US5457113A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
Assignee: Eli Lilly and Co
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Filing: 1993-10-15
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Granted: 1995-10-10
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Expires: 2013-10-15
Abstract
Abstract Methods of inhibiting vascular smooth muscle cell proliferation and vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula <IMAGE> (I) or <IMAGE> (II) wherein R1 and R3 are independently hydrogen, -CH3, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is <IMAGE> R4 is hydrogen or -OR1, and pharmaceutically acceptable salts and solvates thereof.
Inventors
- 👤 George J. Cullinan
- 👤 Jai P. Singh
- 👤 Dan L. Wood
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/4025; A61K31/38; A61K31/435; A61K31/44; A61K31/445; A61K31/4453; A61K31/4523; A61K31/4535; A61K31/55; A61P; A61P9/00; A61P9/10; A61P9/14
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
66 words
A method of inhibiting vascular smooth muscle cell proliferation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR8## wherein R 1 and R 3 are independently hydrogen, --CH 3 , ##STR9## wherein Ar is optionally substituted phenyl; ##STR10## R 4 is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof.
Claim 2
Independent Claim
66 words
A method of inhibiting vascular smooth muscle cell proliferation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR8## wherein R 1 and R 3 are independently hydrogen, --CH 3 , ##STR9## wherein Ar is optionally substituted phenyl; ##STR10## R 4 is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein said compound is the hydrochloride salt thereof.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein said administration is prophylactic.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein said compound is ##STR11## or its hydrochloride salt.
Claim 6
Independent Claim
67 words
A method of inhibiting vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR12## wherein R 1 and R 3 are independently hydrogen, --CH 3 , ##STR13## wherein Ar is optionally substituted phenyl; R 2 is ##STR14## and R 4 is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof.
Claim 7
Independent Claim
67 words
A method of inhibiting vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR12## wherein R 1 and R 3 are independently hydrogen, --CH 3 , ##STR13## wherein Ar is optionally substituted phenyl; R 2 is ##STR14## and R 4 is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof.
Claim 8
Dependent Claim
13 words
The method of claim 5 wherein said compound is the hydrochloride salt thereof.
Claim 9
Dependent Claim
10 words
The method of claim 5 wherein said administration is prophylactic.
Claim 10
Dependent Claim
14 words
The method of claim 5 wherein said compound is ##STR15## or its hydrochloride salt.
References Cited (Backward Citations)
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Cited
US4380635A
Cited
US4418068A
Cited
US5075321A
Cited
WO1993001074A1
Cited
WO1993010113A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-09 | 1999-04-10 | 1999-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-09 | 2003-04-10 | 2003-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-09 | 2007-04-10 | 2007-10-10 | $7700.00 | Window Closed / Lapsed |