US5569197A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery guidewire
Assignee: OOO ROSCARDIOINVEST
•
Filing: 1994-12-21
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Granted: 1996-10-29
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Expires: 2014-12-21
Abstract
Abstract This invention relates to a drug delivery device having a hollow tube which is configured to serve as a guide wire for intraluminal procedures. The distal portion of the tube has at least one opening which has a diameter suitable for the infusion of a drug formulation therethrough. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this drug delivery device in thrombolytic and other intraluminal procedures.
Inventors
- 👤 Michael N. Helmus
- 👤 Michael R. Forman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:46
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/09; A61F; A61F2/00; A61F2/95; A61M2025/091; A61M2025/09175; A61M25/0067; A61M25/0068; A61M25/007; A61M25/10; A61M25/104
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
67 words
A drug delivery device comprising: a hollow tube including means sized and configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein; the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen.
Claim 2
Dependent Claim
67 words
A drug delivery device comprising: a hollow tube including means sized and configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein; the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen.
Claim 3
Dependent Claim
17 words
The drug delivery device of claim 1 wherein the hollow tube is formed from a superelastic material.
Claim 4
Dependent Claim
30 words
The drug delivery device of claim 2 wherein the superelastic material is selected from the group consisting of a nickel-titanium alloy, nickel and its alloys, and titanium and its alloys.
Claim 5
Dependent Claim
27 words
The drug delivery device of claim 2 wherein the tube has an outer diameter of from about 0.010 inches (0.025 cm) to about 0.038 inches (0.097 cm).
Claim 6
Dependent Claim
20 words
The drug delivery device of claim 4 wherein the tube has an outer diameter of about 0.014 inches (0.036 cm).
Claim 7
Dependent Claim
26 words
The drug delivery device of claim 4 wherein the lumen has a diameter of from about 0.005 inches (0.013 cm) to about 0.035 inches (0.089 cm).
Claim 8
Dependent Claim
22 words
The drug delivery device of claim 1 further comprising a flexible distal segment connected to the distal portion of the hollow tube.
Claim 9
Dependent Claim
18 words
The drug delivery device of claim 7 wherein the flexible distal segment comprises a generally solid core wire.
Claim 10
Dependent Claim
21 words
The drug delivery device of claim 8 further comprising a helical coil spring arranged coaxially about the generally solid core wire.
Claim 11
Dependent Claim
91 words
A drug delivery-dilatation device, comprising: a hollow tube including means configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein, the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen; and a balloon dilatation catheter comprising a dilatation balloon attached to a catheter, the catheter having a guide wire lumen adapted to receive the hollow tube.
Claim 12
Dependent Claim
91 words
A drug delivery-dilatation device, comprising: a hollow tube including means configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein, the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen; and a balloon dilatation catheter comprising a dilatation balloon attached to a catheter, the catheter having a guide wire lumen adapted to receive the hollow tube.
Claim 13
Dependent Claim
17 words
The drug delivery-dilatation device of claim 10 wherein the hollow tube is formed from a superelastic material.
Claim 14
Dependent Claim
30 words
The drug delivery-dilatation device of claim 11 wherein the superelastic material is selected from the group consisting of a nickel-titanium alloy, nickel and its alloys, and titanium and its alloys.
Claim 15
Dependent Claim
27 words
The drug delivery-dilatation device of claim 11 wherein the tube has an outer diameter of from about 0.010 inches (0.025 cm) to about 0.038 inches (0.097 cm).
Claim 16
Dependent Claim
20 words
The drug delivery-dilatation device of claim 13 wherein the tube has an outer diameter of about 0.014 inches (0.036 cm).
Claim 17
Dependent Claim
26 words
The drug delivery-dilatation device of claim 13 wherein the lumen has a diameter of from about 0.005 inches (0.013 cm) to about 0.035 inches (0.089 cm).
Claim 18
Dependent Claim
22 words
The drug delivery-dilatation device of claim 10 wherein the catheter guide wire lumen is at least partially disposed about the hollow tube.
Claim 19
Dependent Claim
82 words
A drug delivery-stent deployment device, comprising: a hollow tube including means configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein, the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen; and a stent deployment catheter having a guide wire lumen adapted to receive the hollow tube.
Claim 20
Dependent Claim
82 words
A drug delivery-stent deployment device, comprising: a hollow tube including means configured to serve as a guidewire for intraluminal devices and having a proximal portion and a distal portion and defining a lumen therein, the distal portion of the tube having at least one opening having a diameter suitable for the infusion of a drug formulation therethrough, the opening being in fluid communication with the lumen; and a stent deployment catheter having a guide wire lumen adapted to receive the hollow tube.
