US5530001A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical use of dihydropyridine derivative
Assignee: Tanabe Pharma Corp
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Filing: 1994-03-22
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Granted: 1996-06-25
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Expires: 2014-03-22
Abstract
Abstract A novel pharmaceutical use of a dihydropyridine derivative of the formula (I) ##STR1## wherein R 1 , R 2 and R 3 are the same or different and each is an alkyl or the like; R 4 is a hydrogen atom or the like; R 5 is nitro, a halogenated alkyl, cyano or the like; X is a vinylene or an azomethine; A is an alkylene; and B is --N(R 6 ) (R 7 ) or a group of the formula ##STR2## wherein R 6 and R 7 are the same or different and each is an alkyl, an aralkyl, an aryl or the like; R 8 and Ar are aryl or the like; and n is 0, 1 or 2, or an acid addition salt thereof for promoting PGI 2 production, and for the treatment and prevention of hyperlipemia, arteriosclerosis and cerebral diseases.
Inventors
- 👤 Masahide Nakajima
- 👤 Norifumi Nakamura
- 👤 Feng Wang
- 👤 Koichi Yamanouchi
- 👤 Kazutaka Hayashi
- 👤 Hideaki Kido
- 👤 Yoshiji Kubo
- 👤 Minori Okita
- 👤 Takeshi Uchida
- 👤 Masahiro Watanabe
- 👤 Katsumi Yamanaga
- 👤 Hiroshi Shinyama
- 👤 Toru Kawamura
- 👤 Yuji Narita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/455; A61K31/495
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
195 words
A method for promoting PGI 2 production, and for the treatment of hyperlipemia, arteriosclerosis, cerebral edema, cerebral softening or cerebral hemorrhage, comprising administrating an effective amount of the diyhydropyridine derivative of the formula (I) ##STR6## wherein R 1 , R 2 and R 3 are the same or different and each is an alkyl, a cycloalkyl or an alkoxyalkyl; R 4 and R 5 are the same or different and each is a hydrogen atom, a halogen, nitro, a halogenated alkyl, an alkylsulfonyl, a halogenated alkoxy, an alkylsulfinyl, an alkyl, a cycloalkyl, an alkoxy, cyano, an alkoxycarbonyl or an alkylthio, provided that R 4 and R 5 are not hydrogen atoms at the same time; X is a vinylene or an azomethine; A is an alkylene; and B is --N(R 6 )(R 7 ) or a group of the formula ##STR7## wherein R 6 , R 7 and R 8 are the same or different and each is a hydrogen atom, an alkyl, a cycloalkyl, an aralkyl, an aryl or a pyridyl, Ar is an aryl or a pyridyl and n is an integer of 0, 1 or 2; or an acid addition salt thereof.
Claim 2
Independent Claim
195 words
A method for promoting PGI 2 production, and for the treatment of hyperlipemia, arteriosclerosis, cerebral edema, cerebral softening or cerebral hemorrhage, comprising administrating an effective amount of the diyhydropyridine derivative of the formula (I) ##STR6## wherein R 1 , R 2 and R 3 are the same or different and each is an alkyl, a cycloalkyl or an alkoxyalkyl; R 4 and R 5 are the same or different and each is a hydrogen atom, a halogen, nitro, a halogenated alkyl, an alkylsulfonyl, a halogenated alkoxy, an alkylsulfinyl, an alkyl, a cycloalkyl, an alkoxy, cyano, an alkoxycarbonyl or an alkylthio, provided that R 4 and R 5 are not hydrogen atoms at the same time; X is a vinylene or an azomethine; A is an alkylene; and B is --N(R 6 )(R 7 ) or a group of the formula ##STR7## wherein R 6 , R 7 and R 8 are the same or different and each is a hydrogen atom, an alkyl, a cycloalkyl, an aralkyl, an aryl or a pyridyl, Ar is an aryl or a pyridyl and n is an integer of 0, 1 or 2; or an acid addition salt thereof.
Claim 3
Dependent Claim
72 words
The method of claim 1, wherein R 1 , R 2 and R 3 are the same or different and each is an alkyl, R 4 is a hydrogen atom, R 5 is nitro, a halogenated alkyl or cyano, R 6 and R 7 are the same or different and each is an alkyl, an aralkyl or an aryl, R 8 is an aryl, Ar is an aryl and n is 1.
Claim 4
Dependent Claim
13 words
The method of claim 1, which is used for promoting PGI 2 production.
Claim 5
Dependent Claim
13 words
The method of claim 1, which is used for the treatment of hyperlipemia.
Claim 6
Dependent Claim
13 words
The method of claim 1, which is used for the treatment of arteriosclerosis.
Claim 7
Dependent Claim
19 words
The method of claim 1, which is used for the treatment of cerebral edema, cerebral softening or cerebral hemorrhage.
References Cited (Backward Citations)
US4886819A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-25 | 1999-12-25 | 2000-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-25 | 2003-12-25 | 2004-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-25 | 2007-12-25 | 2008-06-25 | $7700.00 | Window Closed / Lapsed |