US5810806A — Methods and devices for collection of soft tissue

Claim 1

Independent Claim 93 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a distal end, a proximal end, and a longitudinal axis; and an electrosurgical cutting element disposed at the distal end of the tubular body, said cutting element being movable, relative to said tubular body, in a direction transverse to said axis, across a cross-sectional area defined by the distal end of said tubular body, in order to sever a distal end of an intact tissue sample core captured within said primary lumen.

Claim 2

Dependent Claim 93 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a distal end, a proximal end, and a longitudinal axis; and an electrosurgical cutting element disposed at the distal end of the tubular body, said cutting element being movable, relative to said tubular body, in a direction transverse to said axis, across a cross-sectional area defined by the distal end of said tubular body, in order to sever a distal end of an intact tissue sample core captured within said primary lumen.

Claim 3

Dependent Claim 27 words

The tissue sampling apparatus as recited in claim 1, wherein the electrosurgical cutting element comprises a wire disposed distally of the distal end of the tubular body.

Claim 4

Dependent Claim 41 words

The tissue sampling apparatus as recited in claim 2, wherein said wire comprises a single substantially circular wire which is pivotable from side-to-side to sever a distal end of the tissue sample, thereby completely severing the tissue sample from surrounding tissue.

Claim 5

Dependent Claim 86 words

The tissue sampling apparatus as recited in claim 2, wherein the wire comprises a pair of wires which together are actuatable from a rest position to a severing position, the pair of wires together forming a substantially circular cutting element disposed circumferentially along a distal edge of the tubular body in said rest position, and the pair of wires being drawn together across the cross-sectional area in order to sever a distal end of the tissue sample, thereby completely severing the tissue sample from surrounding tissue.

Claim 6

Dependent Claim 103 words

The tissue sampling apparatus as recited in claim 2, wherein the wire comprises a single wire which is actuatable from a rest position to a severing position, the wire forming a substantially circular cutting element disposed circumferentially about a distal edge of the tubular body in the rest position, and the wire being drawn across the cross-sectional area of the distal end of the tubular body while being electrically energized in the severing position, the drawing motion of the wire across the cross-sectional area functioning to sever a distal end of the tissue sample, thereby completely severing the tissue sample from surrounding tissue.

Claim 7

Dependent Claim 99 words

The tissue sampling apparatus as recited in claim 2, wherein the wire comprises a single wire which is actuatable from a rest position to a severing position, the wire forming a semicircular cutting element disposed circumferentially along a portion of a distal edge of the tubular body in the rest position, and the wire being drawn across the cross-sectional area of the distal end of the tubular body while being electrically energized in the severing position, the drawing motion of the wire across the cross-sectional area functioning to sever a portion of the distal end of the tissue sample.

Claim 8

Dependent Claim 92 words

The tissue sampling apparatus as recited in claim 2, wherein the distal end of the tubular body comprises a second electrosurgical cutting element, the tubular body being constructed of an electrically conductive material and being further surrounded by an insulative jacket along its entire length except at its distal cutting end, the second electrosurgical cutting element being adapted to cut tissue, creating a tissue sample core, as the apparatus is advanced into a patient's body, and the electrosurgical cutting wire being adapted to sever a distal end of said tissue sample core.

Claim 9

Dependent Claim 38 words

The tissue sampling apparatus as recited in claim 2, and further comprising a support stem attached to said wire and disposed proximally thereof for supporting and controlling said wire, and a secondary lumen for receiving said support stem.

Claim 10

Dependent Claim 40 words

The tissue sampling apparatus as recited in claim 8, wherein the support stem is movable proximally to retract the wire cutting element in a proximal direction, and is movable distally to extend the wire cutting element in a distal direction.

Claim 11

Dependent Claim 32 words

The tissue sampling apparatus as recited in claim 9, wherein the support stem is preformed to allow movement of the wire cutting element in a non-linear direction as it is extended distally.

