US5370802A
Expired / Lapsed
US
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Enhanced yield platelet collection systems and methods
Assignee: Fenwal Inc
•
Filing: 1992-10-22
•
Granted: 1994-12-06
•
Expires: 2012-10-22
Abstract
Abstract Systems and methods for separating a suspension of plasma and platelets from whole blood rotate a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone. The systems and methods introduce whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region. This creates a strong flow of plasma that moves radially toward the low-G zone of the inlet region and elutes platelets into suspension with it. The systems and methods direct the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber. The systems and methods also drag the interface into this radial plasma flow, eluting even the largest of platelets into suspension for collection.
Inventors
- 👤 Richard I. Brown
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:06
CPC Classifications
B; B04; B04B; B04B13/00; A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/029; A61M1/14; A61M1/30; A61M1/301; A61M1/302; A61M1/303; A61M1/305; A61M1/308; A61M1/36; A61M1/3601; A61M1/3603; A61M1/3621; A61M1/3624; A61M1/3693; A61M1/3696; B01; B01D; B01D17/00; B01D17/02; B01D17/0217; B01D21/00; B01D21/0003; B01D21/24; B01D21/2405; B01D21/245; B01D21/2488; B01D21/26; B01D21/262; B01D21/30; B01D21/32; B01D21/34; B04B5/00; B04B5/04; B04B5/0442; B04B7/00; B04B7/08; A61M1/025; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0427; A61M2205/00; A61M2205/33; A61M2205/3306; A61M2205/331; A61M2205/3331; A61M2205/3344; A61M2205/3351; A61M2205/3355; A61M2205/3379; A61M2205/3393; B01D2221/00; B01D2221/10; B04B2005/045
Claims Analysis
Total Claims: 54
Claim 1
Independent Claim
135 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means for defining first and second spaced apart walls forming, when oriented for use, a separation zone having a low-G side located closer to the rotational axle than the other, high-G side, the separation zone including an entry region, means for an inlet port for Introducing whole blood into the entry region for separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side, and means defining a first outlet port in the entry region for collecting the plasma constituent from the low-G aide of the separation zone at least in part while whole blood is introduced into the entry region through the inlet port.
Claim 2
Dependent Claim
135 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means for defining first and second spaced apart walls forming, when oriented for use, a separation zone having a low-G side located closer to the rotational axle than the other, high-G side, the separation zone including an entry region, means for an inlet port for Introducing whole blood into the entry region for separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side, and means defining a first outlet port in the entry region for collecting the plasma constituent from the low-G aide of the separation zone at least in part while whole blood is introduced into the entry region through the inlet port.
Claim 3
Dependent Claim
34 words
A chamber according to claim 1 and further including means defining a second outlet port spaced away from the entry region for collecting red blood cells on the high-G side of the separation zone.
Claim 4
Dependent Claim
182 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means defining first end second spaced apart walls for forming a chamber having a first region and a second region spaced from the first region, the first wall being oriented, in use, closer to the rotational axis than the second wall, means defining an inlet in the first region for directing whole blood into the first region of the chamber for separation into a first zone of red blood cells along the second wall and a second zone of plasma constituent along the first wall, means defining a first outlet in the second region of the chamber for conveying separated red blood cells the first zone, and means defining a second outlet for conveying the plasma constituent from the second zone at least in part while whole blood is directed through the inlet into the first region, the second outlet being located closer to the first region of the chamber than to the second region of the chamber.
Claim 5
Dependent Claim
182 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means defining first end second spaced apart walls for forming a chamber having a first region and a second region spaced from the first region, the first wall being oriented, in use, closer to the rotational axis than the second wall, means defining an inlet in the first region for directing whole blood into the first region of the chamber for separation into a first zone of red blood cells along the second wall and a second zone of plasma constituent along the first wall, means defining a first outlet in the second region of the chamber for conveying separated red blood cells the first zone, and means defining a second outlet for conveying the plasma constituent from the second zone at least in part while whole blood is directed through the inlet into the first region, the second outlet being located closer to the first region of the chamber than to the second region of the chamber.
Claim 6
Dependent Claim
18 words
A chamber according to claim 3 wherein the whole blood inlet is located opposite to the first outlet.
Claim 7
Dependent Claim
40 words
A chamber according to claim 3 wherein the wall means define edges joining the first and second walls, wherein the whole blood inlet and the second outlet are located next to each other along the same edge of the chamber.
Claim 8
Dependent Claim
33 words
A chamber according to claim 5 wherein the whole blood inlet and the second outlet are located on an edge that is opposite to the edge along which the first outlet is located.
