US5544656A
Expired / Lapsed
US
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Method and apparatus for myocardial wall measurement
Assignee: University of California
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Filing: 1994-12-02
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Granted: 1996-08-13
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Expires: 2014-12-02
Abstract
Abstract A closed-loop single-crystal ultrasonic sonomicrometer capable of identifying the myocardial muscle/blood interface and continuously tracking this interface throughout the cardiac cycle using a unique piezoelectric transducer. During steady-state, a reference volume SV m is adjusted so that it remains within the myocardium while half of an interface volume SV i is in the myocardium and one-half is in the ventricular chamber. Every 100 ns, a 0.5 μs duration ultrasonic burst of 10 MHz pulses is transmitted from the piezoelectric transducer. Myocardial layers and red blood cells in the ventricular chamber reflect the ultrasonic energy back to the piezoelectric transducer. The echoes are then amplified and applied to a Doppler decoder, which then mixes them with a local oscillator signal having a 2 kHz offset relative to the transmitted signal. When the offset signal is mixed with returning ultrasonic echoes, the resulting Doppler signals are shifted in the frequency domain by 2 kHz. The received Doppler signal is then processed by an amplitude-locked-loop circuit which maintains the steady state throughout the cardiac cycle. Initially, the Doppler decoded signal is sampled at two distinct time intervals corresponding to sample volumes SV m and SV i . The outputs from these two sample volumes are then bandpass filtered to remove frequencies contributed by red blood cells. The true RMS values from both sample volumes then are compared and an error signal is generated. The integrated error signal is adjusted for correct depth placement and applied to a voltage-controlled delay circuit. The amplitude-locked-loop circuit continuously adjusts the position of the two sampled volumes SV m and SV i , so that they always remain within, and thereby effectively track, the muscle/blood interface. As a result, the apparatus can measure absolute myocardial wall thickness.
Inventors
- 👤 Koullis F. Pitsillides
- 👤 John C. Longhurst
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:47
CPC Classifications
A; A61; A61B; A61B8/00; A61B8/08; A61B8/0858; G; G01; G01S; G01S15/00; G01S15/02; G01S15/06; G01S15/08; G01S15/10; G01S15/18; G01S15/66
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
180 words
An apparatus for measuring the thickness of the myocardial wall in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) transducer means electrically coupled to said transmitting means and said receiving means for emitting and detecting said transmitted and received ultrasonic signals; and (d) means associated with said transmitting and receiving means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium, for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface, for comparing signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle, and for generating an output signal indicative of a differential in said signal levels.
Claim 2
Independent Claim
180 words
An apparatus for measuring the thickness of the myocardial wall in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) transducer means electrically coupled to said transmitting means and said receiving means for emitting and detecting said transmitted and received ultrasonic signals; and (d) means associated with said transmitting and receiving means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium, for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface, for comparing signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle, and for generating an output signal indicative of a differential in said signal levels.
Claim 3
Dependent Claim
42 words
An apparatus as recited in claim 1, further comprising: (a) sampling means for sampling said received signal at successive time intervals; and (b) means for adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface.
Claim 4
Dependent Claim
136 words
A method of measuring myocardial wall thickness using an apparatus as recited in claim 2, comprising the steps of: (a) subjecting said heart to a transmitted signal comprising ultrasonic pulses generated by said transmitting means and directed toward said heart by said transducer means; (b) receiving, with said transducer means and said receiving means, a received signal which is a reflection of said transmitted signal from said heart; (c) positioning said reference volume within the myocardium of said heart; (d) positioning one-half of said interface volume within said myocardium and one-half of said interface volume within the adjacent ventricular chamber; (e) sampling said received signal at successive time intervals; (f) comparing signal levels at said successive time intervals during a cardiac cycle; and (g) generating an output signal indicative of a differential in said signal levels.
Claim 5
Dependent Claim
32 words
A method as recited in claim 3, further comprising the step of adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface of said heart.
Claim 6
Dependent Claim
27 words
A method as recited in claim 4, further comprising the step of integrating the differential in signal levels throughout the cardiac cycle to determine myocardial wall thickness.
Claim 7
Dependent Claim
173 words
An apparatus as recited in claim 1, wherein said transducer means comprises: (a) a generally cylindrical piezoelectric substrate, said substrate having first and second generally planar surfaces, said substrate having a central axis extending between said first and second surfaces; (b) a transmitting electrode deposited on said first surface of said substrate, said transmitting electrode having first and second generally planar surfaces, said second surface of said transmitting electrode positioned adjacent to said first surface of said substrate; (c) a receiving electrode deposited on said first surface of said substrate, said receiving electrode having first and second generally planar surfaces, said second surface of said receiving electrode positioned adjacent to said first surface of said substrate; (d) said transmitting and receiving electrodes being coaxially aligned with said central axis and separated by an annular groove extending from said first surfaces of said electrodes to said first surface of said substrate, said annular groove being coaxially aligned with said central axis; and (e) a common electrode deposited on said second surface of said substrate.
