US5837752A
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Semi-interpenetrating polymer networks
Assignee: Massachusetts Institute of Technology
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Filing: 1997-07-17
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Granted: 1998-11-17
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Expires: 2017-07-17
Abstract
Abstract Compositions for bone repair have been developed based on linear hydrophobic degradable polymers and monomers or macromers, at least one of which includes an anhydride linkage. The monomers and/or macromers crosslink each other but not to the linear polymer to form semi-interpenetrating networks. The compositions can include various excipients, therapeutic and/or diagnostic agents. The compositions can be polymerized in the presence of dissolvable particles such as inorganic salts and proteinaceous materials to provide a porous polymer network. The compositions can be injected into a patient and polymerized in situ or can be polymerized ex vivo and implanted. When polymerized ex vivo, the composition can be shaped into various articles, such as pins, screws, and hollow tubes, which can be used to repair broken bones.
Inventors
- 👤 Venkatram R. Shastri
- 👤 Robert S. Langer
- 👤 Peter J. Tarcha
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:46
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/041; A61L27/00; A61L27/14; A61L27/26; A61L27/50; A61L27/58; A61L31/14; A61L31/148; A61P; A61P19/00; C; C08; C08F; C08F283/00; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0085; Y; Y10; Y10S; Y10S525/00; Y10S525/903; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
75 words
A composition which forms a semi-interpenetrating polymer network following exposure to active species comprising a) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; and b) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
Claim 2
Dependent Claim
75 words
A composition which forms a semi-interpenetrating polymer network following exposure to active species comprising a) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; and b) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
Claim 3
Dependent Claim
15 words
The composition of claim 1 in a form suitable for repair or replacement of bone.
Claim 4
Dependent Claim
31 words
The composition of claim 1, wherein the biodegradable polymer is formed from one or more monomeric units selected from the group consisting of polyanhydrides, polyorthoesters, polyhydroxy acids, polydioxanones, polycarbonates, and polyaminocarbonates.
Claim 5
Dependent Claim
27 words
The composition of claim 1, wherein the biodegradable polymer is formed from one or more monomeric units selected from the group consisting of polyhydroxy acids and polyanhydrides.
Claim 6
Dependent Claim
13 words
The composition of claim 1, wherein the monomer or macromer is a methacrylate.
Claim 7
Dependent Claim
23 words
The composition of claim 1, wherein the monomer or macromer is polymerized, whereby the composition is in the form of a semi-interpenetrating network.
Claim 8
Dependent Claim
27 words
The composition of claim 1, further comprising an excipient selected from the group consisting of hydroxyapatite, plaster of paris, calcium carbonate, tricalcium phosphate, polyphosphates, polyphosphonates and polyphosphites.
Claim 9
Dependent Claim
26 words
The composition of claim 1 wherein the covalently crosslinkable monomer or macromer is present in a weight percentage of between 30 and 70 percent by weight.
Claim 10
Dependent Claim
23 words
The composition of claim 1 wherein the linear polymer is present in a weight percentage of between 10 and 90 percent by weight.
Claim 11
Dependent Claim
14 words
The composition of claim 1, further comprising one or more diagnostic or therapeutic agents.
Claim 12
Dependent Claim
16 words
The composition of claim 10, wherein the diagnostic or therapeutic agents are incorporated into a microparticle.
Claim 13
Dependent Claim
24 words
The composition of claim 1, further comprising one or more porosity forming agents selected from the group consisting of inorganic salts and proteinaceous materials.
Claim 14
Independent Claim
80 words
A method for repairing or regenerating bone or creating solid prosthetic articles in situ comprising: a) injecting into a patient a composition comprising i) a linear polymer selected from the group consisting of linear hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage; b) forming a semi-interpenetrating network upon exposure to active species.
Claim 15
Independent Claim
80 words
A method for repairing or regenerating bone or creating solid prosthetic articles in situ comprising: a) injecting into a patient a composition comprising i) a linear polymer selected from the group consisting of linear hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage; b) forming a semi-interpenetrating network upon exposure to active species.
