US5728752A
Expired / Lapsed
US
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Injectable microdipersions for soft tissue repair and augmentation
Assignee: Ethicon Inc
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Filing: 1996-03-15
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Granted: 1998-03-17
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Expires: 2016-03-15
Abstract
Abstract The present invention provides injectable, bioabsorbable microdispersions suitable for use as a soft tissue repair or augmentation material in animals comprising a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers of a plurality of at least two different first lactone repeating units and other liquid polymers; and a particulate material. Additionally, the present invention also discloses methods of using these microdispersions for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.
Inventors
- 👤 Angelo G. Scopelianos
- 👤 Steven C. Arnold
- 👤 Rao S. Bezwada
- 👤 Mark B. Roller
- 👤 Shawn T. Huxel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L27/00; A61L27/14; A61L27/18
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
233 words
A method for repairing or augmenting soft tissue in animals comprising the steps of: selecting the animal soft tissue to be repaired or augmented and placing a fluid, injectable, bioabsorbable microdispersion suitable for use as a soft tissue repair or augmentation material composed of a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers composed of a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units; wherein the first lactone repeating units are selected from the group consisting of ε-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, p-dioxanone repeating units and combinations thereof; and a particulate material that is selected from the group consisting of solid homopolymers of poly(ε-caprolactone), solid homopolymers of poly(p-dioxanone), solid homopolymers of poly(trimethylene carbonate), solid copolymers of a plurality of ε-caprolactone repeating units and third lactone repeating units, solid copolymers of a plurality of trimethylene carbonate repeating units and second lactone repeating unit; wherein the third lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, trimethylene carbonate repeating units, p-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1-5-dioxepan-2-one repeating units and combinations thereof into the animal soft tissue.
Claim 2
Independent Claim
233 words
A method for repairing or augmenting soft tissue in animals comprising the steps of: selecting the animal soft tissue to be repaired or augmented and placing a fluid, injectable, bioabsorbable microdispersion suitable for use as a soft tissue repair or augmentation material composed of a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers composed of a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units; wherein the first lactone repeating units are selected from the group consisting of ε-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, p-dioxanone repeating units and combinations thereof; and a particulate material that is selected from the group consisting of solid homopolymers of poly(ε-caprolactone), solid homopolymers of poly(p-dioxanone), solid homopolymers of poly(trimethylene carbonate), solid copolymers of a plurality of ε-caprolactone repeating units and third lactone repeating units, solid copolymers of a plurality of trimethylene carbonate repeating units and second lactone repeating unit; wherein the third lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, trimethylene carbonate repeating units, p-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1-5-dioxepan-2-one repeating units and combinations thereof into the animal soft tissue.
Claim 3
Dependent Claim
121 words
The method of claim 1 wherein the fluid carrier is a liquid polymer selected from the group consisting of polymers of from about 65 mole percent to about 35 mole percent of ε-caprolactone repeating units with the remainder being the first or second lactone group of repeating units, polymers of from about 65 to about 35 mole percent of ether lactone repeating units with the remainder being second lactone group of repeating units, polymers of from about 65 to about 35 mole percent of trimethylene carbonate repeating units with the remainder being second lactone group of repeating units, and polymers of from about 65 to about 35 mole percent ether lactone repeating units with the remainder being trimethylene carbonate repeating units.
Claim 4
Dependent Claim
39 words
The method of claim 1 wherein the particulate material is a solid polymer of ε-caprolactone repeating units and the third lactone group of repeating units and contains from about 100 to about 70 mole percent of ε-caprolactone repeating units.
Claim 5
Dependent Claim
37 words
The method claim 1 wherein the particulate material is a solid polymer of trimethylene carbonate repeating units and the second lactone repeating units and contains from about 1 to about 20 mole percent trimethylene carbonate repeating units.
Claim 6
Dependent Claim
33 words
The method of claim 1 wherein the fluid carrier used is a liquid polymer selected from the group consisting of poly(ε-caprolactone-co-trimethylene carbonate), poly(lactide-co-trimethylene carbonate) poly(ε-caprolactone-co-p-dioxanone), poly(trimethylene carbonate-co-p-dioxanone), poly(ε-caprolactone-co-lactide), poly(lactide-co-1,4-dioxepan-2-one), poly(1,4-dioxepan-2-one-co-p-dioxanone), poly(lactide-co-1,5-dioxepan-2-one), and poly(1,5-dioxepan-2-one-co-p-dioxanone).
Claim 7
Dependent Claim
43 words
The method of claim 1 wherein the particulate material used in the method is a copolymer of ε-caprolactone repeating units and the third lactone repeating units and contains in the range of from about 95 to about 85 mole percent ε-caprolactone repeating units.
Claim 8
Dependent Claim
35 words
The method of claim 1 wherein the weight percent of fluid carrier in the microdispersion is in the range of from about 20 to about 99 weight percent with the remainder being the particulate material.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein the animal soft tissue selected is the skin.
Claim 10
Dependent Claim
18 words
The method of claim 8 wherein the microdispersion is injected into facial soft tissue to provide facial contouring.
Claim 11
Dependent Claim
15 words
The method of claim 1 wherein the animal soft tissue selected is a sphincter muscle.
Claim 12
Dependent Claim
15 words
The method of claim 1 wherein the animal soft tissue selected is the urinary bladder.
Claim 13
Dependent Claim
23 words
The method of claim 1 wherein the animal is selected from the group consisting of humans, dogs, cats, cattle sheep, horses and primates.
Claim 14
Dependent Claim
10 words
The method of claim 1 wherein the animal is human.
Claim 15
Dependent Claim
10 words
The method of claim 8 wherein the animal is human.
Claim 16
Dependent Claim
10 words
The method of claim 9 wherein the animal is human.
Claim 17
Dependent Claim
10 words
The method of claim 10 wherein the animal is human.
Claim 18
Dependent Claim
10 words
The method of claim 11 wherein the animal is human.
Claim 19
Dependent Claim
21 words
The method of claim 13 wherein the human soft tissue which the microdispersion is placed is the submucosa of the urethra.
Claim 20
Dependent Claim
22 words
The method of claim 13 wherein the human soft tissue which the microdispersion is placed is the tissue of the gastrointestinal tract.
Claim 21
Dependent Claim
26 words
The method of claim 13 wherein the human soft tissue which the microdispersion is placed is a subureteric location appropriate for the treatment of vesicoureteral reflux.
Claim 22
Dependent Claim
44 words
The method of claim 12 wherein the microdispersion is administered from a container having a cylindrical storage area and an outlet and an end to said cylindrical storage area, the outlet having a removable sterile seal and the end having a movable sterile seal.
References Cited (Backward Citations)
US4595713A
Cited
US5442033A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-03-16 | 2001-09-15 | 2002-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-16 | 2005-09-15 | 2006-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-16 | 2009-09-15 | 2010-03-17 | $7700.00 | Window Closed / Lapsed |