Patent US1946894A successfully refreshed from Google Patents.
US5420176A
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US
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Contrast media for ultrasonic imaging
Assignee: ImaRx Therapeutics Inc
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Filing: 1993-05-05
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Granted: 1995-05-30
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Expires: 2013-05-05
Abstract
Abstract Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media may be employed, if desired, with anti-gas agents and/or suspending agents.
Inventors
- 👤 Evan C. Unger
- 👤 Guanli Wu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:20
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/226; A61K49/223
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
33 words
A contrast medium for ultrasonic imaging comprising an aqueous suspension of at least one biocompatible polymer which is cellulose or a modified cellulose polymer, wherein said polymer is coated with an α-(trimethylsilyl)-ω-methylpoly(oxy(dimethylsilylene)) compound.
Claim 2
Dependent Claim
33 words
A contrast medium for ultrasonic imaging comprising an aqueous suspension of at least one biocompatible polymer which is cellulose or a modified cellulose polymer, wherein said polymer is coated with an α-(trimethylsilyl)-ω-methylpoly(oxy(dimethylsilylene)) compound.
Claim 3
Dependent Claim
11 words
A contrast medium of claim 1 wherein the polymer is cellulose.
Claim 4
Dependent Claim
14 words
A contrast medium of claim 1 wherein the polymer is a modified cellulose polymer.
Claim 5
Dependent Claim
30 words
A contrast medium of claim 1 wherein the cellulose or modified cellulose polymer is selected from the group consisting of cellulose, carboxymethylcellulose, hydroxymethyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, and methoxycellulose.
Claim 6
Dependent Claim
15 words
A contrast medium of claim 1 wherein the polymer has a high water binding capacity.
Claim 7
Dependent Claim
11 words
A contrast medium of claim 1 further comprising an anti-gas agent.
Claim 8
Dependent Claim
77 words
A contrast medium of claim 6 wherein the anti-gas agent is selected from the group consisting of activated charcoal, aluminum carbonate, aluminum hydroxide, aluminum phosphate, calcium carbonate, dihydroxyaluminum sodium carbonate, magaldrate, magnesium oxide, magnesium trisilicate, sodium carbonate, loperamide hydrochloride, diphenoxylate, hydrochloride with atropine sulfate, kaolin, bismuth salts, polyoxypropylene-polyoxyethylene copolymers, polyoxyalkylene amines and imines, branched polyamines, mixed oxyalkylated alcohols, sucroglycamides, polyoxylalkylated natural oils, lauryl sulfates, 2-lactylic acid esters of unicarboxylic acids, triglyceride oils, and finely-divided polyvinyl chloride particles.
Claim 9
Dependent Claim
22 words
A contrast medium of claim 7 wherein the anti-gas agent is selected from the group consisting of activated charcoal and lauryl sulfate.
Claim 10
Dependent Claim
11 words
A contrast medium of claim 1 further comprising a suspending agent.
Claim 11
Dependent Claim
72 words
A contrast medium of claim 9 wherein the suspending agent is selected from the group consisting of xanthum gum, acacia, agar, alginic acid, aluminum monostearate, unpurified bentonits, purified bentonits, bentonits magma, carboxymethylcellulose calcium, carboxymethylcellulose sodium, carrageenan, cellulose (microcrystalline), carboxymethylcellulose sodium, dextrin, gelatin, guar gum, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium aluminum silicate, methylcellulose, pectin, polyethylene oxide, polyvinyl alcohol, povidone, propylene glycol alginate, silicon dioxide, silicon dioxide colloidal, sodium alginate, and tragacanth.
Claim 12
Dependent Claim
17 words
A contrast medium of claim 1 further comprising an α-(trimethylsilyl)-ω-methylpoly(oxy(dimethylsilylene)) compound in admixture with said coated polymer.
Claim 13
Dependent Claim
12 words
A contrast medium of claim 1 wherein the aqueous suspension is degassed.
Claim 14
Dependent Claim
14 words
A contrast medium of claim 12 wherein the contrast medium is stored under vacuum.
Claim 15
Dependent Claim
79 words
A contrast medium of claim 1 wherein the polymer comprises 0.5% by weight of an 18μ fiber length cellulose polymer; and wherein the cellulose polymer is coated with 0.25% by weight of an α-(trimethylsilyl)-ω-methylpoly(oxy(dimethylsilylene)) compound and is admixed with 500 ppm of an α-(trimethylsilyl)-ω-methylpoly(oxy(dimethylsilylene)) compound; and further comprising an anti-gas agent comprising lauryl sulfate and a suspending agent comprising 0.3% by weight xanthan gum; and wherein the aqueous suspension is degassed and the contrast medium is stored under vacuum.
Claim 16
Dependent Claim
21 words
A contrast medium of claim 1 which is a contrast medium for use in imaging a gastrointestinal region of a patent.
Claim 17
Dependent Claim
18 words
A contrast medium of claim 1 which is a contrast medium for use in imaging a body cavity.
Claim 18
Dependent Claim
11 words
A contrast medium of claim 11 wherein the polymer comprises cellulose.
Claim 19
Dependent Claim
17 words
A contrast medium of claim 17 wherein the cellulose polymer comprises about 18μ fiber length cellulose polymer.
Claim 20
Dependent Claim
23 words
A contrast medium of claim 18 wherein the cellulose polymer comprises between about 0.5% and about 1.0% by weight of the contrast medium.
Claim 21
Dependent Claim
25 words
A contrast medium of claim 19 further comprising xanthan gum and a compound selected from the group consisting of lauryl sulfate and a polyoxyethylene compound.
Claim 22
Dependent Claim
12 words
A contrast medium of claim 20 wherein the compound is lauryl sulfate.
Claim 23
Dependent Claim
20 words
A contrast medium of claim 20 wherein the aqueous solution is degassed and the contrast medium is stored under vacuum.
Claim 24
Dependent Claim
20 words
A contrast medium of claim 21 wherein the aqueous solution is degassed and the contrast medium is stored under vacuum.
Claim 25
Dependent Claim
17 words
A contrast medium of claim 20 wherein said contrast medium comprises about 0.3% by weight xanthan gum.
Claim 26
Dependent Claim
17 words
A contrast medium of claim 21 wherein said contrast medium comprises about 0.3% by weight xanthan gum.
Claim 27
Dependent Claim
16 words
A contrast medium of claim 1 wherein the polymer further comprises a coating of silicon dioxide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-05-29 | 1998-11-28 | 1999-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-29 | 2002-11-28 | 2003-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-29 | 2006-11-28 | 2007-05-30 | $7700.00 | Window Closed / Lapsed |