US5704355A
Expired / Lapsed
US
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Non-invasive system for breast cancer detection
Assignee: Interstitial LLC
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Filing: 1995-06-21
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Granted: 1998-01-06
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Expires: 2015-06-21
Abstract
Abstract A system for detecting an incipient tumor in living tissue such as that of a human breast in accordance with differences in relative dielectric characteristics. A generator produces a non-ionizing electromagnetic input wave of preselected frequency, usually exceeding three gigahertz, and that input wave is used to illuminate the living tissue, being effectively focused into a small, discrete volume within the tissue to develop a non-ionizing electromagnetic wave at that position. The illumination location is moved over a portion of the living tissue in a predetermined scanning pattern. Scattered signal returns collected from the living tissue are collected to develop a scattered return signal. The scattered return signal is employed to detect any anomaly, caused by differences in relative dielectric characteristics, that is indicative of the presence of a tumor in the scanned living tissue.
Inventors
- 👤 Jack E. Bridges
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:40
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/43; A61B5/4306; A61B5/4312; A61B5/05; A61B5/0507; A61B6/00; A61B6/04; A61B6/0407; A61B6/0435; A61B6/50; A61B6/502
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
196 words
A non-invasive system utilizing non-ionizing electromagnetic millimeter waves of minimal thermal heating capacity for detection of a tumor in a breast, comprising: a generator for generating a non-ionizing high-frequency electromagnetic input wave; illumination means for creating an effectively focussed non-ionizing electromagnetic beam from the input wave and directing said beam to impinge upon an effective focal point at a predetermined position within a breast; wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue; a wave guide for applying the input wave from the generator to the breast through the illumination means; focal point shifting means, connected to the illumination means, for shifting the effective focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast; at least one scattered wave collector positioned to intercept scattered waves from the incremental volumes within the breast and develop a return signal representative of the scattered waves from within the breast; and a receiver, including a detector, connected to the scattered wave collector, for detecting anomalies in the return signal to identify a tumor and its location in the breast.
Claim 2
Dependent Claim
196 words
A non-invasive system utilizing non-ionizing electromagnetic millimeter waves of minimal thermal heating capacity for detection of a tumor in a breast, comprising: a generator for generating a non-ionizing high-frequency electromagnetic input wave; illumination means for creating an effectively focussed non-ionizing electromagnetic beam from the input wave and directing said beam to impinge upon an effective focal point at a predetermined position within a breast; wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue; a wave guide for applying the input wave from the generator to the breast through the illumination means; focal point shifting means, connected to the illumination means, for shifting the effective focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast; at least one scattered wave collector positioned to intercept scattered waves from the incremental volumes within the breast and develop a return signal representative of the scattered waves from within the breast; and a receiver, including a detector, connected to the scattered wave collector, for detecting anomalies in the return signal to identify a tumor and its location in the breast.
Claim 3
Dependent Claim
41 words
A non-invasive system for detection of a tumor in a breast according to claim 1 and further comprising: separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
Claim 4
Dependent Claim
23 words
A non-invasive system for detection of a tumor in a breast according to claim 2 in which the separator means includes a circulator.
Claim 5
Dependent Claim
39 words
A non-invasive system for detection of a tumor in a breast according to claim 2 in which the separator means includes polarization-responsive means for separating the input wave from the return signal based on polarization of the return signal.
Claim 6
Dependent Claim
70 words
A non-invasive system for detection of a tumor in a breast according to claim 2 in which: the separator means includes a pulse source of repetitive pulse signals; and the system further comprises display means, connected to the pulse source of the separator means and to the receiver, for displaying the returns as a function of time; the rise time for each pulse signal being no greater than 300 pico-seconds.
Claim 7
Dependent Claim
39 words
A non-invasive system for detection of a tumor in a breast according to claim 2 in which the pulse source is a part of a frequency-modulated pulse compression system that employs a frequency bandwidth of at least two gigahertz.
Claim 8
Dependent Claim
36 words
A non-invasive system for detection of a tumor in a breast according to claim 2 and further comprising compensation means for compensating for change in the dielectric constant of the breast as a function of frequency.
Claim 9
Dependent Claim
51 words
A non-invasive system for detection of a tumor in a breast, according to claim 2, in which a synthetic time-domain response is developed from the Fourier inversion of the complex input impedance data as the frequency of the illumination signal is progressively changed over a bandwidth of at least two gigahertz.
Claim 10
Dependent Claim
31 words
A non-invasive system for the detection of a tumor, according to claim 8, and further comprising means to compensate for the changes in the equipment behavior as a function of frequency.
Claim 11
Dependent Claim
32 words
A non-invasive system for the detection of a tumor, according to claim 8, and further comprising means to compensate for the path loss attenuation as the illuminating signal progresses into the breast.
