Patent FR1059749A successfully refreshed from Google Patents.
US5735863A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration
Assignee: Fidia SpA
•
Filing: 1992-02-10
•
Granted: 1998-04-07
•
Expires: 2012-02-10
Abstract
Abstract The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded in a matrix and coextruded with active factors wherein both the matrix and the threads are comprised of biocompatible and bioabsorbable esters of hyaluronic acid.
Inventors
- 👤 Francesco Della Valle
- 👤 Aurelio Romeo
- 👤 Lanfranco Callegaro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:24
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61L31/04; A61L31/042; A61L31/12; A61L31/125; A61L31/129; A61B; A61B17/00; A61B17/11; A61B17/1128; A61F; A61F2/00; A61F2/0077; A61F2/02; A61F2/04; A61F2210/00; A61F2210/0004; A61L2430/00; A61L2430/32
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
76 words
A medical device for use in the treatment of damaged nerve tissue, said device comprising a tubular, biocompatible and bioabsorbable composite of at least two layers of coiled threads which comprises: a matrix comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid; a thread embedded in said matrix, said thread being comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid; and an active factor, said factor having activity for treatment of damaged nerve tissue.
Claim 2
Dependent Claim
76 words
A medical device for use in the treatment of damaged nerve tissue, said device comprising a tubular, biocompatible and bioabsorbable composite of at least two layers of coiled threads which comprises: a matrix comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid; a thread embedded in said matrix, said thread being comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid; and an active factor, said factor having activity for treatment of damaged nerve tissue.
Claim 3
Dependent Claim
27 words
A medical device according to claim 1, wherein said ester of hyaluronic acid is a total or partial ester of hyaluronic acid with a pharmacologically inactive alcohol.
Claim 4
Dependent Claim
18 words
A medical device according to claim 2, wherein said alcohol is an aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohol.
Claim 5
Dependent Claim
17 words
A medical device according to claim 3, wherein said aliphatic alcohol is a C 1-12 aliphatic alcohol.
Claim 6
Dependent Claim
17 words
A medical device according to claim 2, wherein said ester is a total ester of hyaluronic acid.
Claim 7
Dependent Claim
17 words
A medical device according to claim 2, wherein said ester is a partial ester of hyaluronic acid.
Claim 8
Dependent Claim
14 words
A medical device according to claim 2, wherein said aliphatic alcohol is benzyl alcohol.
Claim 9
Dependent Claim
24 words
A medical device according to claim 1, wherein said ester of hyaluronic acid is an ester of hyaluronic acid 75% esterified with benzyl alcohol.
Claim 10
Dependent Claim
37 words
A medical device according claim 1, wherein said active factor is a member selected from the group consisting of nerve growth factor, ciliary neuronotrophic factor, brain derived neurotrophic factor, neurotropin-3, gangliosides, derivatives of gangliosides, and mixtures thereof.
Claim 11
Dependent Claim
21 words
A method of making a medical device according to claim 9, comprising coextruding said active factor and thread in said matrix.
Claim 12
Dependent Claim
32 words
A medical device according to claim 1, wherein said device has a minimum value of 150 denier, a minimum tensile strength at break of 0.4 gr/denier and a minimum elongation of 2%.
Claim 13
Dependent Claim
19 words
A medical device according to claim 1, wherein said device has a weight of about 4 to 25 mg/cm.
Claim 14
Dependent Claim
19 words
A medical device according to claim 1, wherein said device has a thickness of between 80 and 1000 μm.
Claim 15
Dependent Claim
23 words
A medical device according to claim 1, wherein the density of the coiled thread is at least 3 coils per cm 2 .
Claim 16
Dependent Claim
19 words
A method of treating a damaged nerve comprising securing said damaged nerve in a medical device of claim 1.
Claim 17
Dependent Claim
26 words
The method according to claim 15, wherein said medical device is comprised of a total or partial ester of hyaluronic acid with a pharmacologically inactive alcohol.
Claim 18
Dependent Claim
15 words
The method according to claim 16, wherein said alcohol is a C 1-12 aliphatic alcohol.
Claim 19
Dependent Claim
12 words
The method according to claim 16, wherein said alcohol is benzyl alcohol.
Claim 20
Dependent Claim
48 words
A process for the preparation of a medical device which comprises winding a thread embedded in a matrix by means of a rotating cylindrical template operatively connected to a thread distributor, wherein said thread and said matrix are comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid.
Claim 21
Dependent Claim
48 words
A process for the preparation of a medical device which comprises winding a thread embedded in a matrix by means of a rotating cylindrical template operatively connected to a thread distributor, wherein said thread and said matrix are comprised of a biocompatible, bioabsorbable, water-insoluble ester of hyaluronic acid.
References Cited (Backward Citations)
US4534349A
Cited
US4851521A
Cited
WO1988006871A1
Cited
WO1989000431A1
Cited
US5147399A
Cited
WO1990005522A1
Cited
WO1990005552A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-06 | 2001-10-06 | 2002-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-06 | 2005-10-06 | 2006-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-06 | 2009-10-06 | 2010-04-07 | $7700.00 | Window Closed / Lapsed |