US5618552A
Expired / Lapsed
US
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Absorbable polyoxaesters
Assignee: Ethicon Inc
•
Filing: 1996-03-05
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Granted: 1997-04-08
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Expires: 2016-03-05
Abstract
Abstract The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof.
Inventors
- 👤 Rao S. Bezwada
- 👤 Dennis D. Jamiolkowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:10
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/668; C08G63/672; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/26; A61L15/42; A61L15/60; A61L15/64; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/52; A61L27/58; A61L29/00; A61L29/04; A61L29/049; A61L29/06; A61L29/14; A61L29/145; A61L31/00; A61L31/04; A61L31/041; A61L31/06; A61L31/14; A61L31/148; C08G63/664; C08G69/00; C08G69/40; C08G69/44; C08L; C08L67/00; C08L67/02; C08L67/025; C09; C09D; C09D167/00; C08L101/00; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/1355; Y10T428/1362; Y10T428/24; Y10T428/249921; Y10T428/249953; Y10T428/29; Y10T428/2904; Y10T428/2913; Y10T428/2933; Y10T428/294; Y10T428/2942; Y10T428/2947; Y10T428/31504; Y10T428/31551
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
342 words
An aliphatic polyoxaesters comprising a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --F(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 2
Dependent Claim
342 words
An aliphatic polyoxaesters comprising a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --F(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 3
Dependent Claim
29 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)C(O)--(O--R.sub.4).sub.A --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 4
Dependent Claim
46 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S (C(O)--R.sub.5 --O).sub.B ].sub.W wherein S is integers in the range of from about 1 to about 10,000 and W is integers in the range of from about 1 to about 1,000.
Claim 5
Dependent Claim
49 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 6
Independent Claim
352 words
A device made from an aliphatic polyoxaesters comprising a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 ----CR 8 H--CH 2 --, --(CH 2 ) 5 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 7
Independent Claim
352 words
A device made from an aliphatic polyoxaesters comprising a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 ----CR 8 H--CH 2 --, --(CH 2 ) 5 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 8
Dependent Claim
13 words
The device of claim 5 wherein the device is an absorbable surgical device.
Claim 9
Dependent Claim
68 words
The absorbable surgical device of claim 6 wherein the absorbable surgical device is selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauze, fabrics, sheets, felts, sponges, gauze bandages, arterial graft, bandages for skin surfaces, suture knot clip, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin.
Claim 10
Dependent Claim
13 words
The absorbable surgical device of claim 6 wherein the device is a filament.
Claim 11
Dependent Claim
13 words
The filament of claim 8 wherein the filament is attached to a needle.
Claim 12
Independent Claim
392 words
A device coated with an absorbable coating comprising an aliphatic polyoxaesters having a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 5 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200 wherein the inherent viscosity of the polyoxaester is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25° C.
Claim 13
Independent Claim
392 words
A device coated with an absorbable coating comprising an aliphatic polyoxaesters having a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C(O)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 5 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200 wherein the inherent viscosity of the polyoxaester is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25° C.
Claim 14
Dependent Claim
11 words
The device of claim 10 wherein the device is a suture.
Claim 15
Dependent Claim
13 words
The device of claim 11 wherein the suture is attached to a needle.
Claim 16
Dependent Claim
357 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaester having a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C)I)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 17
Dependent Claim
357 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaester having a first divalent repeating unit of formula I: [O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--O--R.sub.4 --].sub.A, II [--O--R.sub.5 --C)I)--].sub.B, and III ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --CH 2 ) F --C(O)--CH 2 --; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 18
Dependent Claim
29 words
The device of claim 5 wherein the aliphatic polyoxaesters have the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 19
Dependent Claim
48 words
The device of claim 5 wherein the aliphatic polyoxaesters have the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S (C(O)--R.sub.5 --O).sub.B ].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 20
Dependent Claim
48 words
The device of claim 5 wherein the aliphatic polyoxaesters have the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 21
Dependent Claim
34 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaesters have the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 22
Dependent Claim
53 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaesters have the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S (C(O)--R.sub.5 --O).sub.B ]W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 23
Dependent Claim
54 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaesters have the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 24
Dependent Claim
31 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaester has the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 25
Dependent Claim
50 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaester has the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4).sub.A --O).sub.S (C(O)--R.sub.5 --O).sub.B ].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 26
Dependent Claim
50 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaester has the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.4)--O).sub.S ([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
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