Claim 8
Dependent Claim
97 words
An apparatus as recited in claim 1, wherein said transducer means comprises: (a) a piezoelectric substrate layer having first and second surfaces; (b) first and second concentric electrode layers adjacent to said first surface of said substrate; and (c) a third electrode layer adjacent to said second surface of said substrate; (d) wherein said first and second concentric electrode layers are spaced apart from said third electrode layer, and wherein said first and second electrode layers are separated by an annular groove extending between said first and second electrode layers and said first surface of said substrate.
Claim 9
Dependent Claim
350 words
A single-crystal sonomicrometer apparatus for measuring myocardial wall thickness in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) a generally cylindrical piezoelectric substrate, said substrate having first and second generally planar surfaces, said substrate having a central axis extending between said first and second surfaces; (d) a transmitting electrode deposited on said first surface of said substrate, said transmitting electrode having first and second generally planar surfaces, said second surface of said transmitting electrode positioned adjacent to said first surface of said substrate; (e) a receiving electrode deposited on said first surface of said substrate, said receiving electrode having first and second generally planar surfaces, said second surface of said receiving electrode positioned adjacent to said first surface of said substrate; (f) said transmitting and receiving electrodes being coaxially aligned with said central axis and separated by an annular groove extending from said first surfaces of said electrodes to said first surface of said substrate, said annular groove being coaxially aligned with said central axis; (g) a common electrode deposited on said second surface of said substrate; (h) said transmitting electrode electrically coupled to said transmitting means, said receiving electrode electrically coupled to said receiving means, said common electrode electrically coupled to said transmitting means and said receiving means; (i) means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (j) means for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (k) means for sampling signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (l) means for comparing sampled signal levels from said reference volume and said interface volume at successive time intervals.
Claim 10
Dependent Claim
350 words
A single-crystal sonomicrometer apparatus for measuring myocardial wall thickness in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) a generally cylindrical piezoelectric substrate, said substrate having first and second generally planar surfaces, said substrate having a central axis extending between said first and second surfaces; (d) a transmitting electrode deposited on said first surface of said substrate, said transmitting electrode having first and second generally planar surfaces, said second surface of said transmitting electrode positioned adjacent to said first surface of said substrate; (e) a receiving electrode deposited on said first surface of said substrate, said receiving electrode having first and second generally planar surfaces, said second surface of said receiving electrode positioned adjacent to said first surface of said substrate; (f) said transmitting and receiving electrodes being coaxially aligned with said central axis and separated by an annular groove extending from said first surfaces of said electrodes to said first surface of said substrate, said annular groove being coaxially aligned with said central axis; (g) a common electrode deposited on said second surface of said substrate; (h) said transmitting electrode electrically coupled to said transmitting means, said receiving electrode electrically coupled to said receiving means, said common electrode electrically coupled to said transmitting means and said receiving means; (i) means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (j) means for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (k) means for sampling signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (l) means for comparing sampled signal levels from said reference volume and said interface volume at successive time intervals.
Claim 11
Dependent Claim
118 words
A method of measuring myocardial wall thickness using the apparatus recited in claim 8, comprising the steps of: (a) subjecting said heart to a transmitted signal comprising ultrasonic pulses generated by said transmitting means (b) receiving an ultrasonic signal which is a reflection of said transmitted signal from said heart; (c) positioning said reference volume within the myocardium of said heart; (d) positioning one-half of said interface volume within said myocardium and one-half of said interface volume within the adjacent ventricular chamber; (e) sampling said received signal at successive time intervals; (f) comparing signal levels at said successive time intervals during a cardiac cycle; and (g) generating an output signal indicative of a differential in said signal levels.
Claim 12
Dependent Claim
32 words
A method as recited in claim 9, further comprising the step of adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface of said heart.
Claim 13
Dependent Claim
27 words
A method as recited in claim 10, further comprising the step of integrating the differential in signal levels throughout the cardiac cycle to determine myocardial wall thickness.