Claim 12

Dependent Claim 25 words

The tissue sampling apparatus as recited in claim 8, and further comprising a mechanical actuator for moving said support stem to thereby actuate said wire.

Claim 13

Dependent Claim 23 words

The tissue sampling apparatus as recited in claim 1, wherein the electrosurgical cutting element is also movable axially relative to said tubular body.

Claim 14

Dependent Claim 27 words

The tissue sampling apparatus as recited in claim 1, wherein the tissue sample core has a diameter substantially equal to an inside diameter of said tubular body.

Claim 15

Dependent Claim 23 words

The tissue sampling apparatus as recited in claim 1, and further comprising means for drawing tissue to be sampled into the primary lumen.

Claim 16

Dependent Claim 35 words

The tissue sampling apparatus as recited in claim 14, wherein said means for drawing tissue comprises a mechanical grasper having openable jaws which are adapted to extend through the primary lumen of said tubular body.

Claim 17

Dependent Claim 29 words

The tissue sampling apparatus as recited in claim 14, wherein said means for drawing tissue comprises a source of vacuum pressure for drawing a vacuum through the primary lumen.

Claim 18

Dependent Claim 97 words

The tissue sampling apparatus as recited in claim 16, and further comprising: a support stem attached to said wire and disposed proximally thereof for supporting and controlling said wire; a secondary lumen for receiving said support stem; and an annular space surrounding said support stem within said secondary lumen, said annular space functioning as a vent port, drawing air at ambient pressure distally therethrough to repressurize regions in said primary lumen distal to the tissue sample being drawn proximally through said primary lumen, said repressurization functioning to assist transport of said sample proximally through the primary lumen.

Claim 19

Dependent Claim 83 words

The tissue sampling apparatus as recited in claim 16, wherein said body lumen is adapted to accommodate a plurality of tissue samples, said apparatus further comprising a movable stop plunger disposed at the proximal end of the tubular body lumen, said movable stop plunger preventing the tissue samples from being drawn proximally to the vacuum pressure source, and being movable in a proximal direction as additional tissue samples are captured in order to expand the lumen space available to accommodate the tissue samples.

Claim 20

Dependent Claim 66 words

The tissue sampling apparatus as recited in claim 16, wherein said apparatus further comprises a housing portion, the housing portion comprising a first switch for simultaneously activating the source of vacuum pressure and an electrocautery generator for providing electrical current to said electrosurgical cutting element, a second switch for activating only the source of vacuum pressure, and a third switch for activating only the electrocautery generator.

Claim 21

Dependent Claim 21 words

The tissue sampling apparatus as recited in claim 16, and further comprising a tissue reservoir disposed proximally of said tubular body.

Claim 22

Dependent Claim 30 words

The tissue sampling apparatus as recited in claim 20, wherein said tissue reservoir is disposed in a vacuum pressure line between the tubular body and the source of vacuum pressure.

Claim 23

Dependent Claim 25 words

The tissue sampling apparatus as recited in claim 16, and further comprising a vacuum override switch for selectively cutting off the source of vacuum pressure.

Claim 24

Dependent Claim 20 words

The tissue sampling apparatus as recited in claim 1, wherein the tubular body is comprised of a non-electrically conductive material.

Claim 25

Dependent Claim 23 words

The tissue sampling apparatus as recited in claim 1, wherein said tubular body lumen is adapted to accommodate a plurality of tissue samples.

Claim 26

Dependent Claim 30 words

The tissue sampling apparatus as recited in claim 1, wherein said apparatus is adapted to enter solid tissue, thereby creating a blind hole as it is advanced into said tissue.

Claim 27

Dependent Claim 47 words

The tissue sampling apparatus as recited in claim 1, wherein the tubular body is flexible and steerable in order to obtain tissue samples from any desired location on the wall of a tissue cavity, and the apparatus is adapted for delivery to a desired tissue location percutaneously.

