US5540737A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Minimally invasive monopole phased array hyperthermia applicators and method for treating breast carcinomas
Assignee: Massachusetts Institute of Technology
•
Filing: 1993-11-24
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Granted: 1996-07-30
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Expires: 2013-11-24
Abstract
Abstract An RF hyperthermia applicator for inducing a temperature rise in a human female breast for treating carcinomas includes a waveguide applicator having an aperture and a phased-array of monopole electric field radiators coupled to a source of electric field energy for producing electric field radiation output from the waveguide through the aperture. Compression means is used for compressing a human breast to a predetermined thickness. The waveguide is positioned adjacent to the compression means such that the breast is positioned adjacent to the aperture and thereby receives electric field radiation from the waveguide. In another embodiment, at least two waveguide applicators are positioned on opposite sides of the compression means so that the compressed breast is positioned between the opposed apertures of the waveguides. An electric field probe is placed into a target within the breast to assist in focusing the electric field energy into the target.
Inventors
- 👤 Alan J. Fenn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:52
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/02; A61N5/04
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
88 words
A hyperthermia applicator for inducing a temperature rise in a human breast, comprising a source of electric field energy; a waveguide comprising an aperture and an electric field radiator disposed within said waveguide and coupled to the source of electric field energy for producing electric field radiation output from the waveguide through the aperture; and compression means for compressing a human breast to a predetermined thickness, the waveguide being adapted to be disposed such that the compressed breast is positioned to receive electric field radiation from the waveguide.
Claim 2
Dependent Claim
88 words
A hyperthermia applicator for inducing a temperature rise in a human breast, comprising a source of electric field energy; a waveguide comprising an aperture and an electric field radiator disposed within said waveguide and coupled to the source of electric field energy for producing electric field radiation output from the waveguide through the aperture; and compression means for compressing a human breast to a predetermined thickness, the waveguide being adapted to be disposed such that the compressed breast is positioned to receive electric field radiation from the waveguide.
Claim 3
Dependent Claim
18 words
The apparatus of claim 1, wherein the electric field radiator comprises a phased-array of electric field transmit elements.
Claim 4
Dependent Claim
20 words
The apparatus of claim 2, wherein the phased-array of electric field transmit elements comprises an array of monopole antenna elements.
Claim 5
Dependent Claim
107 words
The apparatus of claim 3, wherein the waveguide comprises a first RF reflecting groundplane surface for mounting the monopole antenna elements, wherein the monopole antenna elements are perpendicularly mounted to the first RF reflecting groundplane surface, a second RF reflecting groundplane surface disposed substantially parallel to the first RF reflecting groundplane surface such that the monopole antenna elements are positioned between the first and second RF reflecting groundplane surfaces; and an RF reflecting screen mounted substantially perpendicular to the first and second RF reflecting groundplane surfaces and behind the monopole antenna elements to reflect RF energy from the monopole antenna elements toward the aperture of the waveguide.
Claim 6
Dependent Claim
22 words
The apparatus of claim 4 wherein the RF reflecting screen is positioned between 1/8 to 1/2 wavelength from the monopole antenna elements.
Claim 7
Dependent Claim
33 words
The apparatus of claim 4 wherein the waveguide comprises an enclosure surrounding the monopole antenna elements providing a vessel for enclosing a bolus of fluid between the monopole antenna elements and the breast.
Claim 8
Dependent Claim
14 words
The apparatus of claim 6 wherein the vessel comprises a bolus of deionized water.
Claim 9
Dependent Claim
20 words
The apparatus of claim 3 wherein the monopole antenna elements are arranged along a circular arc of substantially constant radius.
Claim 10
Dependent Claim
51 words
The apparatus of claim 8 wherein the compression means comprises a plurality of compression surfaces for compressing the breast between the compression surfaces, and the radius of the circular arc of monopole antenna elements is substantially the distance from the monopole antenna array to a compression surface adjacent an internal target.
Claim 11
Dependent Claim
51 words
The apparatus of claim 8 wherein the compression means comprises a plurality of compression surfaces for compressing the breast between the surfaces, and the radius of the circular arc of monopole antenna elements is substantially the distance from the monopole antenna array to a target position located between the compression surfaces.
Claim 12
Dependent Claim
17 words
The apparatus of claim 3 wherein the monopole antenna elements resonate at between 800 and 1000 MHz.
Claim 13
Dependent Claim
92 words
The apparatus of claim 2 further comprising at least one electric field probe for detecting electric field radiation; and a controller coupled to the electric field probe for receiving the detected electric field radiation and generating a respective feedback signal and coupled to the source of electric field energy for controlling the source of electric field energy applied to each phased-array antenna transmit element, and for adjusting the feedback signal in response to the detected electric field radiation so that the detected electric field radiation is maximized at the electric field probe.
Claim 14
Dependent Claim
33 words
The apparatus of claim 12, wherein the electric field probe comprises at least one probe element adapted to be disposed invasively within the breast at a desired focus of the electric field energy.
Claim 15
Dependent Claim
17 words
The apparatus of claim 13, further comprising mammography means for imaging the internal structure of the breast.
Claim 16
Dependent Claim
147 words
A hyperthermia applicator for inducing a temperature rise in a human breast, comprising a source of electric field energy; a first waveguide comprising a first aperture and a first electric field radiator disposed within the first waveguide and coupled to the source of electric field energy for producing electric field radiation output from the first waveguide through the first aperture; a second waveguide comprising a second aperture and a second electric field radiator disposed within the second waveguide and coupled to the source of electric field energy for producing electric field radiation output from the second waveguide through the second aperture; compression means for compressing a human breast to a predetermined thickness, the first and second waveguides being adapted to be disposed on opposite sides of the compression means such that the compressed breast is positioned to receive electric field radiation from the first and second waveguides.