Claim 14
Dependent Claim
277 words
A sonomicrometer apparatus for measuring myocardial wall thickness in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) a piezoelectric substrate layer having first and second surfaces; (d) first and second concentric electrode layers adjacent to said first surface of said substrate; and (e) a third electrode layer adjacent to said second surface of said substrate; (f) wherein said first and second concentric electrode layers are spaced apart from said third electrode layer, and wherein said first and second electrode layers are separated by an annular groove extending between said first and second electrode layers and said first surface of said substrate; (g) said first electrode layer electrically coupled to said transmitting means, said second electrode layer electrically coupled to said receiving means, said third electrode layer electrically coupled to said transmitting means and said receiving means; (h) means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within said myocardium; (i) means for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (j) means for sampling signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (k) means for comparing sampled signal levels from said reference volume and said interface volume at successive time intervals.
Claim 15
Dependent Claim
277 words
A sonomicrometer apparatus for measuring myocardial wall thickness in a heart, comprising: (a) transmitting means for transmitting an ultrasonic signal; (b) receiving means for receiving an ultrasonic signal which is a reflection of said transmitted ultrasonic signal; (c) a piezoelectric substrate layer having first and second surfaces; (d) first and second concentric electrode layers adjacent to said first surface of said substrate; and (e) a third electrode layer adjacent to said second surface of said substrate; (f) wherein said first and second concentric electrode layers are spaced apart from said third electrode layer, and wherein said first and second electrode layers are separated by an annular groove extending between said first and second electrode layers and said first surface of said substrate; (g) said first electrode layer electrically coupled to said transmitting means, said second electrode layer electrically coupled to said receiving means, said third electrode layer electrically coupled to said transmitting means and said receiving means; (h) means for acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within said myocardium; (i) means for acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (j) means for sampling signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (k) means for comparing sampled signal levels from said reference volume and said interface volume at successive time intervals.
Claim 16
Independent Claim
152 words
A method for measuring the thickness of the myocardial wall in a heart, comprising the steps of: (a) subjecting the heart to a transmitted signal comprising ultrasonic pulses; (b) receiving an ultrasonic signal which is a reflection of said transmitted signal from the heart; (c) acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (d) acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (e) comparing signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (f) generating an output signal indicative of a differential in said signal levels.
Claim 17
Independent Claim
152 words
A method for measuring the thickness of the myocardial wall in a heart, comprising the steps of: (a) subjecting the heart to a transmitted signal comprising ultrasonic pulses; (b) receiving an ultrasonic signal which is a reflection of said transmitted signal from the heart; (c) acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (d) acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to spatially position an interface volume at the endocardial muscle/blood interface; (e) comparing signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; and (f) generating an output signal indicative of a differential in said signal levels.
Claim 18
Dependent Claim
32 words
A method as recited in claim 13, further comprising the steps of adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface of said heart.
Claim 19
Dependent Claim
27 words
A method as recited in claim 13, further comprising the steps of integrating the differential in signal levels throughout the cardiac cycle to determine myocardial wall thickness.
Claim 20
Independent Claim
191 words
A method for measuring absolute myocardial wall thickness in a heart, comprising the steps of: (a) subjecting the heart to a transmitted signal comprising ultrasonic pulses; (b) receiving an ultrasonic signal which is a reflection of said transmitted signal from the heart; (c) acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (d) acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to position an interface volume at the endocardial muscle/blood interface of the heart; (e) adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface of said heart; (f) comparing the RMS signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; (g) generating an output signal indicative of a differential in said signal levels; and (h) integrating the differential in signal levels throughout the cardiac cycle to determine myocardial wall thickness.
Claim 21
Independent Claim
191 words
A method for measuring absolute myocardial wall thickness in a heart, comprising the steps of: (a) subjecting the heart to a transmitted signal comprising ultrasonic pulses; (b) receiving an ultrasonic signal which is a reflection of said transmitted signal from the heart; (c) acquiring a reflected signal from a first volumetric region within the myocardium of the heart so as to spatially position a reference volume within the myocardium; (d) acquiring a reflected signal from a second volumetric region wherein one-half of said second volumetric region is within said myocardium and one-half of said second volumetric region is within the adjacent ventricular chamber so as to position an interface volume at the endocardial muscle/blood interface of the heart; (e) adjusting the positions of said reference volume and said interface volume to track the endocardial muscle/blood interface of said heart; (f) comparing the RMS signal levels from said reference volume and said interface volume at successive time intervals during a cardiac cycle; (g) generating an output signal indicative of a differential in said signal levels; and (h) integrating the differential in signal levels throughout the cardiac cycle to determine myocardial wall thickness.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-13 | 2000-02-12 | 2000-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-13 | 2004-02-12 | 2004-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-13 | 2008-02-12 | 2008-08-13 | $7700.00 | Window Closed / Lapsed |