Claim 28

Dependent Claim 63 words

The tissue sampling apparatus as recited in claim 26, and further comprising a percutaneous biopsy instrument having a hollow outer piercing needle which is adapted for entry into a patient's body, the hollow outer piercing needle including a lumen extending along its length, wherein the flexible tubular body is adapted for insertion into the patient's body through said hollow outer piercing needle lumen.

Claim 29

Dependent Claim 29 words

The tissue sampling apparatus as recited in claim 1, and further comprising a coating on the interior surface of the tubular body to facilitate transport of tissue samples therethrough.

Claim 30

Dependent Claim 28 words

The tissue sampling apparatus as recited in claim 1, and further comprising depth marks on said tubular body to facilitate positioning of the apparatus in a patient's body.

Claim 31

Dependent Claim 27 words

The tissue sampling apparatus as recited in claim 1, wherein said tubular body is adapted to accommodate insertion of a sensing probe through the primary lumen thereof.

Claim 32

Dependent Claim 18 words

The tissue sampling apparatus as recited in claim 30, wherein said sensing probe comprises a radiation detecting probe.

Claim 33

Dependent Claim 17 words

The tissue sampling apparatus as recited in claim 30, wherein said sensing probe comprises an ultrasound probe.

Claim 34

Dependent Claim 17 words

The tissue sampling apparatus as recited in claim 30, wherein said sensing probe comprises a multivision probe.

Claim 35

Dependent Claim 46 words

The tissue sampling apparatus as recited in claim 30, wherein said apparatus is adapted to accommodate a scissors through the primary lumen after the sensing probe has been removed therefrom, said scissors functioning to dissect distally to a position just proximal to a lesion of interest.

Claim 36

Dependent Claim 204 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a distal end, a proximal end, and a longitudinal axis; an electrosurgical wire disposed at the distal end of the tubular body, said wire comprising a single wire loop which is actuatable from a rest position to a severing position, the wire loop forming a semicircular cutting element disposed along a circumferential portion of the distal end of the tubular body in the rest position, and the wire being movable across a cross-sectional area of the distal end of the tubular body while being electrically energized, from the rest position to the severing position, wherein said wire lies along a circumferential portion of the distal end of the tubular body which is opposed to the circumferential portion along which the wire is disposed in the rest position, the wire having a pair of ends which are each fixedly attached to opposing sides of the tubular body distal end, the transverse movement of the wire across said cross-sectional area of the distal end of the tube from the rest position to the severing position functioning to sever a distal end of the tissue sample.

Claim 37

Dependent Claim 204 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a distal end, a proximal end, and a longitudinal axis; an electrosurgical wire disposed at the distal end of the tubular body, said wire comprising a single wire loop which is actuatable from a rest position to a severing position, the wire loop forming a semicircular cutting element disposed along a circumferential portion of the distal end of the tubular body in the rest position, and the wire being movable across a cross-sectional area of the distal end of the tubular body while being electrically energized, from the rest position to the severing position, wherein said wire lies along a circumferential portion of the distal end of the tubular body which is opposed to the circumferential portion along which the wire is disposed in the rest position, the wire having a pair of ends which are each fixedly attached to opposing sides of the tubular body distal end, the transverse movement of the wire across said cross-sectional area of the distal end of the tube from the rest position to the severing position functioning to sever a distal end of the tissue sample.

Claim 38

Dependent Claim 198 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a wall, distal end, a proximal end, and a longitudinal axis; a slit extending part of the way through the thickness of the tube wall, the slit creating a flexible band of material between the slit and the distal end of the tubular body, the flexible band of material being predisposed to rest in a partially collapsed position across the cross-sectional area of the tubular body; an inner coaxial tube insertable into the lumen of the tubular body to thereby push the material band into a circumferential configuration substantially coincident with the remainder of the tubular body, the tubular body being electrically conductive to conduct electrical energy from an electrocautery generator to the flexible band of material; said flexible band of material comprising an electrosurgical element, wherein when the inner coaxial tube is removed from the tubular body lumen, the electrically energized flexible band of material collapses to its rest position across the cross-sectional area of the tubular body, the collapsing motion of the band of material functioning to sever the distal end of a tissue sample.