Claim 9
Independent Claim
159 words
A device for separating a suspension of plasma end platelets from whole blood comprising wall means defining a separation chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, and first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber at least in part while whole blood is introduced by the inlet means into the first chamber region.
Claim 10
Independent Claim
159 words
A device for separating a suspension of plasma end platelets from whole blood comprising wall means defining a separation chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, and first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber at least in part while whole blood is introduced by the inlet means into the first chamber region.
Claim 11
Dependent Claim
29 words
A device according to claim 7 wherein the inlet means conveys whole blood into the first chamber region in a path that extends generally parallel to the rotational axis.
Claim 12
Dependent Claim
29 words
A device according to claim 7 wherein the inlet means conveys whole blood into the first chamber region in a path that extends generally circumferentially about the rotational axis.
Claim 13
Dependent Claim
29 words
A device according to claim 7 and further including second collection means for directing red blood cells to a second port for transporting red blood cells from the chamber.
Claim 14
Dependent Claim
39 words
A device according to claim 7 and further including second collection means for directing red blood cells from the first chamber region to a second port spaced from the first port for transporting red blood cells from the chamber.
Claim 15
Dependent Claim
30 words
A device according to claim 11 wherein the second collection means conveys red blood cells to the second port in a path that extends generally parallel to the rotational axis.
Claim 16
Dependent Claim
30 words
A device according to claim 11 wherein the second collection means conveys red blood cells to the second port in a path that extends generally circumferentially about the rotational axis.
Claim 17
Dependent Claim
53 words
A device according to claim 11 wherein at least a portion of the low-G wall that extends between the first port and the second port is tapered toward the high-G wall so that the radial distance between the low-G and high-G wall is less near the second port than near the first port.
Claim 18
Dependent Claim
80 words
A device according to claim 7 and further including means for directing red blood cells in the first chamber region toward a second region in the chamber for further separation of red blood cells toward the high-G wall and plasma toward the low-G wall, and means for directing plasma separated in the second chamber region into the radial flow of plasma and eluted platelets in the first chamber region for their combined transport from the chamber through the first port.
Claim 19
Dependent Claim
72 words
A device according to claim 15 wherein the means for directing plasma separated in the second chamber region into the radial flow of plasma and eluted platelets in the first chamber region includes means for tapering at least a portion of the low-G wall toward the high-G wall so that the radial distance between the low-G and high-G wall is less in the second chamber region than in the first chamber region.
Claim 20
Dependent Claim
184 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means for defining first and second spaced apart walls forming a separation zone having, in use, a low-G side located closer to the rotational axis than the other, high-G side, the separation zone forms a blood flow path that includes an entry region where whole blood enters the separation chamber to begin separation and a terminal region spaced from the entry region where separation is halted, means for conveying whole blood through the blood flow path from the entry region toward the terminal region to successively increase the surface hematocrit along the flow path by separating red blood cells toward the high-G side and the plasma constituent toward the low-G side, and means defining e first port in the entry region for collecting, at least in part while whole blood enters the entry region, the plasma constituent from the low-G side of the separation zone in the entry region where the surface hematocrit along the flow path is the least.
Claim 21
Dependent Claim
184 words
A chamber for use in a rotating field to separate whole blood into red blood cells and a plasma constituent carrying platelets comprising wall means for defining first and second spaced apart walls forming a separation zone having, in use, a low-G side located closer to the rotational axis than the other, high-G side, the separation zone forms a blood flow path that includes an entry region where whole blood enters the separation chamber to begin separation and a terminal region spaced from the entry region where separation is halted, means for conveying whole blood through the blood flow path from the entry region toward the terminal region to successively increase the surface hematocrit along the flow path by separating red blood cells toward the high-G side and the plasma constituent toward the low-G side, and means defining e first port in the entry region for collecting, at least in part while whole blood enters the entry region, the plasma constituent from the low-G side of the separation zone in the entry region where the surface hematocrit along the flow path is the least.
Claim 22
Dependent Claim
38 words
A chamber according to claim 17 and further including means defining a second port in the terminal region for collecting red blood cells from the high-G side of the flow path where the surface hematocrit is the most.
Claim 23
Dependent Claim
19 words
A chamber according to claim 17 wherein the blood flow path extends generally parallel to the axis of rotation.
Claim 24
Dependent Claim
18 words
A chamber according to claim 17 wherein the blood flow path extends generally circumferentially about the rotational axis.
