US5840387A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sulfonated multiblock copolymer and uses therefor
Assignee: Aegis Biosciences LLC
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Filing: 1996-06-10
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Granted: 1998-11-24
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Expires: 2016-06-10
Abstract
Abstract Sulfonated multiblock copolymers, and uses thereof, are disclosed. The sulfonated copolymers are useful for providing non-thrombogenic coatings, e.g., for medical devices, and for promoting cell growth, differentiation, or production of normal cell products. The sulfonated copolymers are also useful for administration of therapeutic agents.
Inventors
- 👤 Laurence Berlowitz-Tarrant
- 👤 Timothy N. Tangredi
- 👤 Gary E. Wnek
- 👤 Robert J. Nicolosi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:48
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/32; A61L; A61L33/00; A61L33/06; A61L33/064; Y; Y10; Y10S; Y10S623/00; Y10S623/90; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/139; Y10T428/1393; Y10T428/1397
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
41 words
A nonthrombogenic article for use in contact with blood or blood products, the ariicle comprising a substrate hanving at least one surface, said surface having disposed thereon an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 2
Dependent Claim
41 words
A nonthrombogenic article for use in contact with blood or blood products, the ariicle comprising a substrate hanving at least one surface, said surface having disposed thereon an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 3
Dependent Claim
42 words
A nonthrombogenic article for use in contact with blood or blood products, the article comprising a substrate having at least one surface, said surface having disposed thereon an anionic sulfonated styrene-ethylene/butylene-styrene triblock copolymer, wherein said triblock copolymer is at least 20% sulfonated.
Claim 4
Dependent Claim
42 words
A nonthrombogenic article for use in contact with blood or blood products, the article comprising a substrate having at least one surface, said surface having disposed thereon an anionic sulfonated styrene-ethylene/butylene-styrene triblock copolymer, wherein said triblock copolymer is at least 20% sulfonated.
Claim 5
Dependent Claim
14 words
The article of claim 2, wherein said triblock copolymer is coated on said substrate.
Claim 6
Dependent Claim
14 words
The article of claim 2, wherein said triblock copolymer is at least 35% sulfonated.
Claim 7
Dependent Claim
12 words
The article of claim 2, wherein said triblock copolymer entraps a drug.
Claim 8
Dependent Claim
14 words
The article of claim 2, wherein said triblock copolymer is grafted to said substrate.
Claim 9
Dependent Claim
27 words
The article of claim 2, wherein said article comprises a material selected from the group consisting of polytetrafluoroethylene, polyethylene tetraphthalate, titanium oxide, magnetic particles, and calcium phosphate.
Claim 10
Dependent Claim
31 words
The article of claim 2, wherein the article is selected from the group consisting of stents, catheters, cannulae, tubing, vascular grafts, artificial hearts, hear valves, pacemakers, implants, artificial joints, and prostheses.
Claim 11
Dependent Claim
12 words
The aricle of claim 2, wherein the article is an electrical lead.
Claim 12
Independent Claim
42 words
A method of manufacturing a thromboresistant article for use in contact with blood or blood products, the method comprising coaling at least one surface of an article with an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 13
Independent Claim
42 words
A method of manufacturing a thromboresistant article for use in contact with blood or blood products, the method comprising coaling at least one surface of an article with an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 14
Dependent Claim
15 words
The method of claim 10, wherein the multiblock copolymer is a sulfonated styrene-ethylene/butylene-styrene triblock copolymer.
Claim 15
Dependent Claim
14 words
The method of claim 11, wherein said triblock copolymer is at least 35% sulfonated.
Claim 16
Dependent Claim
12 words
The method of claim 11, wherein said triblock copolymer entraps a drug.
Claim 17
Dependent Claim
27 words
The method of claim 11, wherein the aricle comprises a material selected from the group consisting of polytetrafluoroethylene, polyethylene teraphtalate, titanium oxide, magnetic paticles, and calcium phosphate.
Claim 18
Dependent Claim
31 words
The method of claim 11, wherein the article is selected from the group consisting of stents, catheters, cannulae, tubing, vascular grafts, artificial hearts, heart valves, pacemakers, implants, artificial joints, and prostheses.
Claim 19
Dependent Claim
12 words
The method of claim 11, wherein the article is an electrical lead.
Claim 20
Dependent Claim
37 words
A medical implant which can be modified in situ by application of an electric field, the implant comprising a substrate having disposed thereon an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 21
Dependent Claim
37 words
A medical implant which can be modified in situ by application of an electric field, the implant comprising a substrate having disposed thereon an anionic sulfonated multiblock copolymer, wherein said multiblock copolymer is at least 20% sulfonated.
Claim 22
Dependent Claim
16 words
The medical implant of claim 17, wherein the multiblock copolymer is a sulfonated styrene-ethylene/butylene-styrene triblock copolymer.
Claim 23
Dependent Claim
13 words
The medical implant of claim 18, wherein the triblock copolymer entraps a drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-23 | 2002-05-25 | 2002-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-23 | 2006-05-25 | 2006-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-23 | 2010-05-25 | 2010-11-24 | $7700.00 | Window Closed / Lapsed |