Claim 17
Dependent Claim
147 words
A hyperthermia applicator for inducing a temperature rise in a human breast, comprising a source of electric field energy; a first waveguide comprising a first aperture and a first electric field radiator disposed within the first waveguide and coupled to the source of electric field energy for producing electric field radiation output from the first waveguide through the first aperture; a second waveguide comprising a second aperture and a second electric field radiator disposed within the second waveguide and coupled to the source of electric field energy for producing electric field radiation output from the second waveguide through the second aperture; compression means for compressing a human breast to a predetermined thickness, the first and second waveguides being adapted to be disposed on opposite sides of the compression means such that the compressed breast is positioned to receive electric field radiation from the first and second waveguides.
Claim 18
Dependent Claim
22 words
The apparatus of claim 15, wherein the first and second electric field radiators each comprise a phased-array of electric field transmit elements.
Claim 19
Dependent Claim
20 words
The apparatus of claim 16, wherein the phased-array of electric field transmit elements comprises an array of monopole antenna elements.
Claim 20
Dependent Claim
111 words
The apparatus of claim 17, wherein the first and second waveguides each comprise a first RF reflecting groundplane surface for mounting the monopole antenna elements, wherein the monopole antenna elements are perpendicularly mounted to the first RF reflecting groundplane surface, a second RF reflecting groundplane surface disposed substantially parallel to the first RF reflecting groundplane surface such that the monopole antenna elements are positioned between the first and second RF reflecting groundplane surfaces, and an RF reflecting screen mounted substantially perpendicular to the first and second RF reflecting groundplane surfaces behind the monopole antenna elements to reflect RF energy from the monopole antenna elements toward the aperture of the corresponding waveguide.
Claim 21
Dependent Claim
22 words
The apparatus of claim 18 wherein the RF reflecting screen is positioned between 1/8 to 1/2 wavelength from the monopole antenna elements.
Claim 22
Dependent Claim
37 words
The apparatus of claim 18 wherein said first and second waveguides each comprise an enclosure surrounding the monopole antenna elements providing a vessel for enclosing a bolus of fluid between the monopole antenna elements and the breast.
Claim 23
Dependent Claim
14 words
The apparatus of claim 20 wherein the vessel comprises a bolus of deionized water.
Claim 24
Dependent Claim
20 words
The apparatus of claim 17 wherein the monopole antenna elements are arranged along a circular arc of substantially constant radius.
Claim 25
Dependent Claim
51 words
The apparatus of claim 22 wherein the compression means comprises a plurality of compression surfaces for compressing the breast between the compression surfaces, and the radius of the circular arc of monopole antenna elements is substantially the distance from the monopole antenna array to a compression surface adjacent an internal target.
Claim 26
Dependent Claim
51 words
The apparatus of claim 22 wherein the compression means comprises a plurality of compression surfaces for compressing the breast between the surfaces, and the radius of the circular arc of monopole antenna elements is substantially the distance from the monopole antenna array to a target position located between the compression surfaces.
Claim 27
Dependent Claim
17 words
The apparatus of claim 17 wherein the monopole antenna elements resonate at between 800 and 1000 MHz.
Claim 28
Independent Claim
92 words
The apparatus of claims 16 further comprising at least one electric field probe for detecting electric field radiation; and a controller coupled to the electric field probe for receiving the detected electric field radiation and generating a respective feedback signal and coupled to the source of electric field energy for controlling the source of electric field energy applied to each phased-array antenna transmit element, and for adjusting the feedback signal in response to the detected electric field radiation so that the detected electric field radiation is maximized at the electric field probe.
Claim 29
Dependent Claim
33 words
The apparatus of claim 26, wherein the electric field probe comprises at least one probe element adapted to be disposed invasively within the breast at a desired focus of the electric field energy.
Claim 30
Dependent Claim
17 words
The apparatus of claim 27, further comprising mammography means for imaging the internal structure of the breast.
Claim 31
Independent Claim
83 words
A method for inducing a temperature rise in a human breast, comprising the steps of: compressing a human breast to a predetermined thickness; positioning adjacent the breast a waveguide comprising an aperture and an electric field radiator disposed within the waveguide and coupled to a source of electric field energy for producing electric field radiation output from the waveguide through the aperture; irradiating the breast with electric field radiation output from the waveguide aperture to raise the internal temperature of the breast tissue.
Claim 32
Independent Claim
83 words
A method for inducing a temperature rise in a human breast, comprising the steps of: compressing a human breast to a predetermined thickness; positioning adjacent the breast a waveguide comprising an aperture and an electric field radiator disposed within the waveguide and coupled to a source of electric field energy for producing electric field radiation output from the waveguide through the aperture; irradiating the breast with electric field radiation output from the waveguide aperture to raise the internal temperature of the breast tissue.
Claim 33
Dependent Claim
83 words
The method of claim 29, further comprising the steps of: inserting an electric field probe, for detecting electric field radiation, into the breast at the desired focus of the electric field energy; detecting the electric field radiation with the electric field probe; and generating a feedback signal for controlling the source of electric field energy applied to the electric field radiator in response to the detected electric field radiation so that the detected electric field radiation is maximized at the electric field probe.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-30 | 2000-01-29 | 2000-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-30 | 2004-01-29 | 2004-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-30 | 2008-01-29 | 2008-07-30 | $7700.00 | Window Closed / Lapsed |