Claim 25
Dependent Claim
182 words
A blood separation system comprising a separation device including wall means defining a first chamber and a second chamber, each of the chambers being operable for rotation about an axis to create within the respective chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the first chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the first chamber, and means for conveying the plasma and eluted platelets from the first port into the second chamber for separation during its rotation into plasma toward its low-G wall and platelet concentrate toward its high-G wall.
Claim 26
Dependent Claim
182 words
A blood separation system comprising a separation device including wall means defining a first chamber and a second chamber, each of the chambers being operable for rotation about an axis to create within the respective chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the first chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the first chamber, and means for conveying the plasma and eluted platelets from the first port into the second chamber for separation during its rotation into plasma toward its low-G wall and platelet concentrate toward its high-G wall.
Claim 27
Dependent Claim
30 words
A system according to claim 21 and further including second collection means for directing red blood cells to a second port for transporting red blood cells from the first chamber.
Claim 28
Dependent Claim
44 words
A system according to claim 21 and further including second collection means for directing red blood cells from the first chamber region to a second port spaced from the first port in the first chamber for transporting red blood cells from the first chamber.
Claim 29
Dependent Claim
162 words
A blood separation system comprising a separation device including wall means defining a chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber, and means communicating with the inlet means for introducing a fluid into the whole blood to lower the surface hematocrit of the blood within the first chamber region.
Claim 30
Dependent Claim
162 words
A blood separation system comprising a separation device including wall means defining a chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber, and means communicating with the inlet means for introducing a fluid into the whole blood to lower the surface hematocrit of the blood within the first chamber region.
Claim 31
Dependent Claim
28 words
A system according to claim 24 wherein the fluid introduction means includes means for controlling the amount of fluid introduced into the whole blood according to prescribed criteria.
Claim 32
Dependent Claim
165 words
A blood separation system comprising a separation device including wall means defining a chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber, and means for recirculating a portion of the plasma and eluted platelets from the first port to the inlet means for introduction with the whole blood into the first chamber region.
Claim 33
Dependent Claim
165 words
A blood separation system comprising a separation device including wall means defining a chamber operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the chamber, and means for recirculating a portion of the plasma and eluted platelets from the first port to the inlet means for introduction with the whole blood into the first chamber region.
Claim 34
Dependent Claim
29 words
A system according to claim 26 wherein the recirculation means includes means for controlling the portion of the plasma and eluted platelets that is recirculated according to prescribed criteria.
Claim 35
Dependent Claim
216 words
A blood separation system comprising a separation device including wall means defining a first chamber and a second chamber, each of the chambers being operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the first chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the first chamber, means for conveying the plasma and eluted platelets from the first port into the second chamber for separation during its rotation into plasma and platelet concentrate, second collection means for collecting plasma from the second chamber, and means for recirculating at least a portion of the plasma from the second chamber to the inlet means of the first chamber for introduction with the whole blood into the first chamber region.
Claim 36
Dependent Claim
216 words
A blood separation system comprising a separation device including wall means defining a first chamber and a second chamber, each of the chambers being operable for rotation about an axis to create within the chamber a low-G wall radially close to the axis and a high-G wall spaced radially further from the axis than the low-G wall, inlet means for introducing whole blood into a first region of the first chamber during its rotation to initiate separation of red blood cells within the first chamber region toward the high-G wall and create a flow of plasma that moves within the first chamber region radially toward the low-G wall and elutes platelets into suspension, first collection means for directing the radial flow of plasma and eluted platelets in the first chamber region to a first port in the first chamber region for transport from the first chamber, means for conveying the plasma and eluted platelets from the first port into the second chamber for separation during its rotation into plasma and platelet concentrate, second collection means for collecting plasma from the second chamber, and means for recirculating at least a portion of the plasma from the second chamber to the inlet means of the first chamber for introduction with the whole blood into the first chamber region.
Claim 37
Dependent Claim
26 words
A system according to claim 28 wherein the recirculation means includes means for controlling the portion of the plasma that is recirculated according to prescribed criteria.
Claim 38
Independent Claim
139 words
A method for separating a suspension of plasma and platelets from whole blood comprising the steps of rotating a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone, introducing whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region, thereby creating a flow of plasma that moves radially toward the low-G zone of the inlet region end elutes platelets into suspension with it, and directing the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber at least in part while whole blood is introduced into, the inlet region.
