US5407671A
Expired / Lapsed
US
⏱️ 0.0 years remaining
One-component tissue adhesive and a process for the production thereof
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1992-11-30
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Granted: 1995-04-18
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Expires: 2012-11-30
Abstract
Abstract A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof. This adhesive can be reconstituted from a freeze-dried form with water. It can contain all active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.
Inventors
- 👤 Norbert Heimburger
- 👤 Peter Fuhge
- 👤 Hansjorg Ronneberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:21
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; A61P; A61P17/00; A61P43/00
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
87 words
A one component tissue adhesive in solid form having as active substances when reconstituted in 1 ml of solution: 65-115 mg of human fibrinogen, 40-80 U of factor XIII, 1-50 IU of PPSB (prothrombin factors) based on factor II (prothrombin), 0.01-50 IU of antithrombin III, 0.1-5 mmol/l of calcium ions, and 1-10,000 KIU of aprotinin, wherein the ratio of said active substances is such that there is no premature coagulation of said adhesive during preparation, and such that coagulation is initiated on contact with a wound surface.
Claim 2
Dependent Claim
87 words
A one component tissue adhesive in solid form having as active substances when reconstituted in 1 ml of solution: 65-115 mg of human fibrinogen, 40-80 U of factor XIII, 1-50 IU of PPSB (prothrombin factors) based on factor II (prothrombin), 0.01-50 IU of antithrombin III, 0.1-5 mmol/l of calcium ions, and 1-10,000 KIU of aprotinin, wherein the ratio of said active substances is such that there is no premature coagulation of said adhesive during preparation, and such that coagulation is initiated on contact with a wound surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-17 | 1998-10-17 | 1999-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-17 | 2002-10-17 | 2003-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-17 | 2006-10-17 | 2007-04-18 | $7700.00 | Window Closed / Lapsed |