US5580923A
Expired / Lapsed
US
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Anti-adhesion films and compositions for medical use
Assignee: Angiotech Pharmaceuticals Inc
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Filing: 1995-03-14
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Granted: 1996-12-03
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Expires: 2015-03-14
Abstract
Abstract Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient via the binding agent. Preferred binding agents comprise substrate-reactive and tissue-selective functional groups. Anti-adhesion compositions useful for the formation of such films are also disclosed.
Inventors
- 👤 Jeffrey E. Yeung
- 👤 George H. Chu
- 👤 Frank A. Delustro
- 👤 Woonza M. Rhee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:30
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61L31/042
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
34 words
An anti-adhesion composition for treatment of receptive tissue comprising: (i) a substrate material; and (ii) an anti-adhesion binding agent, wherein said anti-adhesion agent further comprises a substrate-reactive functional group and a tissue-selective functional group.
Claim 2
Dependent Claim
34 words
An anti-adhesion composition for treatment of receptive tissue comprising: (i) a substrate material; and (ii) an anti-adhesion binding agent, wherein said anti-adhesion agent further comprises a substrate-reactive functional group and a tissue-selective functional group.
Claim 3
Dependent Claim
12 words
The anti-adhesion composition of claim 1, wherein said substrate material comprises collagen.
Claim 4
Dependent Claim
15 words
The anti-adhesion composition of claim 1, wherein said tissue-selective group is a sulfhydryl-selective functional group.
Claim 5
Dependent Claim
16 words
The anti-adhesion composition of claim 2, wherein said binding agent comprises a derivative of polyethylene glycol.
Claim 6
Dependent Claim
46 words
The anti-adhesion composition of claim 3, wherein said sulfhydryl-selective functional group is selected from the group consisting of: (i) a disulfide group; (ii) a haloacetyl group; (iii) a halomethyl ester group; (iv) a β-Nitrovinyl group; (v) an N-hydroxy succinimidyl ester group; and (vi) a maleimidyl group.
Claim 7
Dependent Claim
36 words
The anti-adhesion composition of claim 5, wherein said sulfhydryl-selective functional group is selected from the group consisting of: (i) a disulfide group; (ii) a haloacetyl group; (iii) a halomethyl ester group; and (iv) a β-Nitrovinyl group.
Claim 8
Dependent Claim
15 words
The anti-adhesion composition of claim 6, wherein said sulfhydryl-selective functional group is a disulfide group.
Claim 9
Dependent Claim
19 words
The anti-adhesion composition of claim 7, wherein said disulfide group is a 2-pyridinyl-disulfide group or a 3-carboxylic acid-4-nitro-phenyl-disulfide group.
Claim 10
Dependent Claim
64 words
The anti-adhesion composition of claim 5, wherein said substrate-reactive functional group is selected from the group consisting of: (i) an active ester group; (ii) a haloacetyl group; (iii) an azide group; (iv) a haloformate group; (v) a sulfonyl halide group; (vi) an isocyanate group; (vii) an isothiocyanate group; (viii) an acid anhydride group; (ix) an acid halide group; and (x) an imidate ester group.
Claim 11
Dependent Claim
32 words
The anti-adhesion composition of claim 5, wherein said substrate-reactive functional group is selected from the group consisting of: (i) an active ester group; (ii) a haloacetyl group; and (iii) an azide group.
Claim 12
Dependent Claim
16 words
The anti-adhesion composition of claim 1, wherein said tissue-selective functional group is an amine-selective functional group.
Claim 13
Dependent Claim
16 words
The anti-adhesion composition of claim 1, wherein said tissue-selective functional group is an active ester group.
Claim 14
Dependent Claim
16 words
The anti-adhesion composition of claim 2, wherein said tissue-reactive functional group is an active ether group.
Claim 15
Dependent Claim
29 words
The anti-adhesion composition of claim 11, wherein said amine-selective functional group is selected from the group consisting of an active ester group, an active ether group, and combinations thereof.
Claim 16
Dependent Claim
16 words
The anti-adhesion composition of claim 4, wherein said substrate-reactive functional group is an active ester group.
Claim 17
Dependent Claim
16 words
The anti-adhesion composition of claim 4, wherein said substrate-reactive functional group is an active ether group.
Claim 18
Dependent Claim
22 words
The anti-adhesion composition of claim 5 wherein said substrate-reactive functional group is an N-succinimidyl active ester group or a 2,4-dinitrophenyl active ester.
Claim 19
Dependent Claim
35 words
An anti-adhesion device for treatment of receptive tissue, said device comprising at least one layer of substrate material covalently bonded to an anti-adhesion binding agent, wherein said anti-adhesion agent further comprises a tissue-selective functional group.
Claim 20
Dependent Claim
35 words
An anti-adhesion device for treatment of receptive tissue, said device comprising at least one layer of substrate material covalently bonded to an anti-adhesion binding agent, wherein said anti-adhesion agent further comprises a tissue-selective functional group.
Claim 21
Dependent Claim
49 words
The anti-adhesion device of claim 18, wherein receptive tissue to which said device is to be covalently bonded has been treated to convert disulfide groups or primary amino groups on the surface of said tissue to sulfhydryl groups prior to covalent bonding of said substrate material to said tissue.
Claim 22
Dependent Claim
15 words
The anti-adhesion device of claim 18 or claim 19, wherein said substrate material comprises collagen.
Claim 23
Dependent Claim
14 words
The anti-adhesion device of claim 18, wherein said tissue-selective group is a sulfhydryl-selective group.
Claim 24
Dependent Claim
15 words
The anti-adhesion device of claim 18, wherein said tissue-selective functional group is an amine-comprising group.
Claim 25
Dependent Claim
19 words
The anti-adhesion device of claim 18 or claim 19, wherein said binding agent comprises a derivative of polyethylene glycol.
Claim 26
Dependent Claim
34 words
A method for preventing the formation of an adhesion, comprising the steps of: (i) providing the anti-adhesion device of claim 18 or claim 19; and (ii) covalently bonding said anti-adhesion device to receptive tissue.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-03 | 2000-06-03 | 2000-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-03 | 2004-06-03 | 2004-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-03 | 2008-06-03 | 2008-12-03 | $7700.00 | Window Closed / Lapsed |