US5631011A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
Assignee: Individual
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Filing: 1992-06-17
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Granted: 1997-05-20
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Expires: 2012-06-17
Abstract
Abstract A tissue treatment composition, especially an adhesive composition comprises (i) fibrin or fibrinogen and (ii) a biodegradable and biocompatible polymer capable of forming a viscous aqueous solution. In addition to glueing, the tissue adhesive composition may be used for slow-release of a drug incorporated into it or for anti-adherence purposes, for wound healing, etc.
Inventors
- 👤 Jonas Wadstrom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:29
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/043; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/36; A61K38/363; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0042; A61L27/00; A61L27/28; A61L27/34; A61P; A61P17/00; A61P43/00; A61F; A61F2/00; A61F2/0077; A61F2/02; A61F2/28; A61F2/30; A61F2/30756; A61F2/30767; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
76 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of i) a fibrin glue component comprising fibrin or fibrinogen, Factor XIII, thrombin, bivalent calcium, and ii) a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 2
Dependent Claim
76 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of i) a fibrin glue component comprising fibrin or fibrinogen, Factor XIII, thrombin, bivalent calcium, and ii) a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 3
Dependent Claim
70 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of Factor XIII, thrombin, bivalent calcium, and fibrin or fibrinogen, and a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 4
Dependent Claim
70 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of Factor XIII, thrombin, bivalent calcium, and fibrin or fibrinogen, and a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 5
Dependent Claim
78 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of Factor XIII, thrombin, bivalent calcium, and fibrin or fibrinogen; at least one protein which promotes wound healing; and a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 6
Dependent Claim
78 words
A tissue treatment composition to promote wound healing and reduce scar formation consisting essentially of Factor XIII, thrombin, bivalent calcium, and fibrin or fibrinogen; at least one protein which promotes wound healing; and a hyaluronic acid component which is hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof; wherein the hyaluronic acid component is present in a sufficient amount so that an aqueous solution formed from said composition has a viscosity of about 500 to about 1,000,000 cP.
Claim 7
Dependent Claim
27 words
A tissue treatment composition according to claim 3 wherein wherein said protein which promotes wound healing is selected from the group consisting of fibronectin, aprotinin and plasminogen.
Claim 8
Dependent Claim
25 words
A composition according to claim 3 wherein the protein is selected from the group consisting of serum proteins, tissue growth factors, hormones, and chemotactic proteins.
Claim 9
Dependent Claim
16 words
A film or sheet for surgical use comprising a tissue treatment composition according to claim 2.
Claim 10
Dependent Claim
24 words
A method of promoting tissue wound healing which comprises administering to a tissue wound an effective amount of a composition according to claim 2.
Claim 11
Dependent Claim
22 words
A method of promoting tissue anti-adherence which comprises administering to a tissue an effective amount of a composition according to claim 2.
Claim 12
Dependent Claim
13 words
A coating for prosthetic materials which comprises a composition according to claim 2.
Claim 13
Dependent Claim
13 words
A carrier of cellular transplants which comprises a composition according to claim 2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-05-19 | 2000-11-18 | 2001-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-05-19 | 2004-11-18 | 2005-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-05-19 | 2008-11-18 | 2009-05-20 | $7700.00 | Window Closed / Lapsed |