US5776174A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilization of vascular lesions by ultraviolet radiation
Assignee: Illumenex Corp
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Filing: 1995-01-30
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Granted: 1998-07-07
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Expires: 2015-01-30
Abstract
Abstract Ultraviolet radiation can be used to treat vascular diseases. In particular, for unstable lesions where angioplasty may not be warranted, cytotoxic, nonablative ultraviolet radiation, preferably at a wavelength in the range of about 240 to about 280 nanometers, can be used to disable the intima and reduce spasms associated with partially occluded blood vessels.
Inventors
- 👤 Robert A. Van Tassel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:05
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0601
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
76 words
A method of treating an unstable atherosclerotic lesion comprising: disposing an optical waveguide means inside a blood vessel; locating the waveguide means adjacent to an atherosclerotic lesion site within the vessel; and irradiating the lesion site with non-ablative, cytotoxic UV radiation having a wavelength ranging from about 240-280 nanometers via said optical waveguide means to inactivate smooth muscle cells in the vicinity of the lesion site without the use of either angioplasty or a photoactivatable psoralen.
Claim 2
Independent Claim
76 words
A method of treating an unstable atherosclerotic lesion comprising: disposing an optical waveguide means inside a blood vessel; locating the waveguide means adjacent to an atherosclerotic lesion site within the vessel; and irradiating the lesion site with non-ablative, cytotoxic UV radiation having a wavelength ranging from about 240-280 nanometers via said optical waveguide means to inactivate smooth muscle cells in the vicinity of the lesion site without the use of either angioplasty or a photoactivatable psoralen.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the step of irradiating the lesion site further serves to reduce the migration of smooth muscle cells.
Claim 4
Independent Claim
14 words
The method of claim I wherein the UV radiation is low power UV radiation.
Claim 5
Dependent Claim
21 words
The method of claim 1 wherein the UV radiation has power density of about 5 watts per square centimeter or less.
Claim 6
Dependent Claim
26 words
The method of claim 1 wherein the total dose of UV radiation administered to the lesion site is about 1000 Joules per square centimeter or less.
Claim 7
Dependent Claim
24 words
The method of claim 1 wherein the UV radiation is pulsed UV radiation having an energy of about 5 millijoules per pulse or less.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-07-06 | 2002-01-05 | 2002-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-06 | 2006-01-05 | 2006-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-06 | 2010-01-05 | 2010-07-07 | $7700.00 | Window Closed / Lapsed |