US5741514A
Expired / Lapsed
US
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Method for reducing serum lipoprotein(a) concentration
Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1995-08-31
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Granted: 1998-04-21
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Expires: 2015-08-31
Abstract
Abstract A method of reducing the serum Lp(a) concentration in a subject is disclosed. A suspension of small, unilamellar vesicles composed primarily of phospholipids, similar in nature to those of egg phosphatidylcholine, is administered parenterally to a subject having or at risk for developing a disease condition associated with an elevated serum Lp(a) concentration. In the method, liposomes are infused over an extended period of time of at least several weeks, until a significant drop in serum Lp(a) concentration is observed.
Inventors
- 👤 Yechezkel Barenholz
- 👤 Hilary Shmeeda
- 👤 Tova Chajek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:36
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685; A61K38/00; A61K38/16; A61K38/17; A61K38/1703; A61K38/1709; A61K9/00; A61K9/10; A61K9/127; A61K9/1275; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/788; Y10S977/797; Y10S977/798; Y10S977/799; Y10S977/801; Y10S977/902; Y10S977/904; Y10S977/906; Y10S977/907; Y10S977/915
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
100 words
A method of inhibiting restenosis in a subject following percutaneous transluminal coronary angioplasty or surgical resection of vascular tissue, comprising determining a pretreatment serum Lp(a) concentration of the subject, intravenously administering to the subject a suspension of small unilammellar liposomes composed primarily of phosphatidylcholines having phase transition temperatures in the range between about -10° and 37° C., and repeating said administering over a period of at least about two weeks, and in an amount effective to produce a reduction in serum Lp(a) concentration in the subject of at least 20% relative to the pretreatment serum Lp(a) concentration of the subject.
Claim 2
Independent Claim
100 words
A method of inhibiting restenosis in a subject following percutaneous transluminal coronary angioplasty or surgical resection of vascular tissue, comprising determining a pretreatment serum Lp(a) concentration of the subject, intravenously administering to the subject a suspension of small unilammellar liposomes composed primarily of phosphatidylcholines having phase transition temperatures in the range between about -10° and 37° C., and repeating said administering over a period of at least about two weeks, and in an amount effective to produce a reduction in serum Lp(a) concentration in the subject of at least 20% relative to the pretreatment serum Lp(a) concentration of the subject.
Claim 3
Dependent Claim
19 words
The method of claim 1, in which the subject is determined to have an elevated pretreatment serum Lp(a) concentration.
Claim 4
Dependent Claim
18 words
The method of claim 2, wherein said liposomes range in size from about 0.02 to about 0.12 microns.
Claim 5
Dependent Claim
11 words
The method of claim 2, wherein said phosphatidylcholines are egg phosphatidylcholines.
Claim 6
Dependent Claim
17 words
The method of claim 2, wherein said phosphatidylcholines have phase transition temperatures less than about 5° C.
Claim 7
Dependent Claim
31 words
The method of claim 2, wherein said liposome suspension is administered at least one time per week and at a dose in the range of about 50-1,000 mg lipid/kg body weight.
Claim 8
Dependent Claim
18 words
The method of claim 2, wherein the method is practiced on the subject following percutaneous transluminal coronary angioplasty.
Claim 9
Dependent Claim
19 words
The method of claim 2, wherein the method is practiced on the subject following surgical resection of vascular tissue.
Claim 10
Independent Claim
122 words
A method of inhibiting restenosis in a subject having an elevated pretreatment serum Lp(a) concentration following percutaneous transluminal coronary angioplasty or surgical reaction of vascular tissue, comprising intravenously administering to the subject a suspension of small unilamellar liposomes consisting essentially of phosphatidylcholines having phase transition temperatures in the range between about -10° and 37° C., and repeating the administering of the liposomes over a period of at least about two weeks at least one time per week at a dose in the range of about 50-1,000 mg lipid/kg body weight of the subject in a manner effective to produce a reduction in serum Lp(a) concentration in the subject of at least 20% relative to the protreatment serum Lp(a) concentration of the subject.
Claim 11
Independent Claim
122 words
A method of inhibiting restenosis in a subject having an elevated pretreatment serum Lp(a) concentration following percutaneous transluminal coronary angioplasty or surgical reaction of vascular tissue, comprising intravenously administering to the subject a suspension of small unilamellar liposomes consisting essentially of phosphatidylcholines having phase transition temperatures in the range between about -10° and 37° C., and repeating the administering of the liposomes over a period of at least about two weeks at least one time per week at a dose in the range of about 50-1,000 mg lipid/kg body weight of the subject in a manner effective to produce a reduction in serum Lp(a) concentration in the subject of at least 20% relative to the protreatment serum Lp(a) concentration of the subject.
Claim 12
Dependent Claim
18 words
The method of claim 9, wherein said liposomes range in size from about 0.02 to about 0.12 microns.
Claim 13
Dependent Claim
12 words
The method of claim 10, wherein the said phosphatidylcholines are egg phosphatidylcholines.
Claim 14
Dependent Claim
17 words
The method of claim 11, wherein said phosphatidylcholines have phase transition temperatures less than about 5° C.
Claim 15
Dependent Claim
18 words
The method of claim 12, wherein the method is practiced on the subject following percutaneous transluminal coronary angioplasty.
Claim 16
Dependent Claim
19 words
The method of claim 12, wherein the method is practiced on the subject following surgical resection of vascular tissue.
References Cited (Backward Citations)
US4812314A
Cited
US5489611A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-20 | 2001-10-20 | 2002-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-20 | 2005-10-20 | 2006-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-20 | 2009-10-20 | 2010-04-21 | $7700.00 | Window Closed / Lapsed |