Claim 39

Dependent Claim 198 words

A tissue sampling apparatus, comprising: a tubular body having a primary lumen for receiving a tissue sample, the tubular body having a wall, distal end, a proximal end, and a longitudinal axis; a slit extending part of the way through the thickness of the tube wall, the slit creating a flexible band of material between the slit and the distal end of the tubular body, the flexible band of material being predisposed to rest in a partially collapsed position across the cross-sectional area of the tubular body; an inner coaxial tube insertable into the lumen of the tubular body to thereby push the material band into a circumferential configuration substantially coincident with the remainder of the tubular body, the tubular body being electrically conductive to conduct electrical energy from an electrocautery generator to the flexible band of material; said flexible band of material comprising an electrosurgical element, wherein when the inner coaxial tube is removed from the tubular body lumen, the electrically energized flexible band of material collapses to its rest position across the cross-sectional area of the tubular body, the collapsing motion of the band of material functioning to sever the distal end of a tissue sample.

Claim 40

Independent Claim 173 words

A method of capturing a body tissue sample using a tissue sampling apparatus comprising a tubular body having a lumen extending therethrough, a distal end, at least one electrosurgical cutting element disposed distally of the distal end of the tubular body, an actuator for moving the at least one cutting element, and an electrocautery generator, the method comprising: activating the electrocautery generator to energize the at least one electrosurgical cutting element; advancing the tubular body through a solid tissue portion a desired distance so that one of the at least one energized electrosurgical cutting elements cuts a tissue sample core as the tissue sample enters the lumen, the cutting process creating a blind hole in said solid tissue portion; and actuating one of the at least one electrosurgical cutting elements so that it moves across at least a portion of a cross-sectional area of the tissue sample core at its distal end, thereby severing the distal end to capture the tissue sample core in a substantially intact condition within the tubular body lumen.

Claim 41

Independent Claim 173 words

A method of capturing a body tissue sample using a tissue sampling apparatus comprising a tubular body having a lumen extending therethrough, a distal end, at least one electrosurgical cutting element disposed distally of the distal end of the tubular body, an actuator for moving the at least one cutting element, and an electrocautery generator, the method comprising: activating the electrocautery generator to energize the at least one electrosurgical cutting element; advancing the tubular body through a solid tissue portion a desired distance so that one of the at least one energized electrosurgical cutting elements cuts a tissue sample core as the tissue sample enters the lumen, the cutting process creating a blind hole in said solid tissue portion; and actuating one of the at least one electrosurgical cutting elements so that it moves across at least a portion of a cross-sectional area of the tissue sample core at its distal end, thereby severing the distal end to capture the tissue sample core in a substantially intact condition within the tubular body lumen.

Claim 42

Dependent Claim 31 words

The method of capturing a body tissue sample as recited in claim 37, wherein the tissue sample core has a diameter substantially equal to an inner diameter of the tubular body.

Claim 43

Dependent Claim 28 words

The method of capturing a body tissue sample as recited in claim 37, wherein the at least one electrosurgical cutting element comprises only a single electrosurgical cutting element.

Claim 44

Dependent Claim 62 words

The method of capturing a body tissue sample as recited in claim 37, wherein the at least one electrosurgical cutting element comprises first and second electrosurgical cutting elements, the first electrosurgical cutting element cut ting said tissue sample core during the advancing step, and the second electrosurgical cutting element severing a distal end of the tissue sample core during the actuating step.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2001-09-21	2002-03-23	2002-09-22	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2005-09-21	2006-03-23	2006-09-22	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2009-09-21	2010-03-23	2010-09-22	$7700.00	Window Closed / Lapsed

Methods and devices for collection of soft tissue

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