US5681872A
Expired / Lapsed
US
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Bioactive load bearing bone graft compositions
Assignee: PAUL ROYALTY FUND LP
•
Filing: 1995-12-07
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Granted: 1997-10-28
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Expires: 2015-12-07
Abstract
Abstract Novel fillers comprising combeite glass-ceramic are provided. hardenable restorative compositions comprising particulate combeite glass-ceramic provide improved biocompatibility in bone restorations. Hard, shaped bodies for orthopaedic, dental and other uses are also provided.
Inventors
- 👤 Erik M. Erbe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/88; A61B17/8802; A61B17/68; A61B17/84; A61B17/86; A61B17/866; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/32; A61F2/44; A61F2/4455; A61L; A61L27/00; A61L27/02; A61L27/025; A61L27/40; A61L27/44; A61L27/446; A61L27/46; C; C03; C03C; C03C10/00; C03C10/0009; C08; C08K; C08K3/00; C08K3/34; A61F2/30767; A61F2/30771; A61F2002/30772; A61F2002/3208; A61F2/46; A61F2002/4631
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
35 words
A hardenable composition comprising a polymerizable matrix; and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite and irregular morphology.
Claim 2
Dependent Claim
35 words
A hardenable composition comprising a polymerizable matrix; and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite and irregular morphology.
Claim 3
Dependent Claim
19 words
The composition of claim 1 wherein combeite comprises at least about 3 percent by volume of said combeite glass-ceramic.
Claim 4
Dependent Claim
19 words
The composition of claim 1 wherein combeite comprises at least about 5 percent by volume of said combeite glass-ceramic.
Claim 5
Dependent Claim
19 words
The composition of claim 1 wherein combeite comprises at least about 10 percent by volume of said combeite glass-ceramic.
Claim 6
Dependent Claim
20 words
The composition of claim 1 wherein combeite comprises between about 5 and 50 percent by volume of said combeite glass-ceramic.
Claim 7
Dependent Claim
20 words
The composition of claim 1 wherein combeite comprises between about 10 and 20 percent by volume of said combeite glass-ceramic.
Claim 8
Dependent Claim
17 words
The composition of claim 1 wherein said combeite glass-ceramic is present in the form of heterogeneous particles.
Claim 9
Dependent Claim
22 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes greater than about 0.1 micron.
Claim 10
Dependent Claim
22 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes greater than about 0.2 micron.
Claim 11
Dependent Claim
22 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes less than about 300 microns.
Claim 12
Dependent Claim
22 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes less than about 100 microns.
Claim 13
Dependent Claim
23 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes between about 0.2 and 300 microns.
Claim 14
Dependent Claim
23 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes between about 0.2 and 100 microns.
Claim 15
Dependent Claim
23 words
The composition of claim 7 wherein at least 95% by weight of said particles have particle sizes between about 0.5 and 50 microns.
Claim 16
Dependent Claim
21 words
The composition of claim 1 wherein the combeite glass-ceramic filler has an X-ray diffraction spectrum substantially in accordance with FIG. 1.
Claim 17
Dependent Claim
21 words
The composition of claim 1 wherein said combeite glass-ceramic is present in the form of heterogeneous particles having an irregular morphology.
Claim 18
Dependent Claim
13 words
The composition of claim 1 wherein said combeite glass-ceramic filler is a blend.
Claim 19
Dependent Claim
17 words
The composition of claim 1 wherein said inorganic filler further comprises at least one additional inorganic material.
Claim 20
Dependent Claim
34 words
The composition of claim 18 wherein said additional inorganic material is hydroxyapatite, fluorapatite, oxyapatite, Wollastonite, anorthite, calcium fluoride, agrellite, devitrite, canasite, phlogopite, monotite, brushite, octocalcium phosphate, Whitlockite, tetracalcium phosphate, cordierite, Berlinite or mixtures thereof.
Claim 21
Dependent Claim
12 words
The composition of claim 1 wherein said polymerizable matrix comprises acrylic species.
Claim 22
Dependent Claim
13 words
The composition of claim 1 wherein said polymerizable matrix comprises a bisphenol-A dimethacrylate.
Claim 23
Dependent Claim
14 words
The composition of claim 21 wherein said bisphenol-A dimethacrylate is a bisphenol-A glycidyl dimethacrylate.
