US5376380A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of producing liposomal products from freeze or spray-dried preparations of liposomes
Assignee: Daiichi Pharmaceutical Co Ltd
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Filing: 1993-06-22
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Granted: 1994-12-27
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Expires: 2013-06-22
Abstract
Abstract A method of producing liposomal products which comprises treating a positively or negatively charged, freeze- or spray-dried liposomal preparation with an aqueous solution of a drug charged oppositely to the charge of the liposomes.
Inventors
- 👤 Hiroshi Kikuchi
- 👤 Kiyoto Yachi
- 👤 Hiromi Morita
- 👤 Sadao Hirota
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:49
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
87 words
A method of producing liposomal products which comprises contacting a positively or negatively charged, freeze- or spray--dried preparation of liposomes with an aqueous solution of a drug charged oppositely to the charge of the liposomes, wherein the total concentration of ions, excluding the charged drug, in the aqueous solution of a charged drug is not more than 40mM, and wherein the ratio of the amount of charged lipid in the preparation of liposomes to the total amount of liposomal membrane components is 10 to 30 mole percent.
Claim 2
Independent Claim
87 words
A method of producing liposomal products which comprises contacting a positively or negatively charged, freeze- or spray--dried preparation of liposomes with an aqueous solution of a drug charged oppositely to the charge of the liposomes, wherein the total concentration of ions, excluding the charged drug, in the aqueous solution of a charged drug is not more than 40mM, and wherein the ratio of the amount of charged lipid in the preparation of liposomes to the total amount of liposomal membrane components is 10 to 30 mole percent.
Claim 3
Dependent Claim
38 words
A method of producing liposomal products as claimed in claim 1, wherein charged lipid in the preparation of liposomes is present in an amount of not less than 2, on an ionic equivalent basis relative to the drug.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-26 | 1998-06-27 | 1998-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-26 | 2002-06-27 | 2002-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-26 | 2006-06-27 | 2006-12-27 | $7700.00 | Window Closed / Lapsed |