US5532305A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release preparation for bioactive substances
Assignee: Shiseido Co Ltd
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Filing: 1994-07-26
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Granted: 1996-07-02
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Expires: 2014-07-26
Abstract
Abstract To provide a base suitable for a controlled release preparation and the controlled release preparation. A bioactive substance(s) is introduced in a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid derivative(s).
Inventors
- 👤 Fumiaki Matsuzaki
- 👤 Toshio Yanaki
- 👤 Michihiro Yamaguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/205; A61P; A61P11/00; A61P11/14; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
28 words
A composition comprising a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid copolymer having the formula: ##STR3## wherein R=CH 3 or C 4 H 9 .
Claim 2
Dependent Claim
28 words
A composition comprising a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid copolymer having the formula: ##STR3## wherein R=CH 3 or C 4 H 9 .
Claim 3
Dependent Claim
12 words
A carrier for a bioactive substance comprising the composition of claim 1.
Claim 4
Dependent Claim
18 words
A controlled release preparation comprising a bioactive substance and a Carrier therefor of the composition of claim 1.
Claim 5
Dependent Claim
13 words
The controlled release preparation of claim 3, wherein the bioactive substance is noscapine-HCl.
Claim 6
Dependent Claim
13 words
The controlled release preparation of claim 3, wherein the bioactive substance is indomethacin.
Claim 7
Dependent Claim
16 words
The composition of claim 1, wherein the copolymer has a mean molecular weight of about 150,000.
Claim 8
Dependent Claim
20 words
A carrier for a bioactive substance of claim 2, wherein the copolymer has a mean molecular weight of about 150,000.
Claim 9
Dependent Claim
32 words
A controlled release preparation of claim 3, wherein said bioactive substance is selected from the group consisting of noscapine-HCl and indomethacin, and the copolymer has a mean molecular weight of about 150,000.
Claim 10
Dependent Claim
22 words
A controlled release preparation of claim 3, wherein the bioactive substance is present in an amount of from about 0.01-50 wt. %.
Claim 11
Dependent Claim
57 words
A composition comprising a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid copolymer having the formula: ##STR4## wherein R 1 is H or CH 3 and R 2 is CH 3 or C 2 H 5 . and wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
Claim 12
Dependent Claim
57 words
A composition comprising a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid copolymer having the formula: ##STR4## wherein R 1 is H or CH 3 and R 2 is CH 3 or C 2 H 5 . and wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
Claim 13
Dependent Claim
12 words
A carrier for a bioactive substance comprising the composition of claim 10.
Claim 14
Dependent Claim
18 words
A controlled release preparation comprising a bioactive substance and a carrier therefor of the composition of claim 10.
Claim 15
Dependent Claim
13 words
The controlled release preparation of claim 12, wherein the bioactive substance is noscapine-HCl.
Claim 16
Dependent Claim
13 words
The controlled release preparation of claim 12, wherein the bioactive substance is indomethacin.
Claim 17
Dependent Claim
16 words
The composition of claim 10, wherein the copolymer has a mean molecular weight of about 150,000.
Claim 18
Dependent Claim
20 words
A carrier for a bioactive substance of claim 11, wherein the copolymer has a mean molecular weight of about 150,000.
Claim 19
Dependent Claim
32 words
A controlled release preparation of claim 10, wherein said bioactive substance is selected from the group consisting of noscapine-HCl and indomethacin, and the copolymer has a mean molecular weight of about 150,000.
Claim 20
Dependent Claim
22 words
A controlled release preparation of claim 12, wherein the bioactive substance is present in an amount of from about 0.01-50 wt. %.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-02 | 2000-01-01 | 2000-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-02 | 2004-01-01 | 2004-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-02 | 2008-01-01 | 2008-07-02 | $7700.00 | Window Closed / Lapsed |