Claim 12
Dependent Claim
53 words
A non-invasive system for detection of a tumor in a breast according to claim 1, in which: the reflection receiver is a part of the illumination means; and further comprising separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
Claim 13
Dependent Claim
73 words
A non-invasive system for detection of a tumor in a breast according to claim 1 in which: the illumination means comprises a globular antenna filled with a first dielectric medium; the illumination means further comprises a connecting device, connecting the antenna to the breast, filled with a second dielectric medium; and the dielectric constants of the breast, the first dielectric medium, and the second dielectric medium are all approximately equal to each other.
Claim 14
Dependent Claim
39 words
A non-invasive system for detection of a tumor in a breast according to claim 12 in which the globular antenna is of truncated ellipsoidal configuration and functions as a part of the transmitter and a part of the collector.
Claim 15
Dependent Claim
28 words
A non-invasive system for detection of a tumor in a breast, according to claim 12, in which the dielectric constants are in a range of four to twenty.
Claim 16
Dependent Claim
38 words
A non-invasive system for detection of a tumor in a breast according to claim 1 in which the focal point shifting means includes a mechanical scanner to change the location of the illuminator means relative to the breast.
Claim 17
Dependent Claim
55 words
A non-invasive system for detection of a tumor in a breast according to claim 15 and further comprising: focal point indication means, connected to the mechanical scanner; and imaging means, connected to the receiver and to the focal point indication means, for displaying an image of the breast including a representation of any tumor therein.
Claim 18
Dependent Claim
59 words
A non-invasive system for detection of a tumor in a breast according to claim 1 in which the connection from the generator to the receiver includes a phase shift circuit for shifting the input wave, as applied to one of the detectors, by an odd multiple of 90° relative to the input wave as supplied to the other detector.
Claim 19
Dependent Claim
25 words
A non-invasive system for detection of a tumor in a breast according to claim 17 in which each of the detectors is a hybrid tee.
Claim 20
Dependent Claim
43 words
A non-invasive system for detection of a tumor in a breast according to claim 1 in which the distance from the effective focal point to the effective aperture of the illuminator is no greater than four times the diameter of the effective aperture.
Claim 21
Dependent Claim
29 words
A non-invasive system for detection of a tumor in a breast, according to claim 1, comprising at least two scattered wave collectors, disposed on opposite sides of the breast.
Claim 22
Dependent Claim
23 words
A non-invasive system for detection of a tumor in a breast, according to claim 1, in which the receiver includes a directional coupler.
Claim 23
Dependent Claim
162 words
An illumination means for a non-invasive system for the detection of a tumor in a breast according to claim 1 comprising: an array of a plurality of independently excitable wave guides, each having an excitation end and an open end; means to note the position of the contact point of each illuminator wave guide between the open end of the wave guide and the surface of the breast, with no more than a minimum space between the wave guide and the breast; means to control the phase angle of the input wave of each illuminator wave guide at its contact point in accordance with the position of the contact point; and means to change the phase angle of the input wave of each illuminator wave guide at its contact point such that the individual waves that propagate from each of the illuminator wave guides into the breast add constructively at an effective focal point within a predetermined incremental volume within the breast.
Claim 24
Dependent Claim
36 words
An illumination means for a non-invasive system for detection of a breast tumor according to claim 22 and further comprising means to move the array of wave guides and the interface mechanically to scan the breast.
Claim 25
Dependent Claim
33 words
An illumination means according to claim 22 and further comprising: means to controllably and independently position the open ends of the illuminator wave guides into predetermined positions on the surface of the breast.
Claim 26
Dependent Claim
29 words
An illumination means according to claim 22 in which the illuminator wave guides are each filled with materials that have dielectric characteristics similar to that for the human breast.
Claim 27
Dependent Claim
131 words
A scattered wave collector for a non-invasive system for the detection of a tumor in the breast, including an illumination means according to claim 22, that further includes a scattered wave collector positioned to intercept waves scattered from the effective focal point, comprising: an array of a plurality of collector wave guides, each having an open end; means to note the position of the contact point of the open end of each collector wave guide and the surface of the breast; and means to control the phase angle of each of the waves collected by each collector wave guide such that the collected scattered waves that propagate from the effective focal point in the breast to each of the collector wave guides on the surface of the breast are constructively combined.
Claim 28
Dependent Claim
30 words
A wave collection means for a non-invasive system for the detection of a tumor, according to claim 26, in which the illuminator wave guides are also the collector wave guides.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-05 | 2001-07-07 | 2002-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-05 | 2005-07-07 | 2006-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-05 | 2009-07-07 | 2010-01-06 | $7700.00 | Window Closed / Lapsed |