Claim 24
Dependent Claim
12 words
The composition of claim 22 wherein said dimethacrylate has been urethane modified.
Claim 25
Dependent Claim
15 words
The composition of claim 1 wherein the polymerizable matrix comprises a heat- or photo-polymerizing catalyst.
Claim 26
Dependent Claim
17 words
The composition of claim 24 wherein said catalyst comprises a quinone in admixture with a tertiary amine.
Claim 27
Dependent Claim
11 words
The composition of claim 24 wherein said catalyst comprises a peroxide.
Claim 28
Dependent Claim
18 words
The composition of claim 1 having a viscosity amenable to spatulation or delivery via a wide mouth syringe.
Claim 29
Dependent Claim
14 words
The composition of claim 27 having a viscosity between about 5,000 and 75,000 centipoises.
Claim 30
Dependent Claim
12 words
The composition of claim 1 wherein the regions of combeite comprise crystallites.
Claim 31
Dependent Claim
39 words
The composition of claim 1 wherein said combeite glass-ceramic filler has from 40-55% by weight SiO 2 from 10-32% by weight Na 2 O from 4-12% by weight P 2 O 5 , and from 10-32% by weight CaO.
Claim 32
Dependent Claim
39 words
The composition of claim 1 wherein said combeite glass-ceramic filler has from 42-48% by weight SiO 2 from 14-28% by weight Na 2 O from 5-10% by weight P 2 O 5 , and from 20-29% by weight CaO.
Claim 33
Dependent Claim
29 words
The composition of claim 1 wherein said combeite glass-ceramic filler has about 45% SiO 2 ; 24.5% Na 2 O; 24.5% CaO and 6% P 2 O 5 .
Claim 34
Dependent Claim
40 words
A hardenable, biocompatible restorative composition comprising at least one acrylic monomer; a polymerization catalyst; and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite crystallites.
Claim 35
Dependent Claim
40 words
A hardenable, biocompatible restorative composition comprising at least one acrylic monomer; a polymerization catalyst; and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite crystallites.
Claim 36
Independent Claim
47 words
A method for the preparation of a hardenable composition comprising blending together at least one acrylic monomer, at least one polymerization catalyst and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite.
Claim 37
Independent Claim
47 words
A method for the preparation of a hardenable composition comprising blending together at least one acrylic monomer, at least one polymerization catalyst and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite.
Claim 38
Dependent Claim
15 words
The method of claim 34 wherein said acrylic monomer comprises at least one bisphenol-A methacrylate.
Claim 39
Dependent Claim
13 words
The method of claim 34 wherein said acrylic monomer comprises bisphenol-A glycidyl dimethacrylate.
Claim 40
Dependent Claim
19 words
The method of claim 34 wherein combeite comprises at least about 3 percent by volume of said combeite glass-ceramic.
Claim 41
Dependent Claim
19 words
The method of claim 34 wherein combeite comprises at least about 5 percent by volume of said combeite glass-ceramic.
Claim 42
Dependent Claim
19 words
The method of claim 34 wherein combeite comprises at least about 10 percent by volume of said combeite glass-ceramic.
Claim 43
Dependent Claim
20 words
The method of claim 34 wherein combeite comprises between about 5 and 50 percent by volume of said combeite glass-ceramic.
References Cited (Backward Citations)
US2920971A
Cited
US3629187A
Cited
DE2208236A1
Cited
US4110184A
Cited
US3981736A
Cited
US4239113A
Cited
US4369262A
Cited
US4396476A
Cited
US4411625A
Cited
US4491453A
Cited
US4698373A
Cited
US4801528A
Cited
US4775646A
Cited
US4643982A
Cited
US4652534A
Cited
US4851046A
Cited
JPS6210939A
Cited
US4886843A
Cited
US5238491A
Cited
US5204106A
Cited
US5145520A
Cited
US5236458A
Cited
WO1993016738A1
Cited
US5527836A
Cited
US5336642A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-10-27 | 2001-04-28 | 2001-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-10-27 | 2005-04-28 | 2005-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-10-27 | 2009-04-28 | 2009-10-28 | $7700.00 | Window Closed / Lapsed |