US5433745A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Corneal implants and methods for producing same
Assignee: Johnson and Johnson Surgical Vision Inc
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Filing: 1993-10-13
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Granted: 1995-07-18
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Expires: 2013-10-13
Abstract
Abstract New corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on the outer surface, covalently bonded to the hydrogel composition and having enhanced ability to support epithelial cell growth and/or adhesion relative to the hydrogel composition.
Inventors
- 👤 Richard S. Graham
- 👤 Crystal M. Cunanan
- 👤 James E. Francese
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:58
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/145; A61F2/142
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
104 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, said synthetic polymeric material has increased hydrophobicity relative to said hydrophilic polymeric material.
Claim 2
Dependent Claim
104 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, said synthetic polymeric material has increased hydrophobicity relative to said hydrophilic polymeric material.
Claim 3
Dependent Claim
19 words
The corneal implant of claim 1 wherein said hydrogel composition includes at least about 60% by weight of water.
Claim 4
Dependent Claim
20 words
The corneal implant of claim 1 wherein said coating is sufficiently thin so as to remain substantially free of cracks.
Claim 5
Dependent Claim
16 words
The corneal implant of claim 1 wherein said coating is less than about 0.3 micron thick.
Claim 6
Dependent Claim
45 words
The corneal implant of claim 1 wherein said lens body further comprises a cytophilic component located on said coating and being present in an amount effective to enhance the initial cytophilicity of said lens body relative to an identical lens body without said cytophilic component.
Claim 7
Dependent Claim
14 words
The corneal implant of claim 5 wherein said cytophilic component comprises a collagen-containing component.
Claim 8
Dependent Claim
24 words
The corneal implant of claim 5 wherein said cytophilic component is covalently bonded to at least one of said hydrogel composition and said coating.
Claim 9
Dependent Claim
23 words
The corneal implant of claim 1 wherein said lens body is structured to be surgically attached on the cornea of a mammalian eye.
Claim 10
Dependent Claim
119 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, a coating located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, and a cytophilic component located on said coating and being present in an amount effective to enhance the initial cytophilicity of said lens body relative to an identical lens body without said cytophilic component.
Claim 11
Dependent Claim
119 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, a coating located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, and a cytophilic component located on said coating and being present in an amount effective to enhance the initial cytophilicity of said lens body relative to an identical lens body without said cytophilic component.
Claim 12
Dependent Claim
14 words
The corneal implant of claim 9 wherein said cytophilic component comprises a collagen-containing component.
Claim 13
Dependent Claim
24 words
The corneal implant of claim 9 wherein said cytophilic component is covalently bonded to at least one of said hydrogel composition and said coating.
Claim 14
Dependent Claim
81 words
A composition useful as a corneal implant comprising a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric component and a coating comprising a synthetic polymeric material located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, said synthetic polymeric material having increased hydrophobicity relative to said hydrophilic polymeric material.
Claim 15
Dependent Claim
81 words
A composition useful as a corneal implant comprising a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric component and a coating comprising a synthetic polymeric material located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition, said synthetic polymeric material having increased hydrophobicity relative to said hydrophilic polymeric material.
Claim 16
Dependent Claim
28 words
The composition of claim 12 wherein said hydrogel composition includes at least about 60% by weight of water, and said coating is less than about 0.3 micron thick.
Claim 17
Dependent Claim
39 words
The composition of claim 12 which further comprises a cytophilic component located on said coating and being present in an amount effective to enhance the initial cytophilicity of said composition relative to an identical composition without said cytophilic component.
Claim 18
Dependent Claim
98 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating less than about 0.3 micron thick which comprises a synthetic polymeric component located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition.
Claim 19
Dependent Claim
98 words
A corneal implant comprising a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, said lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating less than about 0.3 micron thick which comprises a synthetic polymeric component located on said outer surface, covalently bonded to said hydrogel composition and having enhanced ability to support at least one of epithelial cell growth and epithelial cell adhesion relative to said hydrogel composition.
Claim 20
Dependent Claim
19 words
The corneal implant of claim 15 wherein said hydrogel composition includes at least about 60% by weight of water.
Claim 21
Dependent Claim
20 words
The corneal implant of claim 15 wherein said coating is sufficiently thin so as to remain substantially free of cracks.
Claim 22
Dependent Claim
45 words
The corneal implant of claim 15 wherein said lens body further comprises a cytophilic component located on said coating and being present in an amount effective to enhance the initial cytophilicity of said lens body relative to an identical lens body without said cytophilic component.
Claim 23
Dependent Claim
14 words
The corneal implant of claim 18 wherein said cytophilic component comprises a collagen-containing component.
Claim 24
Dependent Claim
24 words
The corneal implant of claim 18 wherein said cytophilic component is covalently bonded to at least one of said hydrogel composition and said coating.
Claim 25
Dependent Claim
23 words
The corneal implant of claim 15 wherein said lens body is structured to be surgically attached on the cornea of a mammalian eye.
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