US5368736A
Expired / Lapsed
US
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Process for the separation and purification of yttrium-90 for medical applications
Assignee: United States Department of Energy
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Filing: 1993-07-26
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Granted: 1994-11-29
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Expires: 2013-07-26
Abstract
Abstract An extraction chromatographic method for the preparation of 90Y of high chemical and radiochemical purity is disclosed. After an initial purification of a 90Sr stock solution and a suitable period of 90Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the 90Sr content of the mixture by a factor of about 103. The 90Y remaining is freed from any residual 90Sr, from its 90Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium.
Inventors
- 👤 Philip E. Horwitz
- 👤 Mark L. Dietz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:03
CPC Classifications
G; G21; G21G; G21G1/00; G21G1/001; C; C01; C01F; C01F17/00; C01F17/10; C01F17/13; C22; C22B; C22B59/00; G21G2001/0094
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
209 words
A process for the separation and purification of yttrium-90 from strontium-90 comprising: a) purifying an original 90 Sr solution by dissolving the residue remaining after evaporation of the original solution in nitric acid and passing it through a strontium-selective chromatographic column; b) stripping sorbed 90 Sr with dilute nitric acid; c) removing any traces of organic materials present in the purified 90 Sr by passing it through a bed of a polymeric sorbent; d) storing the 90 Sr solution for a sufficient period of time to allow 90 Y ingrowth to occur in the solution to provide a 90 Sr/ 90 Y mixture; e) acidifying the 90 Sr/ 90 Y mixture and passing the mixture through a series of strontium-selective extractant columns such that essentially all of the 90 Sr is retained on the columns and the effluent from the third column contains essentially only 90 Y; f) passing the 90 Y effluent through a rare-earth selective extractant such that 90 Y is retained while any residual 90 Sr is stripped away; g) eluting sorbed 90 Y from the rare-earth selective column; h) stripping each of the strontium-selective extractant columns of sorbed 90 Sr with dilute nitric acid and returning to storage to allow for new 90 Y growth.
Claim 2
Dependent Claim
209 words
A process for the separation and purification of yttrium-90 from strontium-90 comprising: a) purifying an original 90 Sr solution by dissolving the residue remaining after evaporation of the original solution in nitric acid and passing it through a strontium-selective chromatographic column; b) stripping sorbed 90 Sr with dilute nitric acid; c) removing any traces of organic materials present in the purified 90 Sr by passing it through a bed of a polymeric sorbent; d) storing the 90 Sr solution for a sufficient period of time to allow 90 Y ingrowth to occur in the solution to provide a 90 Sr/ 90 Y mixture; e) acidifying the 90 Sr/ 90 Y mixture and passing the mixture through a series of strontium-selective extractant columns such that essentially all of the 90 Sr is retained on the columns and the effluent from the third column contains essentially only 90 Y; f) passing the 90 Y effluent through a rare-earth selective extractant such that 90 Y is retained while any residual 90 Sr is stripped away; g) eluting sorbed 90 Y from the rare-earth selective column; h) stripping each of the strontium-selective extractant columns of sorbed 90 Sr with dilute nitric acid and returning to storage to allow for new 90 Y growth.
Claim 3
Dependent Claim
19 words
The process of claim 1 wherein the strontium selective extractant resin is obtained from an octanol solution of di-t-butylcyclohexano-18-crown-6.
Claim 4
Dependent Claim
19 words
The process of claim 2 wherein the yttrium-selective extractant is obtained from a solution of octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide in tributylphosphate.
Claim 5
Dependent Claim
159 words
A process for the separation and purification of curie quantities of yttrium-90 from strontium-90 comprising: a) contacting an original feed stock strontium-90 solution with a strontium-selective extraction chromatographic resin whereby purified strontium is retained, and any yttrium and zirconium present in the solution are flushed away; b) removing any traces of organic materials from the purified strontium solution and storing this solution for a sufficient period of time to allow yttrium-90 ingrowth to occur so that a strontium-90/yttrium-90 mixture is obtained; c) acidifying the strontium-90/yttrium-90 mixture and selectively separating the strontium-90 from the yttrium-90 by contacting the mixture with a series of strontium- selective extraction columns such that strontium is retained on the columns and that the effluent from the last column contains only yttrium-90; d) contacting the yttrium-90 containing effluent with a rare-earth selective extraction column such that yttrium-90 is retained and any residual strontium-90 is not retained; e) eluting the sorbed yttrium-90 from the rare-earth selective column.
Claim 6
Dependent Claim
159 words
A process for the separation and purification of curie quantities of yttrium-90 from strontium-90 comprising: a) contacting an original feed stock strontium-90 solution with a strontium-selective extraction chromatographic resin whereby purified strontium is retained, and any yttrium and zirconium present in the solution are flushed away; b) removing any traces of organic materials from the purified strontium solution and storing this solution for a sufficient period of time to allow yttrium-90 ingrowth to occur so that a strontium-90/yttrium-90 mixture is obtained; c) acidifying the strontium-90/yttrium-90 mixture and selectively separating the strontium-90 from the yttrium-90 by contacting the mixture with a series of strontium- selective extraction columns such that strontium is retained on the columns and that the effluent from the last column contains only yttrium-90; d) contacting the yttrium-90 containing effluent with a rare-earth selective extraction column such that yttrium-90 is retained and any residual strontium-90 is not retained; e) eluting the sorbed yttrium-90 from the rare-earth selective column.
Claim 7
Dependent Claim
17 words
The process of claim 1 wherein the strontium-90 feed stock contains up to 3 molar nitric acid.
Claim 8
Dependent Claim
16 words
The process of claim 5 wherein the strontium-selective extraction resin includes an octanol solution of di-t-butylcyclohexano-18-crown-6.
Claim 9
Dependent Claim
16 words
The process of claim 6 wherein the rare-earth selective extraction resin includes octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide in tributylphosphate.
Claim 10
Dependent Claim
30 words
The process of claim 7 including the step of stripping sorbed strontium-90 from the strontium-selective columns with a dilute acid and returning to storage to allow for new yttrium-90 ingrowth.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-28 | 1998-05-30 | 1998-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-28 | 2002-05-30 | 2002-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-28 | 2006-05-30 | 2006-11-29 | $7700.00 | Window Closed / Lapsed |