Claim 16
Dependent Claim
30 words
The method of claim 13 wherein the polymer is formed from one or more monomeric units selected from the group consisting of polyanhydrides, polyorthoesters, polyhydroxy acids, polydioxanones, polycarbonates, and polyaminocarbonates.
Claim 17
Dependent Claim
26 words
The method of claim 13 wherein the polymer is formed from one or more monomeric units selected from the group consisting of polyhydroxy acids and polyanhydrides.
Claim 18
Dependent Claim
13 words
The method of claim 13 wherein the monomer or macromer is a (meth)acrylate.
Claim 19
Dependent Claim
30 words
The method of claim 13 wherein the composition further comprises an excipient selected from the group consisting of hydroxyapatite, plaster of paris, calcium carbonate, tricalcium phosphate, polyphosphates, polyphosphonates and polyphosphites.
Claim 20
Dependent Claim
26 words
The method of claim 13 wherein the covalently crosslinkable monomer or macromer is present in a weight percentage of between 30 and 70 percent by weight.
Claim 21
Dependent Claim
23 words
The method of claim 13 wherein the linear polymer is present in a weight percentage of between 10 and 90 percent by weight.
Claim 22
Dependent Claim
17 words
The method of claim 13 wherein the composition further comprises one or more diagnostic or therapeutic agents.
Claim 23
Dependent Claim
16 words
The method of claim 20 wherein the diagnostic or therapeutic agents are incorporated into a microparticle.
Claim 24
Dependent Claim
26 words
The method of claim 13 wherein the composition further comprises one or more porosity forming agents selected from the group consisting inorganic salts and proteinaceous materials.
Claim 25
Independent Claim
82 words
A method for preparing solid articles for use in repairing or regenerating bone comprising a) casting or injecting into a suitable mold a composition comprising i) a linear polymer selected from the group consisting of linear hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage; b) forming a semi-interpenetrating network upon exposure to active species.
Claim 26
Independent Claim
82 words
A method for preparing solid articles for use in repairing or regenerating bone comprising a) casting or injecting into a suitable mold a composition comprising i) a linear polymer selected from the group consisting of linear hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers; ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage; b) forming a semi-interpenetrating network upon exposure to active species.
Claim 27
Dependent Claim
30 words
The method of claim 23 wherein the polymer is formed from one or more monomeric units selected from the group consisting of polyanhydrides, polyorthoesters, polyhydroxy acids, polydioxanones, polycarbonates, and polyaminocarbonates.
Claim 28
Dependent Claim
26 words
The method of claim 23 wherein the polymer is formed from one or more monomeric units selected from the group consisting of polyhydroxy acids and polyanhydrides.
Claim 29
Dependent Claim
13 words
The method of claim 23 wherein the monomer or macromer is a (meth)acrylate.
Claim 30
Dependent Claim
30 words
The method of claim 23 wherein the composition further comprises an excipient selected from the group consisting of hydroxyapatite, plaster of paris, calcium carbonate, tricalcium phosphate, polyphosphates, polyphosphonates and polyphosphites.
Claim 31
Dependent Claim
26 words
The method of claim 23 wherein the covalently crosslinkable monomer or macromer is present in a weight percentage of between 30 and 70 percent by weight.
Claim 32
Dependent Claim
23 words
The method of claim 23 wherein the linear polymer is present in a weight percentage of between 10 and 90 percent by weight.
Claim 33
Dependent Claim
17 words
The method of claim 23 wherein the composition further comprises one or more diagnostic or therapeutic agents.
Claim 34
Dependent Claim
16 words
The method of claim 30 wherein the diagnostic or therapeutic agents are incorporated into a microparticle.
Claim 35
Dependent Claim
26 words
The method of claim 23 wherein the composition further comprises one or more porosity forming agents selected from the group consisting inorganic salts and proteinaceous materials.
References Cited (Backward Citations)
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