Claim 21
Dependent Claim
18 words
The drug delivery-stent deployment device of claim 17 wherein the hollow tube is formed from a superelastic material.
Claim 22
Dependent Claim
31 words
The drug delivery-stent deployment device of claim 18 wherein the superelastic material is selected from the group consisting of a nickel-titanium alloy, nickel and its alloys, and titanium and its alloys.
Claim 23
Dependent Claim
28 words
The drug delivery-stent deployment device of claim 18 wherein the tube has an outer diameter of from about 0.010 inches (0.025 cm) to about 0.038 inches (0.097 cm).
Claim 24
Dependent Claim
21 words
The drug delivery-stent deployment device of claim 20 wherein the tube has an outer diameter of about 0.014 inches (0.036 cm).
Claim 25
Dependent Claim
27 words
The drug delivery-stent deployment device of claim 20 wherein the lumen has a diameter of from about 0.005 inches (0.013 cm) to about 0.035 inches (0.089 cm).
Claim 26
Dependent Claim
23 words
The drug delivery-stent deployment device of claim 17 wherein the catheter guide wire lumen is at least partially disposed about the hollow tube.
Claim 27
Independent Claim
104 words
A method for removing a thrombotic blockage using a drug delivery device with a hollow tube having a proximal portion and a distal portion and defining a lumen therein, wherein the distal portion has a drug delivery portion having at least one opening having a diameter suitable for the infusion of a thrombolytic agent therethrough, the opening being in fluid communication with the lumen, the method comprising: advancing the drug delivery device through a patient's vasculature so that the drug delivery portion is located at about a site of thrombotic obstruction; and infusing the thrombolytic agent through the opening to reduce the thrombotic obstruction.
Claim 28
Independent Claim
104 words
A method for removing a thrombotic blockage using a drug delivery device with a hollow tube having a proximal portion and a distal portion and defining a lumen therein, wherein the distal portion has a drug delivery portion having at least one opening having a diameter suitable for the infusion of a thrombolytic agent therethrough, the opening being in fluid communication with the lumen, the method comprising: advancing the drug delivery device through a patient's vasculature so that the drug delivery portion is located at about a site of thrombotic obstruction; and infusing the thrombolytic agent through the opening to reduce the thrombotic obstruction.
Claim 29
Dependent Claim
55 words
The method of claim 24, wherein an underlying lesion is revealed after the thrombolytic agents are infused, the method further comprising: advancing a balloon dilatation catheter over at least part of the hollow tube so that a dilatation balloon is located adjacent to the underlying lesion; and dilatating the underlying lesion with the dilatation balloon.
Claim 30
Dependent Claim
34 words
The method of claim 24 further comprising: advancing a stent delivery catheter with a stent contained therein over at least part of the hollow tube; and deploying the stent from the stent delivery catheter.
Claim 31
Dependent Claim
40 words
The method of claim 26, further comprising: withdrawing the stent delivery catheter; advancing a balloon catheter over at least part of the hollow tube until a balloon is located within the stent; and inflating the balloon to expand the stent.
Claim 32
Dependent Claim
27 words
The drug delivery device of claim 24 wherein the tube has an outer diameter of from about 0.010 inches (0.025 cm) to about 0.038 inches (0.097 cm).
Claim 33
Dependent Claim
20 words
The drug delivery device of claim 28 wherein the tube has an outer diameter of about 0.014 inches (0.036 cm).
Claim 34
Dependent Claim
26 words
The drug delivery device of claim 28 wherein the lumen has a diameter of from about 0.005 inches (0.013 cm) to about 0.035 inches (0.089 cm).
Claim 35
Dependent Claim
28 words
The drug delivery device of claim 1 wherein the distal portion of the tube has a distal tip and at least one opening is proximal the distal tip.
Claim 36
Dependent Claim
28 words
The drug delivery device of claim 10 wherein the distal portion of the tube has a distal tip and at least one opening is proximal the distal tip.
Claim 37
Dependent Claim
28 words
The drug delivery device of claim 17 wherein the distal portion of the tube has a distal tip and at least one opening is proximal the distal tip.
Claim 38
Dependent Claim
28 words
The drug delivery device of claim 24 wherein the distal portion of the tube has a distal tip and at least one opening is proximal the distal tip.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-29 | 2000-04-29 | 2000-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-29 | 2004-04-29 | 2004-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-29 | 2008-04-29 | 2008-10-29 | $7700.00 | Window Closed / Lapsed |