Claim 39
Independent Claim
139 words
A method for separating a suspension of plasma and platelets from whole blood comprising the steps of rotating a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone, introducing whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region, thereby creating a flow of plasma that moves radially toward the low-G zone of the inlet region end elutes platelets into suspension with it, and directing the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber at least in part while whole blood is introduced into, the inlet region.
Claim 40
Dependent Claim
31 words
A method according to claim 30 wherein the step of introducing whole blood conveys whole blood into the inlet region in a path that extends generally parallel to the rotational axis.
Claim 41
Dependent Claim
31 words
A method according to claim 30 wherein the step of introducing whole blood conveys whole blood into the inlet region in a path that extends generally circumferentially about the rotational axis.
Claim 42
Dependent Claim
34 words
A method according to claim 30 and further including the step of conveying red blood cells to a port in a second region spaced from the inlet region for transport out of the chamber.
Claim 43
Dependent Claim
33 words
A method according to claim 33 wherein the step of conveying red blood cells conveys red blood cells from the inlet region in a path that extends generally parallel to the rotational axis.
Claim 44
Dependent Claim
35 words
A method according to claim 33 wherein the step of conveying the red blood cells conveys red blood cells away from the inlet region in a path that extends generally circumferentially about the rotational axis.
Claim 45
Dependent Claim
44 words
A method according to claim 33 and further including the step of conveying red blood cells from the inlet region toward the second region within the chamber while continuing to separate red blood cells toward the high-G zone and plasma toward the low-G zone.
Claim 46
Dependent Claim
33 words
A method according to claim 36 wherein the step of conveying red blood cells conveys red blood cells from the inlet region in a path that extends generally parallel to the rotational axis.
Claim 47
Dependent Claim
35 words
A method according to claim 36 wherein the step of conveying the red blood cells conveys red blood cells away from the inlet region in a path that extends generally circumferentially about the rotational axis.
Claim 48
Dependent Claim
33 words
A method according to claim 36 and further including the step of directing plasma separated in the second region into the radial flow of plasma and eluted platelets created in the inlet region.
Claim 49
Dependent Claim
70 words
A method according to claim 36 wherein, in separating red blood cells in the chamber, an interface region forms between the red blood cells and the plasma, and further including the step of directing plasma from the second region along the interface to move the interface region into the radial flow of plasma created in the inlet region to elute platelets from the interface region into suspension in the plasma.
Claim 50
Independent Claim
175 words
A method for separating whole blood into red blood cells and a plasma constituent carrying platelets comprising the steps of rotating a chamber about an axis to create within the chamber a low-G zone radially close to the axis end a high-G zone spaced radially further from the axis than the low-G zone, the chamber forming a blood flow path that includes an entry region where whole blood enters the chamber to begin separation and a terminal region spaced from the entry region where separation is halted, conveying whole blood through the blood flow path from the entry region toward the terminal region to successively increase the surface hematocrit along the flow path by separating red blood cells toward the high-G zone and the plasma constituent toward the low-G zone, end collecting through a port in the entry region, at least in part while Whole blood enters the entry region, the plasma constituent from the low-G zone of the flow path in the entry region where surface hematocrit along the flow path is the least.
Claim 51
Independent Claim
175 words
A method for separating whole blood into red blood cells and a plasma constituent carrying platelets comprising the steps of rotating a chamber about an axis to create within the chamber a low-G zone radially close to the axis end a high-G zone spaced radially further from the axis than the low-G zone, the chamber forming a blood flow path that includes an entry region where whole blood enters the chamber to begin separation and a terminal region spaced from the entry region where separation is halted, conveying whole blood through the blood flow path from the entry region toward the terminal region to successively increase the surface hematocrit along the flow path by separating red blood cells toward the high-G zone and the plasma constituent toward the low-G zone, end collecting through a port in the entry region, at least in part while Whole blood enters the entry region, the plasma constituent from the low-G zone of the flow path in the entry region where surface hematocrit along the flow path is the least.
Claim 52
Dependent Claim
42 words
A method according to claim 41 and further including the step of collecting red blood cells from the high-G zone of the flow path in the terminal region where the surface hematocrit is the most through a port in the terminal region.
Claim 53
Dependent Claim
19 words
A method according to claim 41 wherein the blood flow path extends generally parallel to the axis of rotation.
Claim 54
Dependent Claim
18 words
A method according to claim 41 wherein the blood flow path extends generally circumferentially about the rotational axis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-05 | 1998-06-06 | 1998-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-05 | 2002-06-06 | 2002-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-05 | 2006-06-06 | 2006-12-06 | $7700.00 | Window Closed / Lapsed |