US5457116A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of inhibiting uterine fibrosis
Assignee: Eli Lilly and Co
•
Filing: 1993-10-15
•
Granted: 1995-10-10
•
Expires: 2013-10-15
Abstract
Abstract A method of inhibiting uterine fibrosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula <IMAGE> (I) Wherein R1 and R3 are independently hydrogen, <IMAGE> wherein Ar is optionally substituted phenyl; wherein R2 is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof.
Inventors
- 👤 Larry J. Black
- 👤 George J. Cullinan
- 👤 Michael W. Draper
- 👤 Charles D. Jones
- 👤 David E. Seyler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:06
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K31/4523; A61K31/4535; A61K31/38; A61K31/40; A61K31/4025; A61P; A61P13/00; A61P13/02; A61P15/00; A61P15/02; C; C07; C07D; C07D409/00; C07D409/02; C07D409/10
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
64 words
A method of inhibiting uterine fibrosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR5## Wherein R 1 and R 3 are independently hydrogen, ##STR6## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
Claim 2
Independent Claim
64 words
A method of inhibiting uterine fibrosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR5## Wherein R 1 and R 3 are independently hydrogen, ##STR6## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein said compound is the hydrochloride salt thereof.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein said compound is ##STR7## or its hydrochloride salt.
Claim 5
Dependent Claim
19 words
The method according to claim 1 wherein said human or other mammal is also administered gonadotropin releasing hormone antagonist.
References Cited (Backward Citations)
US4133814A
Cited
US4380635A
Cited
US4418068A
Cited
US5075321A
Cited
WO1993001074A1
Cited
WO1993010113A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-09 | 1999-04-10 | 1999-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-09 | 2003-04-10 | 2003-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-09 | 2007-04-10 | 2007-10-10 | $7700.00 | Window Closed / Lapsed |