are performed without cardiopulmonary bypass.
References Cited (Backward Citations)
US4658817A
Cited
US5125926A
Cited
US5125924A
Cited
US5380316A
Cited
US5389096A
Cited
US5554152A
Cited
US5607421A
Cited
US5428039A
Cited
US5695457A
Cited
US5554497A
Cited
US5755687A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-22 | 2002-08-24 | 2003-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-22 | 2006-08-24 | 2007-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-22 | 2010-08-24 | 2011-02-23 | $7700.00 | Window Closed / Lapsed |