US5409457A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intraretinal delivery and withdrawal instruments
Assignee: University of Rochester
•
Filing: 1993-12-21
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Granted: 1995-04-25
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Expires: 2013-12-21
Abstract
Abstract An intraretinal delivery and withdrawal instrument which has (a) a curved, distal frame for insertion into an orbit, which insertion is effected (i) inferior to the supraorbital ridge, (ii) superior to the eye, and (iii) in a caudal direction so as to reach the retina; (b) a tip for penetration into the subretinal region of the eye connected to the frame; and (c) an adjustable collar connected to the tip which collar is capable of being positioned so that the collar regulates the depth of tip penetration into the subretinal region including methods for uses thereof.
Inventors
- 👤 Manuel del Cerro
- 👤 Eliot Lazar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:01
CPC Classifications
A; A61; A61F; A61F9/00; A61F9/007; A61F9/00736; A61M; A61M25/00; A61M25/0021; A61M2025/0042; A61M2210/00; A61M2210/06; A61M2210/0612
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
156 words
A method for grafting cells into an intraretinal eye area which comprises the steps of: inserting an intraocular delivery and withdrawal instrument into the retinal area of the eye, said instrument comprising an elongated handle having a distal end and a proximal end and shaped and dimensioned to be grasped by the hand of a user and an elongated curved frame extending from the distal end of the handle and having a proximal end; and a tip extending from said distal end of the frame; said frame and tip being shaped and dimensioned for insertion into an orbit in said insertion direction so as to place said tip adjacent to the retina and pointing in a direction for penetration into the intraocular region of the eye when said tip is moved generally in the medial direction; and transferring cells from the instrument into said retinal area to thereby graft the cells into the intraocular eye area.
Claim 2
Independent Claim
156 words
A method for grafting cells into an intraretinal eye area which comprises the steps of: inserting an intraocular delivery and withdrawal instrument into the retinal area of the eye, said instrument comprising an elongated handle having a distal end and a proximal end and shaped and dimensioned to be grasped by the hand of a user and an elongated curved frame extending from the distal end of the handle and having a proximal end; and a tip extending from said distal end of the frame; said frame and tip being shaped and dimensioned for insertion into an orbit in said insertion direction so as to place said tip adjacent to the retina and pointing in a direction for penetration into the intraocular region of the eye when said tip is moved generally in the medial direction; and transferring cells from the instrument into said retinal area to thereby graft the cells into the intraocular eye area.
Claim 3
Dependent Claim
50 words
A method for grafting cells into an intraretinal eye area as recited in claim 1, wherein said step of transferring cells comprises inserting the tip of said instrument into the tissues of the eye to a predetermined depth limited by the instrument and making a micro-injection into the retinal area.
Claim 4
Dependent Claim
32 words
A method for grafting cells into an intraretinal eye area as recited in claim 2, wherein the instrument is pre-set to dispense only a predetermined amount of cells at the predetermined depth.
Claim 5
Dependent Claim
30 words
A method for grafting cells into an intraretinal eye area as recited in claim 1, wherein said cells are injected at four points in different quadrants of the retinal area.
Claim 6
Dependent Claim
141 words
An instrument for grafting cells at a predetermined depth in an intraretinal eye area comprising: an elongated handle having a distal end and a proximal end and shaped and dimensioned to be grasped by the hand of a user; an elongated curved frame extending from the distal end of the handle and having a proximal end; a tip extending from said distal end of the frame, said tip and frame being shaped and dimensioned for insertion into an orbit along an insertion path around the periphery of the eye so as to place said tip adjacent to the retina and pointing in a direction for penetration into the intraocular region of the eye; and an adjustable collar secured to the instrument to limit the depth to which said tip penetrates into the intraocular area of the eye to said predetermined depth.
Claim 7
Dependent Claim
141 words
An instrument for grafting cells at a predetermined depth in an intraretinal eye area comprising: an elongated handle having a distal end and a proximal end and shaped and dimensioned to be grasped by the hand of a user; an elongated curved frame extending from the distal end of the handle and having a proximal end; a tip extending from said distal end of the frame, said tip and frame being shaped and dimensioned for insertion into an orbit along an insertion path around the periphery of the eye so as to place said tip adjacent to the retina and pointing in a direction for penetration into the intraocular region of the eye; and an adjustable collar secured to the instrument to limit the depth to which said tip penetrates into the intraocular area of the eye to said predetermined depth.
Claim 8
Dependent Claim
41 words
An instrument for grafting cells into an intraretinal eye area as recited in claim 5, in which said tip comprises a beveled tip of a curved needle, said needle being tightly sheathed in plastic with the beveled tip thereof left exposed.
Claim 9
Dependent Claim
32 words
An instrument for grafting cells into an intraretinal eye area as recited in claim 5, wherein the instrument is pre-set to dispense only a predetermined amount of cells at the predetermined depth.
Claim 10
Dependent Claim
36 words
An instrument for grafting cells into an intraretinal eye area as recited in claim 5, in which said tip comprises a 30 gauge needle tip extending at an angle to the distal end of said frame.
Claim 11
Dependent Claim
36 words
An instrument for grafting cells into an intraretinal eye area as recited in claim 5, in which said tip comprises a 27 gauge needle tip extending at an angle to the distal end of said frame.
Claim 12
Dependent Claim
47 words
An instrument for grafting cells into an intraretinal eye area as recited in claim 5, in which said tip comprises a screw thread and said adjustable collar has a mating screw thread to allow varying degrees of penetration by the degree to which said screw threads mate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-24 | 1998-10-24 | 1999-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-24 | 2002-10-24 | 2003-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-24 | 2006-10-24 | 2007-04-25 | $7700.00 | Window Closed / Lapsed |