US5607918A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular endothelial growth factor-B and DNA coding therefor
Assignee: Ludwig Cancer Research
•
Filing: 1995-06-06
•
Granted: 1997-03-04
•
Expires: 2015-06-06
Abstract
Abstract VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Inventors
- 👤 Ulf Eriksson
- 👤 Birgitta Olofsson
- 👤 Kari Alitalo
- 👤 Katri Pajusola
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:43
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
91 words
An isolated protein having the property of promoting proliferation of endothelial cells or mesodermal cells, said isolated protein comprising a sequence of amino acids selected from the group consisting of the amino acid sequence of FIG. 1 (SEQ ID NO:2), the amino acid sequence of FIG. 2 (SEQ ID NO:3), the amino acid sequence of FIG. 4 (SEQ ID NO:5), the amino acid sequence of FIG. 6 (SEQ ID NO:7), the amino acid sequence of FIG. 8 (SEQ ID NO:9), and the amino acid sequence of FIG. 11 (SEQ ID NO:11).
Claim 2
Dependent Claim
91 words
An isolated protein having the property of promoting proliferation of endothelial cells or mesodermal cells, said isolated protein comprising a sequence of amino acids selected from the group consisting of the amino acid sequence of FIG. 1 (SEQ ID NO:2), the amino acid sequence of FIG. 2 (SEQ ID NO:3), the amino acid sequence of FIG. 4 (SEQ ID NO:5), the amino acid sequence of FIG. 6 (SEQ ID NO:7), the amino acid sequence of FIG. 8 (SEQ ID NO:9), and the amino acid sequence of FIG. 11 (SEQ ID NO:11).
Claim 3
Dependent Claim
21 words
An isolated protein according to claim 1, wherein said protein comprises the amino acid sequence of FIG. 1 (SEQ ID NO:2).
Claim 4
Dependent Claim
22 words
An isolated protein according to claim 1, wherein said isolated protein comprises the amino acid sequence of FIG. 2 (SEQ ID NO:3).
Claim 5
Dependent Claim
22 words
An isolated protein according to claim 1, wherein said isolated protein comprises the amino acid sequence of FIG. 4 (SEQ ID NO:5).
Claim 6
Dependent Claim
22 words
An isolated protein according to claim 1, wherein said isolated protein comprises the amino acid sequence of FIG. 6 (SEQ ID NO:7).
Claim 7
Dependent Claim
22 words
An isolated protein according to claim 1, wherein said isolated protein comprises the amino acid sequence of FIG. 8 (SEQ ID NO:9).
Claim 8
Dependent Claim
22 words
An isolated protein according to claim 1, wherein said isolated protein comprises the amino acid sequence of FIG. 11 (SEQ ID NO:11).
Claim 9
Dependent Claim
15 words
An isolated protein according to claim 1, wherein said isolated protein is a mammalian protein.
Claim 10
Dependent Claim
15 words
An isolated protein according to claim 8, wherein said mammalian protein is a murine protein.
Claim 11
Dependent Claim
15 words
An isolated protein according to claim 8, wherein said mammalian protein is a human protein.
Claim 12
Dependent Claim
17 words
An isolated protein according to claim 1, wherein said isolated protein promotes proliferation of vascular endothelial cells.
Claim 13
Dependent Claim
73 words
An isolated protein produced by expression of a DNA selected from the group consisting of the DNA of FIGS. 1 and 2 (SEQ ID NO:1), the DNA of FIG. 3 (SEQ ID NO:4), the DNA of FIG. 5 (SEQ ID NO:6), the DNA of FIG. 7 (SEQ ID NO:8), the DNA of FIG. 10 (SEQ ID NO:10), and DNA which hybridizes under stringent conditions with at least one of the foregoing DNA sequences.
Claim 14
Dependent Claim
73 words
An isolated protein produced by expression of a DNA selected from the group consisting of the DNA of FIGS. 1 and 2 (SEQ ID NO:1), the DNA of FIG. 3 (SEQ ID NO:4), the DNA of FIG. 5 (SEQ ID NO:6), the DNA of FIG. 7 (SEQ ID NO:8), the DNA of FIG. 10 (SEQ ID NO:10), and DNA which hybridizes under stringent conditions with at least one of the foregoing DNA sequences.
Claim 15
Dependent Claim
29 words
A pharmaceutical composition comprising an effective endothelial or mesodermal cell proliferation promoting amount of an isolated protein according to claim 1, and at least one pharmaceutical carrier or diluent.
References Cited (Backward Citations)
WO1995024473A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-03 | 2000-09-02 | 2001-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-03 | 2004-09-02 | 2005-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-03 | 2008-09-02 | 2009-03-04 | $7700.00 | Window Closed / Lapsed |