US5631025A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Low sodium peritoneal dialysis solution
Assignee: Baxter International Inc
•
Filing: 1995-04-18
•
Granted: 1997-05-20
•
Expires: 2015-04-18
Abstract
Abstract An improved peritoneal dialysis solution and methods of administering same to a patient are provided. Pursuant to the present invention, the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities.
Inventors
- 👤 Ty R. Shockley
- 👤 Leo Martis
- 👤 Lee W. Henderson
- 👤 John Moran
- 👤 Masaaki Nakayama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:55
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/14
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
42 words
A peritoneal dialysis solution For providing a sustained osmotic gradient comprising: an osmotic agent including at least one polypeptide; and sodium in a concentration that is less than a sodium plasma concentration in a renal patient who is to receive the solution.
Claim 2
Dependent Claim
42 words
A peritoneal dialysis solution For providing a sustained osmotic gradient comprising: an osmotic agent including at least one polypeptide; and sodium in a concentration that is less than a sodium plasma concentration in a renal patient who is to receive the solution.
Claim 3
Dependent Claim
19 words
The peritoneal dialysis solution of claim 1 wherein the solution has a total osmolality of 300 to about 500.
Claim 4
Dependent Claim
17 words
The peritoneal dialysis solution of claim 1 wherein the sodium comprises approximately 35 to about 125 (meq/L).
Claim 5
Dependent Claim
69 words
The peritoneal dialysis solution of claim 1 wherein the osmotic agent has an osmolality of not more than 200 (mOsm/L) and the solution further comprises: 0.0 to about 4.0 (% w/v) dextrose; 0 to about 120 (mEq/L) sodium; 0 to about 100 (mEq/L) chloride; 0 to about 45 (mEq/L) lactate; 0 to about 45 (mEq/L) bicarbonate; 0.0 to about 4.0 (mEq/L) calcium; and 0.0 to about 4.0 (mEq/L) magnesium.
Claim 6
Independent Claim
43 words
A method for providing peritoneal dialysis to a patient comprising the step of administering a solution including sodium and an osmotic agent including at least one polypeptide to a patient, the sodium level being less than a plasma sodium concentration of the patient.
Claim 7
Independent Claim
43 words
A method for providing peritoneal dialysis to a patient comprising the step of administering a solution including sodium and an osmotic agent including at least one polypeptide to a patient, the sodium level being less than a plasma sodium concentration of the patient.
Claim 8
Dependent Claim
50 words
The method of claim 5 wherein the patient receives one dwell per day and the solution contains: ______________________________________
Osmotic agent (mOsm/L)
1-200
Dextrose (% w/v) 1.0-4.0
Sodium (mEq/L) 35-120
Chloride (mEq/L) 3-82
Combination of lactate and
35-40
bicarbonate (mEq/L)
Calcium (mEq/L) 2.5-3.5
Magnesium (mEq/L) 0.5-1.5
Total osmolality (mOsm/L)
300-500
______________________________________
Claim 9
Dependent Claim
42 words
The method of claim 5 wherein the solution contains: ______________________________________
Osmotic agent (mOsm/L)
1-200
Dextrose (% w/v) 1.0-4.0
Sodium (mEq/L) 100-125
Chloride (mEq/L) 55-87
Combination of lactate and
35-40
bicarbonate (mEq/L)
Calcium (mEq/L) 2.5-3.5
Magnesium (mEq/L) 0.5-1.5
Total osmolality (mOsm/L)
300-500
______________________________________
Claim 10
Dependent Claim
50 words
The method of claim 5 wherein the patient receives one dwell per day and the solution contains: ______________________________________
Osmotic agent (mOsm/L)
1-200
Dextrose (% w/v) 1.0-4.0
Sodium (mEq/L) 35-85
Chloride (mEq/L) 0-100
Combination of lactate and
30-45
bicarbonate (mEq/L)
Calcium (mEq/L) 0.0-4.0
Magnesium (mEq/L) 0.0-4.0
Total osmolality (mOsm/L)
300-500
______________________________________
Claim 11
Dependent Claim
42 words
The method of claim 5 wherein the solution contains: ______________________________________
Osmotic agent (mOsm/L)
1-200
Dextrose (% w/v) 1.0-4.0
Sodium (mEq/L) 90-130
Chloride (mEq/L) 39-95
Combination of lactate and
35-45
bicarbonate (mEq/L)
Calcium (mEq/L) 0.0-4.0
Magnesium (mEq/L) 0.0-2.0
Total osmolality (mOsm/L)
300-500
______________________________________
Claim 12
Independent Claim
59 words
A method for allowing increased salt intake in a diet of a dialysis patient comprising the step of administering to the dialysis patient a peritoneal dialysis solution comprising an osmotic agent that includes at least one polypeptide and sodium in a concentration that is less than a sodium concentration in the dialysis patient who is to receive the solution.
Claim 13
Independent Claim
59 words
A method for allowing increased salt intake in a diet of a dialysis patient comprising the step of administering to the dialysis patient a peritoneal dialysis solution comprising an osmotic agent that includes at least one polypeptide and sodium in a concentration that is less than a sodium concentration in the dialysis patient who is to receive the solution.
References Cited (Backward Citations)
US4404192A
Cited
US4489535A
Cited
US4722798A
Cited
US4663166A
Cited
US4663289A
Cited
US4668400A
Cited
US5091094A
Cited
US5211643A
Cited
US5032615A
Cited
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